acalabrutinib | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

Home
Ligands
acalabrutinib
Ligand Activity Charts

acalabrutinib [Ligand Id: 8912] activity data from GtoPdb

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
erb-b2 receptor tyrosine kinase 4 in Human [GtoPdb: 1799] [UniProtKB: Q15303] There should be some charts here, you may need to enable JavaScript!
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451] There should be some charts here, you may need to enable JavaScript!
BMX non-receptor tyrosine kinase in Human [GtoPdb: 1942] [UniProtKB: P51813] There should be some charts here, you may need to enable JavaScript!
Bruton tyrosine kinase in Human [GtoPdb: 1948] [UniProtKB: Q06187] There should be some charts here, you may need to enable JavaScript!
erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
IL2 inducible T cell kinase in Human [GtoPdb: 2046] [UniProtKB: Q08881] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
tec protein tyrosine kinase in Human [GtoPdb: 2238] [UniProtKB: P42680] There should be some charts here, you may need to enable JavaScript!
TXK tyrosine kinase in Human [GtoPdb: 2268] [UniProtKB: P42681] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
erb-b2 receptor tyrosine kinase 4 in Human [GtoPdb: 1799] [UniProtKB: Q15303]
GtoPdb	-	-	7.8	pIC50	16	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
BMX non-receptor tyrosine kinase in Human [GtoPdb: 1942] [UniProtKB: P51813]
GtoPdb	-	-	7.34	pIC50	46	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
Bruton tyrosine kinase in Human [GtoPdb: 1948] [UniProtKB: Q06187]
GtoPdb	-	-	8.29	pIC50	5.1	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
GtoPdb	-	-	8	pEC50	<10	nM	EC50	US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
erb-b2 receptor tyrosine kinase 2 in Human [GtoPdb: 2019] [UniProtKB: P04626]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
FYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2026] [UniProtKB: P06241]
GtoPdb	-	-	6	pEC50	>1000	nM	EC50	US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
IL2 inducible T cell kinase in Human [GtoPdb: 2046] [UniProtKB: Q08881]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239]
GtoPdb	-	-	6	pEC50	>1000	nM	EC50	US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
LYN proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2060] [UniProtKB: P07948]
GtoPdb	-	-	6	pIC50	>1000	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
GtoPdb	-	-	6	pEC50	1000	nM	EC50	US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb	-	-	6	pEC50	>1000	nM	EC50	US20140155385 A1. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk inhibitors. (2014)
tec protein tyrosine kinase in Human [GtoPdb: 2238] [UniProtKB: P42680]
GtoPdb	-	-	7.03	pIC50	93	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]
TXK tyrosine kinase in Human [GtoPdb: 2268] [UniProtKB: P42681]
GtoPdb	-	-	6.43	pIC50	368	nM	IC50	N Engl J Med (2016) 374: 323-32 [PMID:26641137]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.