ChEMBL ligand: CHEMBL567470
phosphodiesterase 4A/3`,5`-cyclic-AMP phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/3`,5`-cyclic-AMP phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/3`,5`-cyclic-AMP phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/3`,5`-cyclic-AMP phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 7B/3`,5`-cyclic-AMP phosphodiesterase 7B in Human [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 2A/cGMP-dependent 3`,5`-cyclic phosphodiesterase in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3A/cGMP-inhibited 3`,5`-cyclic phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3B/cGMP-inhibited 3`,5`-cyclic phosphodiesterase 3B in Human [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/cGMP-specific 3`,5`-cyclic phosphodiesterase in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 11A/Dual 3`,5`-cyclic-AMP and -GMP phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1A/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1A in Human [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1B in Human [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1C/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1C in Human [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 7A/High affinity 3`,5`-cyclic-AMP phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 8A/High affinity cAMP-specific and IBMX-insensitive 3`,5`-cyclic phosphodiesterase 8A in Human [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 8B/High affinity cAMP-specific and IBMX-insensitive 3`,5`-cyclic phosphodiesterase 8B in Human [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 9A/High affinity cGMP-specific 3`,5`-cyclic phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 6A/Rod cGMP-specific 3`,5`-cyclic phosphodiesterase subunit alpha in Human [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4A/3`,5`-cyclic-AMP phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL	Inhibition of PDE4A	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4B/3`,5`-cyclic-AMP phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of PDE4B	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
ChEMBL	Inhibition of PDE4B	B	6.54	pIC50	290	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4C/3`,5`-cyclic-AMP phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
ChEMBL	Inhibition of PDE4C	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 4D/3`,5`-cyclic-AMP phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of PDE4D	B	5.92	pIC50	1210	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 7B/3`,5`-cyclic-AMP phosphodiesterase 7B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4716] [GtoPdb: 1306] [UniProtKB: Q9NP56]
ChEMBL	Inhibition of PDE7B	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 2A/cGMP-dependent 3`,5`-cyclic phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL	Inhibition of PDE2	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 3A/cGMP-inhibited 3`,5`-cyclic phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL	Inhibition of PDE3A	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 3B/cGMP-inhibited 3`,5`-cyclic phosphodiesterase 3B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370]
ChEMBL	Inhibition of PDE3B	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 5A/cGMP-specific 3`,5`-cyclic phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
GtoPdb	-	-	10.3	pIC50	0.05	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533]
ChEMBL	Inhibition of PDE5	B	10.3	pIC50	0.05	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 11A/Dual 3`,5`-cyclic-AMP and -GMP phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL	Inhibition of PDE11	B	7.19	pIC50	64.1	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1A/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421] [GtoPdb: 1294] [UniProtKB: P54750]
ChEMBL	Inhibition of PDE1A	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
ChEMBL	Inhibition of PDE1B	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 1C/Dual specificity calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4619] [GtoPdb: 1296] [UniProtKB: Q14123]
ChEMBL	Inhibition of PDE1C	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 7A/High affinity 3`,5`-cyclic-AMP phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
ChEMBL	Inhibition of PDE7A	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 8A/High affinity cAMP-specific and IBMX-insensitive 3`,5`-cyclic phosphodiesterase 8A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4640] [GtoPdb: 1307] [UniProtKB: O60658]
ChEMBL	Inhibition of PDE8A	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 8B/High affinity cAMP-specific and IBMX-insensitive 3`,5`-cyclic phosphodiesterase 8B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4408] [GtoPdb: 1308] [UniProtKB: O95263]
ChEMBL	Inhibition of PDE8B	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 9A/High affinity cGMP-specific 3`,5`-cyclic phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
ChEMBL	Inhibition of PDE9	B	5.7	pIC50	>2000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
phosphodiesterase 6A/Rod cGMP-specific 3`,5`-cyclic phosphodiesterase subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3878] [GtoPdb: 1312] [UniProtKB: P16499]
ChEMBL	Inhibition of PDE6	B	8.01	pIC50	9.8	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-5213 [PMID:19631533]
GtoPdb	-	-	8.01	pIC50	9.8	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5209-13 [PMID:19631533]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]