Rec 15/2615 [Ligand Id: 8459] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL430717 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | The binding affinity towards Alpha-1C adrenergic receptor in the COS cell line. | B | 7.99 | pKi | 10.34 | nM | Ki | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130] | ||||||||
| ChEMBL | Binding affinity was tested on cloned bovine Alpha-1A adrenergic receptor | B | 7.76 | pIC50 | 17.2 | nM | IC50 | J Med Chem (1997) 40: 1293-1315 [PMID:9135028] |
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
| ChEMBL | The binding affinity towards Alpha-1A adrenergic receptor in the COS cell line. | B | 8.12 | pKi | 7.5 | nM | Ki | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| ChEMBL | The binding affinity towards Alpha-1B adrenergic receptor in the COS cell line. | B | 9.35 | pKi | 0.45 | nM | Ki | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| GtoPdb | - | - | 9.5 | pKi | - | - | - |
J Pharmacol Exp Ther (1997) 281: 1284-93 [PMID:9190864]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144] |
| ChEMBL | Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptor | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1997) 40: 1293-1315 [PMID:9135028] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] | ||||||||
| ChEMBL | Binding affinity was tested on cloned rat Alpha-1D adrenergic receptor | B | 7.64 | pIC50 | 22.9 | nM | IC50 | J Med Chem (1997) 40: 1293-1315 [PMID:9135028] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Inhibitory concentration against Dopamine receptor D2 (Inactive at >1000 nM concentration) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Inhibitory concentration against 5-hydroxytryptamine 1A receptor (Inactive at >1000 nM concentration) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Inhibitory concentration against 5-hydroxytryptamine 2A receptor (Inactive at >1000 nM concentration) | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1999) 42: 427-437 [PMID:9986714] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
