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ChEMBL ligand: CHEMBL1802358 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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phosphoinositide kinase, FYVE-type zinc finger containing/1-phosphatidylinositol 3-phosphate 5-kinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176842] [GtoPdb: 2857] [UniProtKB: Q9Z1T6] | ||||||||
ChEMBL | Binding affinity to phosphatidylinositol-3-phosphate 5-kinase type 3 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 5.22 | pKd | 6010 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibition of human recombinant CK2 using RRREDEESDDEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3537] [GtoPdb: 1549] [UniProtKB: Q60737] | ||||||||
ChEMBL | Binding affinity to CSNK2A1 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 6.49 | pKd | 326 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5326] [GtoPdb: 1550] [UniProtKB: O54833] | ||||||||
ChEMBL | Binding affinity to CSNK2A2 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 6.24 | pKd | 574 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4095] [GtoPdb: 1551] [UniProtKB: P67871] | ||||||||
ChEMBL | Binding affinity to CSNK2N in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 6.42 | pKd | 382 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
cyclin dependent kinase 2/CDK2/Cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941] | ||||||||
ChEMBL | Inhibition of human recombinant CDK2/cyclin A using [gamma-33P]-ATP after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
ChEMBL | Inhibition of human recombinant CDK9/cyclin T expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant CDK9/cyclin T using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
ChEMBL | Inhibition of CDK2/cyclin A using [gamma33P]ATP after 30 mins by scintillation counting | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
ChEMBL | Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant CDK5/p25 using [gamma-33P]-ATP after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
ChEMBL | Inhibition of human recombinant CDK5/p25 | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2011) 54: 4172-4186 [PMID:21615147] |
cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613, P51946] | ||||||||
ChEMBL | Inhibition of human recombinant CDK7/cyclin H expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518] | ||||||||
ChEMBL | Inhibition of mouse recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 7.15 | pIC50 | 71 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.46 | pIC50 | 35 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
ChEMBL | Inhibition of mouse recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2011) 54: 4172-4186 [PMID:21615147] |
GtoPdb | - | - | 10.82 | pIC50 | 0.01 | nM | IC50 | J Med Chem (2011) 54: 4172-86 [PMID:21615147] |
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
ChEMBL | Binding affinity to CLK2 | B | 6.44 | pKd | 360 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491] | ||||||||
ChEMBL | Inhibition of mouse recombinant GST-tagged CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 6.14 | pIC50 | 720 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 6.49 | pIC50 | 320 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
ChEMBL | Binding affinity to CLK3 | B | 5.96 | pKd | 1100 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492] | ||||||||
ChEMBL | Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 4172-4186 [PMID:21615147] |
ChEMBL | Inhibition of mouse recombinant GST-tagged CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
GtoPdb | - | - | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2011) 54: 4172-86 [PMID:21615147] |
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
ChEMBL | Binding affinity to CLK4 | B | 7.15 | pKd | 70 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493] | ||||||||
ChEMBL | Inhibition of mouse recombinant GST-tagged CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 7.19 | pIC50 | 64 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.51 | pIC50 | 31 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470] | ||||||||
ChEMBL | Inhibition of rat recombinant GST-tagged DYRK1A using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2011) 54: 4172-4186 [PMID:21615147] |
ChEMBL | Inhibition of rat recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of rat DYRK1A isolated from brain using KKISGRLSPIMTEQ as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
GtoPdb | - | - | 10.4 | pIC50 | 0.04 | nM | IC50 | J Med Chem (2011) 54: 4172-86 [PMID:21615147] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
ChEMBL | Binding affinity to DYRK1A | B | 8.11 | pKd | 7.8 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant full length GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of DYRK1A (unknown origin) | B | 7.26 | pIC50 | 55 | nM | IC50 | J Med Chem (2017) 60: 2052-2070 [PMID:28206758] |
ChEMBL | Inhibition of human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.68 | pIC50 | 21 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
ChEMBL | Inhibition of human DYRK1A using [33P]-ATP incubated for 120 mins | B | 8.12 | pIC50 | 7.6 | nM | IC50 | J Med Chem (2016) 59: 10315-10321 [PMID:27766861] |
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4750] [GtoPdb: 2009] [UniProtKB: Q61214] | ||||||||
ChEMBL | Binding affinity to DYRK1A in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 7.19 | pKd | 65 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
dual specificity tyrosine phosphorylation regulated kinase 1A in Rat [GtoPdb: 2009] [UniProtKB: Q63470] | ||||||||
GtoPdb | - | - | 10.4 | pIC50 | 0.04 | nM | IC50 | J Med Chem (2011) 54: 4172-86 [PMID:21615147] |
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
ChEMBL | Binding affinity to DYRK1B | B | 6.85 | pKd | 140 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 7.11 | pIC50 | 77 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
ChEMBL | Inhibition of human recombinant GST-tagged DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human DYRK1B using [33P]-ATP incubated for 120 mins | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2016) 59: 10315-10321 [PMID:27766861] |
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
ChEMBL | Binding affinity to DYRK2 | B | 6.35 | pKd | 450 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 6.66 | pIC50 | 220 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
ChEMBL | Inhibition of human recombinant GST-tagged DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant GST-tagged DYRK2 using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2011) 54: 4172-4186 [PMID:21615147] |
GtoPdb | - | - | 9.46 | pIC50 | 0.35 | nM | IC50 | J Med Chem (2011) 54: 4172-86 [PMID:21615147] |
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] | ||||||||
ChEMBL | Inhibition of human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate | B | 6.15 | pIC50 | 700 | nM | IC50 | Eur J Med Chem (2013) 62: 728-737 [PMID:23454515] |
ChEMBL | Inhibition of human recombinant GST-tagged DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
dual specificity tyrosine phosphorylation regulated kinase 4/Dual specificity tyrosine-phosphorylation-regulated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075115] [GtoPdb: 2013] [UniProtKB: Q9NR20] | ||||||||
GtoPdb | - | - | 6.28 | pIC50 | 520 | nM | IC50 | J Med Chem (2012) 55: 9312-30 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant GST-tagged DYRK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 6.28 | pIC50 | 520 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
ChEMBL | Binding affinity to CLK1 | B | 7.12 | pKd | 75 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of CLK1 (unknown origin) | B | 7.15 | pIC50 | 71 | nM | IC50 | J Med Chem (2017) 60: 2052-2070 [PMID:28206758] |
CDC like kinase 1 in Mouse [GtoPdb: 1990] [UniProtKB: P22518] | ||||||||
GtoPdb | - | - | 10.82 | pIC50 | 0.01 | nM | IC50 | J Med Chem (2011) 54: 4172-86 [PMID:21615147] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Binding affinity to GSK3A | B | 6.26 | pKd | 550 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL | Inhibition of human recombinant GSK3alpha expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176843] [GtoPdb: 2029] [UniProtKB: Q2NL51] | ||||||||
ChEMBL | Binding affinity to GSK3A in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 5.48 | pKd | 3274 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of human recombinant GSK3beta expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 6.42 | pIC50 | 380 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02] | ||||||||
ChEMBL | Binding affinity to HIPK1 | B | 6.49 | pKd | 320 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422] | ||||||||
ChEMBL | Binding affinity to HIPK3 | B | 6.64 | pKd | 230 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] | ||||||||
ChEMBL | Binding affinity to IRAK1 | B | 6.03 | pKd | 930 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5233] [GtoPdb: 1495] [UniProtKB: P63086] | ||||||||
ChEMBL | Inhibition of rat recombinant ERK2 using Ets1 as substrate and [gamma33P]ATP as substrate after 30 mins by scintillation counting | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
Protein VAC14 homolog in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176841] [UniProtKB: Q80WQ2] | ||||||||
ChEMBL | Binding affinity to VAC14 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 4.82 | pKd | 15265 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of human recombinant Pim1 | B | 5.39 | pIC50 | 4100 | nM | IC50 | J Med Chem (2011) 54: 4172-4186 [PMID:21615147] |
ChEMBL | Inhibition of human recombinant PIM1 expressed in Escherichia coli using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting | B | 6.06 | pIC50 | 880 | nM | IC50 | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
GtoPdb | - | - | 8.39 | pIC50 | 4.1 | nM | IC50 | J Med Chem (2011) 54: 4172-86 [PMID:21615147] |
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
ChEMBL | Binding affinity to TAOK1 | B | 5.77 | pKd | 1700 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
STE20 like kinase/STE20-like serine/threonine-protein kinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176844] [GtoPdb: 2200] [UniProtKB: O54988] | ||||||||
ChEMBL | Binding affinity to SLK1 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis | B | 7.68 | pKd | 21 | nM | Kd | J Med Chem (2012) 55: 9312-9330 [PMID:22998443] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]