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ChEMBL ligand: CHEMBL3093151 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of ALK (unknown origin) | B | 6.47 | pIC50 | 340 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6711-6716 [PMID:24210504] |
beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098] | ||||||||
ChEMBL | Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | B | 6.34 | pIC50 | 460 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6711-6716 [PMID:24210504] |
GtoPdb | - | - | 6.34 | pIC50 | 460 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6711-6 [PMID:24210504] |
G protein-coupled receptor kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5678] [GtoPdb: 1469] [UniProtKB: P34947] | ||||||||
ChEMBL | Inhibition of GRK-5 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRET assay | B | 7.23 | pIC50 | 59 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6711-6716 [PMID:24210504] |
GtoPdb | - | - | 7.23 | pIC50 | 59 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6711-6 [PMID:24210504] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of c-Met (unknown origin) | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6711-6716 [PMID:24210504] |
GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6711-6 [PMID:24210504] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]