compound 1d [PMID: 21493067] | Ligand Activity Charts

Home
Ligands
compound 1d [PMID: 21493067]
Ligand Activity Charts

compound 1d [PMID: 21493067] [Ligand Id: 8123] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1774056
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] There should be some charts here, you may need to enable JavaScript!
EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] There should be some charts here, you may need to enable JavaScript!
Insulin receptor in Human [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] There should be some charts here, you may need to enable JavaScript!
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] There should be some charts here, you may need to enable JavaScript!
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] There should be some charts here, you may need to enable JavaScript!
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] There should be some charts here, you may need to enable JavaScript!
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941]
ChEMBL	Inhibition of human CDK2/cyclinE	B	6.76	pIC50	174	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL	Inhibition of human EphB2	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of human EGFR	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL	Inhibition of human FGFR3	B	6.94	pIC50	115	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
GtoPdb	-	-	6.94	pIC50	115	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL	Inhibition of human InsR	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
ChEMBL	Inhibition of human MuSk	B	6.65	pIC50	224	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
GtoPdb	-	-	6.65	pIC50	224	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
GtoPdb	-	-	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067]
ChEMBL	Inhibition of human TRKA	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
ChEMBL	Inhibition of human Pyk2	B	6.89	pIC50	129	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL	Inhibition of JAK2 after 60 min	B	8.52	pIC50	<3	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
GtoPdb	-	-	9	pIC50	<1	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067]
ChEMBL	Inhibition of human JAK2	B	9	pIC50	<1	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb	-	-	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067]
ChEMBL	Inhibition of human JAK3	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
ChEMBL	Inhibition of JAK3 after 60 min	B	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL	Inhibition of human Lck	B	6.67	pIC50	215	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL	Inhibition of human FLT3 D835Y mutant	B	7.09	pIC50	82	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
GtoPdb	-	-	7.72	pIC50	19	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-61 [PMID:21493067]
ChEMBL	Inhibition of human RET	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2958-2961 [PMID:21493067]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]