ChEMBL ligand: CHEMBL2037226
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Mouse [ChEMBL: CHEMBL5771] [GtoPdb: 1839] [UniProtKB: P97793] There should be some charts here, you may need to enable JavaScript!
BMX non-receptor tyrosine kinase/Cytoplasmic tyrosine-protein kinase BMX in Mouse [ChEMBL: CHEMBL2034793] [GtoPdb: 1942] [UniProtKB: P97504] There should be some charts here, you may need to enable JavaScript!
EPH receptor A3/Ephrin type-A receptor 3 in Mouse [ChEMBL: CHEMBL2034794] [GtoPdb: 1823] [UniProtKB: P29319] There should be some charts here, you may need to enable JavaScript!
EPH receptor B2/Ephrin type-B receptor 2 in Mouse [ChEMBL: CHEMBL5961] [GtoPdb: 1831] [UniProtKB: P54763] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Mouse [ChEMBL: CHEMBL4066] [GtoPdb: 1810] [UniProtKB: Q61851] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Mouse [ChEMBL: CHEMBL3839] [GtoPdb: 1811] [UniProtKB: Q03142] There should be some charts here, you may need to enable JavaScript!
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Mouse [ChEMBL: CHEMBL5585] [GtoPdb: 1815] [UniProtKB: P16056] There should be some charts here, you may need to enable JavaScript!
Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Mouse [ChEMBL: CHEMBL5381] [GtoPdb: 1801] [UniProtKB: Q60751] There should be some charts here, you may need to enable JavaScript!
Insulin receptor in Mouse [ChEMBL: CHEMBL3187] [GtoPdb: 1800] [UniProtKB: P15208] There should be some charts here, you may need to enable JavaScript!
colony stimulating factor 1 receptor/Macrophage colony-stimulating factor 1 receptor in Mouse [ChEMBL: CHEMBL5570] [GtoPdb: 1806] [UniProtKB: P09581] There should be some charts here, you may need to enable JavaScript!
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Mouse [ChEMBL: CHEMBL1795170] [GtoPdb: 1816] [UniProtKB: Q62190] There should be some charts here, you may need to enable JavaScript!
KIT proto-oncogene, receptor tyrosine kinase/Mast/stem cell growth factor receptor Kit in Mouse [ChEMBL: CHEMBL2034798] [GtoPdb: 1805] [UniProtKB: P05532] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 9/Mitogen-activated protein kinase 9 in Mouse [ChEMBL: CHEMBL2034797] [GtoPdb: 1497] [UniProtKB: Q9WTU6] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Mouse [ChEMBL: CHEMBL2749] [GtoPdb: 1804] [UniProtKB: P05622] There should be some charts here, you may need to enable JavaScript!
ret proto-oncogene/Proto-oncogene tyrosine-protein kinase receptor Ret in Mouse [ChEMBL: CHEMBL2034799] [GtoPdb: 2185] [UniProtKB: P35546] There should be some charts here, you may need to enable JavaScript!
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Mouse [ChEMBL: CHEMBL2034802] [GtoPdb: 1840] [UniProtKB: Q78DX7] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Mouse [ChEMBL: CHEMBL2034796] [GtoPdb: 1807] [UniProtKB: Q00342] There should be some charts here, you may need to enable JavaScript!
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] There should be some charts here, you may need to enable JavaScript!
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fgr in Mouse [ChEMBL: CHEMBL2034795] [GtoPdb: 2024] [UniProtKB: P14234] There should be some charts here, you may need to enable JavaScript!
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Mouse [ChEMBL: CHEMBL2258] [GtoPdb: 2060] [UniProtKB: P25911] There should be some charts here, you may need to enable JavaScript!
tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Mouse [ChEMBL: CHEMBL2034800] [GtoPdb: 1841] [UniProtKB: Q06806] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Mouse [ChEMBL: CHEMBL3074] [GtoPdb: 2206] [UniProtKB: P05480] There should be some charts here, you may need to enable JavaScript!
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Mouse [ChEMBL: CHEMBL2034801] [GtoPdb: 2285] [UniProtKB: P43404] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Mouse [ChEMBL: CHEMBL3516] [GtoPdb: 1812] [UniProtKB: P35969] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5771] [GtoPdb: 1839] [UniProtKB: P97793]
ChEMBL	Inhibition of Tel-fused ALK in mouse BA/F3 cells	B	5.47	pIC50	3400	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
BMX non-receptor tyrosine kinase/Cytoplasmic tyrosine-protein kinase BMX in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034793] [GtoPdb: 1942] [UniProtKB: P97504]
ChEMBL	Inhibition of Tel-fused BMX in mouse BA/F3 cells	B	5.17	pIC50	6700	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
EPH receptor A3/Ephrin type-A receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034794] [GtoPdb: 1823] [UniProtKB: P29319]
ChEMBL	Inhibition of Tel-fused EPHA3 in mouse BA/F3 cells	B	5.23	pIC50	5900	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
EPH receptor B2/Ephrin type-B receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5961] [GtoPdb: 1831] [UniProtKB: P54763]
ChEMBL	Inhibition of Tel-fused EPHB2 in mouse BA/F3 cells	B	5.24	pIC50	5800	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4066] [GtoPdb: 1810] [UniProtKB: Q61851]
ChEMBL	Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells	B	5.03	pIC50	9300	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3839] [GtoPdb: 1811] [UniProtKB: Q03142]
ChEMBL	Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells	B	5.15	pIC50	7000	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5585] [GtoPdb: 1815] [UniProtKB: P16056]
ChEMBL	Inhibition of Tel-fused MET in mouse BA/F3 cells	B	5.24	pIC50	5800	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5381] [GtoPdb: 1801] [UniProtKB: Q60751]
ChEMBL	Inhibition of Tel-fused IGF1R in mouse BA/F3 cells	B	5.12	pIC50	7600	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
Insulin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3187] [GtoPdb: 1800] [UniProtKB: P15208]
ChEMBL	Inhibition of Tel-fused INSR in mouse BA/F3 cells	B	5.1	pIC50	8000	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
colony stimulating factor 1 receptor/Macrophage colony-stimulating factor 1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5570] [GtoPdb: 1806] [UniProtKB: P09581]
ChEMBL	Inhibition of Tel-fused FMS in mouse BA/F3 cells	B	5.4	pIC50	4000	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795170] [GtoPdb: 1816] [UniProtKB: Q62190]
ChEMBL	Inhibition of Tel-fused RON in mouse BA/F3 cells	B	5.33	pIC50	4700	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
KIT proto-oncogene, receptor tyrosine kinase/Mast/stem cell growth factor receptor Kit in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034798] [GtoPdb: 1805] [UniProtKB: P05532]
ChEMBL	Inhibition of Tel-fused KIT in mouse BA/F3 cells	B	6.04	pIC50	910	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
mitogen-activated protein kinase 9/Mitogen-activated protein kinase 9 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034797] [GtoPdb: 1497] [UniProtKB: Q9WTU6]
ChEMBL	Inhibition of Tel-fused JNK2 in mouse BA/F3 cells	B	5.54	pIC50	2900	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
GtoPdb	-	-	7.96	pIC50	11	nM	IC50	ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443]
ChEMBL	Inhibition of TRKA by HTRF assay	B	8.1	pIC50	8	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL	Inhibition of TRKB by HTRF assay	B	7.92	pIC50	12	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
GtoPdb	-	-	8.05	pIC50	9	nM	IC50	ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2749] [GtoPdb: 1804] [UniProtKB: P05622]
ChEMBL	Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells	B	6.06	pIC50	870	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
ret proto-oncogene/Proto-oncogene tyrosine-protein kinase receptor Ret in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034799] [GtoPdb: 2185] [UniProtKB: P35546]
ChEMBL	Inhibition of Tel-fused RET in mouse BA/F3 cells	B	5.28	pIC50	5300	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034802] [GtoPdb: 1840] [UniProtKB: Q78DX7]
ChEMBL	Inhibition of Tel-fused ROS in mouse BA/F3 cells	B	5.22	pIC50	6000	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034796] [GtoPdb: 1807] [UniProtKB: Q00342]
ChEMBL	Inhibition of Tel-fused FLT3 in mouse BA/F3 cells	B	5.29	pIC50	5100	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
ChEMBL	Inhibition of c-Kit in human Mo7e cells	B	6	pIC50	1000	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fgr in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034795] [GtoPdb: 2024] [UniProtKB: P14234]
ChEMBL	Inhibition of Tel-fused FGR in mouse BA/F3 cells	B	5.44	pIC50	3600	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2258] [GtoPdb: 2060] [UniProtKB: P25911]
ChEMBL	Inhibition of Tel-fused LYN in mouse BA/F3 cells	B	5.14	pIC50	7300	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034800] [GtoPdb: 1841] [UniProtKB: Q06806]
ChEMBL	Inhibition of Tel-fused TIE1 in mouse BA/F3 cells	B	5.24	pIC50	5700	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3074] [GtoPdb: 2206] [UniProtKB: P05480]
ChEMBL	Inhibition of Tel-fused SRC in mouse BA/F3 cells	B	5.14	pIC50	7300	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034801] [GtoPdb: 2285] [UniProtKB: P43404]
ChEMBL	Inhibition of Tel-fused ZAP70 in mouse BA/F3 cells	B	5.33	pIC50	4700	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3516] [GtoPdb: 1812] [UniProtKB: P35969]
ChEMBL	Inhibition of Tel-fused FLT1 in mouse BA/F3 cells	B	5.36	pIC50	4400	nM	IC50	ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443]
neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288]
GtoPdb	-	-	8.15	pIC50	7	nM	IC50	ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]