doxorubicin [Ligand Id: 7069] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL53463 (Adriablastin, Adriamycin, Doxil, Doxorubicin, Doxorubicina, Doxorubicine, Epirubicin hydrochloride impurity, doxorubicin-, Hydroxydaunorubicin, NSC-123127, NSC-759155, Rubex, Valrubicin impurity, doxorubicin)
Created with Highcharts 10.3.3ValuesChart context menuAnti-estrogen binding site (AEBS)pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
Created with Highcharts 10.3.3ValuesChart context menuArachidonate 15-lipoxygenasepKd RabbitpKi RabbitpIC50 RabbitpEC50 Rabbit0123456Highcharts.com
  • carnitine palmitoyltransferase 2/Carnitine palmitoyltransferase 2 in Rat [ChEMBL: CHEMBL4037] [GtoPdb: 3252] [UniProtKB: P18886]
Created with Highcharts 10.3.3ValuesChart context menuCarnitine palmitoyltransferase 2pKd RatpKi RatpIC50 RatpEC50 Rat012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCaspase-1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • CDGSH iron-sulfur domain-containing protein 1 in Human [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
Created with Highcharts 10.3.3ValuesChart context menuCDGSH iron-sulfur domain-containing protein 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • DNA (cytosine-5-)-methyltransferase 3α/DNA (cytosine-5)-methyltransferase 3A in Mouse [ChEMBL: CHEMBL3108652] [GtoPdb: 2750] [UniProtKB: O88508]
Created with Highcharts 10.3.3ValuesChart context menuDNA (cytosine-5)-methyltransferase 3ApKd MousepKi MousepIC50 MousepEC50 Mouse0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuDNA topoisomerase IpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuDNA topoisomerase II alphapKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuDNA topoisomerase II betapKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
Created with Highcharts 10.3.3ValuesChart context menuHuman immunodeficiency virus type 1 integrasepKd Human immunodeficiency virus 1pKi Human immunodeficiency virus 1pIC50 Human immunodeficiency virus 1pEC50 Human immunodeficiency virus 101234567Highcharts.com
  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
Created with Highcharts 10.3.3ValuesChart context menuHuman immunodeficiency virus type 1 reverse transcriptasepKd Human immunodeficiency virus 1pKi Human immunodeficiency virus 1pIC50 Human immunodeficiency virus 1pEC50 Human immunodeficiency virus 1012345Highcharts.com
  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
Created with Highcharts 10.3.3ValuesChart context menuMatrix metalloproteinase-2pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
Created with Highcharts 10.3.3ValuesChart context menuMultidrug resistance-associated protein 1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
Created with Highcharts 10.3.3ValuesChart context menuMuscarinic acetylcholine receptor M1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuP-glycoprotein 1pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium bergheipKd Plasmodium bergheipKi Plasmodium bergheipIC50 Plasmodium bergheipEC50 Plasmodium berghei01234567Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparumpKd Plasmodium falciparumpKi Plasmodium falciparumpIC50 Plasmodium falciparumpEC50 Plasmodium falciparum02468Highcharts.com
  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
Created with Highcharts 10.3.3ValuesChart context menuPurinergic receptor P2Y12pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
Created with Highcharts 10.3.3ValuesChart context menuReceptor protein-tyrosine kinase erbB-2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuRibonuclease pancreaticpKd BovinepKi BovinepIC50 BovinepEC50 Bovine012345Highcharts.com
  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Aurora-ApKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 1b (5-HT1b) receptorpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
Created with Highcharts 10.3.3ValuesChart context menuSerotonin 4 (5-HT4) receptorpKd Guinea pigpKi Guinea pigpIC50 Guinea pigpEC50 Guinea pig0123456Highcharts.com
  • SOS Ras/Rac guanine nucleotide exchange factor 1/Son of sevenless homolog 1 in Human [ChEMBL: CHEMBL2079846] [GtoPdb: 3096] [UniProtKB: Q07889]
Created with Highcharts 10.3.3ValuesChart context menuSon of sevenless homolog 1pKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
Created with Highcharts 10.3.3ValuesChart context menuTelomerase reverse transcriptasepKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • Type-2 restriction enzyme HindIII in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [ChEMBL: CHEMBL5004] [UniProtKB: P43870]
Created with Highcharts 10.3.3ValuesChart context menuType-2 restriction enzyme HindIIIpKd Haemophilus influenzae (strain ATCC 51907 /​DSM 11121 / KW20 / Rd)pKi Haemophilus influenzae (strain ATCC 51907 /​DSM 11121 / KW20 / Rd)pIC50 Haemophilus influenzae (strain ATCC 51907 /​DSM 11121 / KW20 / Rd)pEC50 Haemophilus influenzae (strain ATCC 51907 /​DSM 11121 / KW20 / Rd)012345Highcharts.com
  • Type-2 restriction enzyme ScaI in Streptomyces caespitosus [ChEMBL: CHEMBL5782] [UniProtKB: O52691]
Created with Highcharts 10.3.3ValuesChart context menuType-2 restriction enzyme ScaIpKd Streptomyces caespitosuspKi Streptomyces caespitosuspIC50 Streptomyces caespitosuspEC50 Streptomyces caespitosus012345Highcharts.com
  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase FYNpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase LCKpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Anti-estrogen binding site (AEBS) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL612409] [UniProtKB: Q15125, Q9UBM7]
ChEMBL Growth inhibition of multidrug resistant MCF7/Adr cells containing antiestrogen binding sites F 5 pIC50 10000 nM IC50 J Med Chem (2004) 47: 6509-6518 [PMID:15588086]
ChEMBL Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sites F 6.52 pIC50 300 nM IC50 J Med Chem (2004) 47: 6509-6518 [PMID:15588086]
ChEMBL Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sites F 6.7 pIC50 200 nM IC50 J Med Chem (2004) 47: 6509-6518 [PMID:15588086]
ChEMBL Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sites F 6.82 pIC50 150 nM IC50 J Med Chem (2004) 47: 6509-6518 [PMID:15588086]
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) B 4.87 pIC50 13590 nM IC50 DrugMatrix in vitro pharmacology data
carnitine palmitoyltransferase 2/Carnitine palmitoyltransferase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4037] [GtoPdb: 3252] [UniProtKB: P18886]
ChEMBL Inhibition of rat CPT2 in rat mitochondria B 4 pIC50 >100000 nM IC50 J Med Chem (2011) 54: 3109-3152 [PMID:21504156]
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) B 4.91 pIC50 12192 nM IC50 DrugMatrix in vitro pharmacology data
CDGSH iron-sulfur domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis B 5.46 pKi 3451 nM Ki Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay B 4.09 pIC50 80760 nM IC50 Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
DNA (cytosine-5-)-methyltransferase 3α/DNA (cytosine-5)-methyltransferase 3A in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3108652] [GtoPdb: 2750] [UniProtKB: O88508]
ChEMBL Inhibition of murine DNMT3A catalytic domain-mediated DNA methylation using 5'-6FAM-tagged 30-mer duplex DNA (17 AT bp) as substrate preincubated for 30 mins followed by enzyme addition B 5.52 pIC50 3000 nM IC50 Bioorg Med Chem Lett (2020) 30: 127296-127296 [PMID:32631516]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis B 4.7 pIC50 20000 nM IC50 J Med Chem (2010) 53: 6164-6179 [PMID:20662543]
ChEMBL Inhibition of human topoisomerase 1 B 5.49 pIC50 3200 nM IC50 Eur J Med Chem (2021) 220: 113555-113555 [PMID:34052677]
DNA topoisomerase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388]
ChEMBL Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electrophoresis B 5.52 pIC50 3000 nM IC50 Bioorg Med Chem (2017) 25: 2625-2634 [PMID:28342691]
ChEMBL Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresis B 5.52 pIC50 3000 nM IC50 Eur J Med Chem (2016) 123: 704-717 [PMID:27521587]
GtoPdb In vitro inhibition of DNA relaxation and decatenation activities in a topoisomerase extract from human placenta. - 6 pIC50 1000 nM IC50 J Nat Prod (2001) 64: 204-7 [PMID:11430001]
ChEMBL Inhibition human placenta topoisomerase 2 assessed as conversion of supercoiled pBR322 DNA to relaxed form B 6 pIC50 1000 nM IC50 J Nat Prod (2001) 64: 204-207 [PMID:11430001]
ChEMBL Inhibition human placenta topoisomerase 2 assessed as conversion of catenated kinetoplast DNA to minicircle monomer B 6 pIC50 1000 nM IC50 J Nat Prod (2001) 64: 204-207 [PMID:11430001]
ChEMBL Inhibition of human topoisomerase-2 alpha in human A498 cells assessed as decrease in relaxation of supercoiled DNA at 10 uM B 6 pIC50 990 nM IC50 Bioorg Med Chem Lett (2021) 40: 127916-127916 [PMID:33689875]
ChEMBL Inhibition of human topoisomerase 2 using supercoiled pHOT1 DNA as substrate after 30 mins by agarose gel electrophoresis B 6.06 pIC50 880 nM IC50 Eur J Med Chem (2018) 155: 117-134 [PMID:29885574]
ChEMBL Inhibition of Topo IIalpha (unknown origin) B 8.31 pIC50 4.9 nM IC50 Bioorg Med Chem (2023) 95: 117486-117486 [PMID:37847948]
DNA topoisomerase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396] [UniProtKB: Q02880]
ChEMBL Inhibition of human topoisomerase-2B after 2 hrs by ELISA B 5.46 pIC50 3500 nM IC50 Eur J Med Chem (2018) 150: 403-418 [PMID:29547830]
ChEMBL Inhibition of human topoisomerase 2beta after 2 hrs at 37 degC by ELISA B 5.46 pIC50 3500 nM IC50 Eur J Med Chem (2018) 143: 1807-1825 [PMID:29133058]
ChEMBL Inhibition of Topoisomerase II beta (unknown origin) relative to control B 6.14 pIC50 727 nM IC50 Bioorg Med Chem (2020) 28: 115674-115674 [PMID:33065442]
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer B 5.62 pIC50 2400 nM IC50 J Med Chem (2000) 43: 2100-2114 [PMID:10841789]
ChEMBL Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing B 6.05 pIC50 900 nM IC50 J Med Chem (2000) 43: 2100-2114 [PMID:10841789]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay B 4.28 pIC50 52000 nM IC50 Bioorg Med Chem Lett (2012) 22: 4844-4848 [PMID:22695131]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibitory concentration against Clostridium histolyticum Collagenase B 5.96 pIC50 1100 nM IC50 J Med Chem (1992) 35: 2768-2771 [PMID:1322986]
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells F 4.3 pIC50 50000 nM IC50 J Biol Chem (1996) 271: 9683-9689 [PMID:8621644]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.43 pKi 3693 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 4.81 pIC50 15336 nM IC50 DrugMatrix in vitro pharmacology data
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells F 5.07 pKi 8500 nM Ki Pharm Res (2001) 18: 171-176 [PMID:11405287]
ChEMBL Inhibition of P-gp-mediated multidrug resistance in doxorubicin-resistant human MCF7/ADR cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 incubated for 48 hrs by CCK-8 assay B 4.31 pIC50 49278 nM IC50 J Med Chem (2023) 66: 5550-5566 [PMID:37011035]
ChEMBL Inhibition of P-gp mediated doxorubicin resistance in human SW620/AD300 cells overexpressing P-gp measured after 48 hrs by MTT assay B 5.24 pIC50 5750 nM IC50 J Nat Prod (2022) 85: 337-344 [PMID:35073486]
ChEMBL Inhibition of P-glycoprotein overexpressed in human SW620/AD300 cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 at 2.5 uM after 48 hrs by MTT assay B 5.31 pIC50 4900 nM IC50 J Med Chem (2022) 65: 2610-2622 [PMID:35067062]
ChEMBL Inhibition of ABCB1 in human HEK293 cells B 6.3 pIC50 504 nM IC50 Eur J Med Chem (2022) 239: 114542-114542 [PMID:35751979]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells F 6.05 pIC50 886 nM IC50 Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection F 7.24 pIC50 58 nM IC50 Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Displacement of [3H]PSB0413 from human platelet P2Y12 receptor B 5 pKi >10000 nM Ki J Med Chem (2009) 52: 3784-3793 [PMID:19463000]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) B 5.6 pIC50 2485 nM IC50 DrugMatrix in vitro pharmacology data
Ribonuclease pancreatic in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6091] [UniProtKB: P61823]
ChEMBL Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentration B 4.6 pIC50 25000 nM IC50 J Nat Prod (2001) 64: 204-207 [PMID:11430001]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibition of GST-tagged Aurora A kinase expressed in insect cells assessed as inhibition of [33P]gamma-ATP incorporation in substrate after 60 mins by scintillation counting B 7.4 pIC50 40 nM IC50 Eur J Med Chem (2011) 46: 3690-3695 [PMID:21664013]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) B 4.81 pKi 15666 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) B 4.46 pIC50 34464 nM IC50 DrugMatrix in vitro pharmacology data
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 5.68 pKi 2078 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 4.9 pIC50 12468 nM IC50 DrugMatrix in vitro pharmacology data
SOS Ras/Rac guanine nucleotide exchange factor 1/Son of sevenless homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079846] [GtoPdb: 3096] [UniProtKB: Q07889]
ChEMBL Inhibition of SOS1 CD (564 to 1049 residues) (unknown origin) mediated nucleotide exchange in presence of BODIPY-FL-GDP by fluorescence based analysis B 4.34 pIC50 46000 nM IC50 J Med Chem (2023) 66: 4324-4341 [PMID:36987571]
Telomerase reverse transcriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
ChEMBL Inhibition of telomerase from human COLO201 cell B 4.14 pIC50 73000 nM IC50 J Nat Prod (2001) 64: 204-207 [PMID:11430001]
Type-2 restriction enzyme HindIII in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5004] [UniProtKB: P43870]
ChEMBL Inhibition of Haemophilus influenzae Hind 3 assessed as undigested supercoiled pBR322 DNA concentration B 4.02 pIC50 96000 nM IC50 J Nat Prod (2001) 64: 204-207 [PMID:11430001]
Type-2 restriction enzyme ScaI in Streptomyces caespitosus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5782] [UniProtKB: O52691]
ChEMBL Inhibition of Streptomyces caespitosus Sca 1 assessed as undigested supercoiled pBR322 DNA concentration B 4.6 pIC50 25000 nM IC50 J Nat Prod (2001) 64: 204-207 [PMID:11430001]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) B 5.29 pIC50 5147 nM IC50 DrugMatrix in vitro pharmacology data
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) B 4.5 pIC50 31913 nM IC50 DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]