Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	288	3q13.33	CD80	CD80 molecule
Mouse	1	306	16 26.86 cM	Cd80	CD80 antigen
Rat	-	321	11q21	Cd80	Cd80 molecule

Previous and Unofficial Names

B-lymphocyte activation antigen B7 | CD28LG | CD80 antigen

Database Links
Alphafold	P33681 (Hs), Q00609 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2364157 (Hs)
DrugBank Target	P33681 (Hs)
Ensembl Gene	ENSG00000121594 (Hs), ENSMUSG00000075122 (Mm), ENSRNOG00000001527 (Rn)
Entrez Gene	941 (Hs), 12519 (Mm), 25408 (Rn)
Human Protein Atlas	ENSG00000121594 (Hs)
KEGG Gene	hsa:941 (Hs), mmu:12519 (Mm), rno:25408 (Rn)
OMIM	112203 (Hs)
Pharos	P33681 (Hs)
RefSeq Nucleotide	NM_005191 (Hs), NM_009855 (Mm), NM_012926 (Rn)
RefSeq Protein	NP_005182 (Hs), NP_033985 (Mm), NP_037058 (Rn)
UniProtKB	P33681 (Hs), Q00609 (Mm)
Wikipedia	CD80 (Hs)

Immunopharmacology Comments

CD80 (B7-1) is expressed on dendritic cells and activated B cells and monocytes. It is required to provide a costimulatory signal necessary for T cell activation and survival. CD80 works in concert with CD86 to prime T cells. CD80 binds CD28 and CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.

Cell Type Associations

Immuno Cell Type:  Macrophages & monocytes Cell Ontology Term:   macrophage (CL:0000235) monocyte (CL:0000576)

Immuno Cell Type:  Dendritic cells Cell Ontology Term:   dendritic cell (CL:0000451)

Immuno Cell Type:  B cells Cell Ontology Term:   B cell (CL:0000236)

Immuno Cell Type:  T cells

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  Chemotaxis & migration

Immuno Process:  Cellular signalling

Immuno Process:  Barrier integrity

Immuno Disease Associations

Disease Name:  Allograft rejection Disease Synonyms:  no synonynms Comment:  CD80 is a primary target of the approved anti-rejection drug belatacept.

Disease Name:  Rheumatoid arthritis Disease Synonyms:  no synonynms Comment:  CD80 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis. Disease X-refs:  Disease Ontology: DOID:7148 OMIM: 180300 References:  3

General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.