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CD86

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2745

Nomenclature: CD86

Family: Other immune checkpoint proteins, CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 329 3q13.33 CD86 CD86 molecule
Mouse 1 309 16 25.72 cM Cd86 CD86 antigen
Rat - 313 11q22 Cd86 CD86 molecule
Previous and Unofficial Names Click here for help
CD86 antigen
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
abatacept Peptide Approved drug Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition ~7.9 pKd 2-3
pKd ~7.9 (Kd ~1.2x10-8 M) [2-3]
Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept.
belatacept Peptide Approved drug Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition - - 1
[1]
Description: IC50= 0.120µg/mL
Immunopharmacology Comments
CD86 (B7-2) is a type I membrane immunoglobulin. It is expressed on antigen-presenting cells and in association with CD80 provides the costimulatory signal necessary for T cell activation and survival. CD86 interacts with CD28 or CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept.
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
Comment:  CD86 is expressed on antigen-presenting cells.
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 6 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042104 positive regulation of activated T cell proliferation ISO
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
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GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 6 GO processes
GO:0002668 negative regulation of T cell anergy ISO
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042104 positive regulation of activated T cell proliferation ISO
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0002668 negative regulation of T cell anergy ISO
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0032743 positive regulation of interleukin-2 production NAS
GO:0032753 positive regulation of interleukin-4 production NAS
GO:0032761 positive regulation of lymphotoxin A production NAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 5 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042104 positive regulation of activated T cell proliferation ISO
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0031295 T cell costimulation IBA
GO:0042102 positive regulation of T cell proliferation IBA
GO:0042104 positive regulation of activated T cell proliferation ISO
GO:0042113 B cell activation IDA
GO:0042130 negative regulation of T cell proliferation IBA
GO:0045630 positive regulation of T-helper 2 cell differentiation NAS
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0001618 virus receptor activity IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0042113 B cell activation IDA
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GO:0002250 adaptive immune response IEA
Immuno Disease Associations
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  CD86 is a primary target of the ligand abatacept, which is clinically approved for the treatment of rheumatoid arthritis.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  3
Disease Name:  Graft versus host disease
Disease Synonyms:  no synonynms
Comment:  CD86 is a primary target of the approved anti-rejection drug belatacept.
General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

References

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1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med, 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

Other immune checkpoint proteins: CD86. Last modified on 07/08/2019. Accessed on 31/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2745.