A286982 [Ligand Id: 6592] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL19677 (A-286982) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Intercellular adhesion molecule-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3070] [UniProtKB: P05362] | ||||||||
| ChEMBL | Evaluated for its ability to block the adherence of JY-8 cells to immobilized ICAM-1. | F | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2000) 43: 4025-4040 [PMID:11052808] |
| integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096661] [GtoPdb: 2456, 2451] [UniProtKB: P05107, P05362, P20701] | ||||||||
| ChEMBL | Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical interaction assay | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2000) 43: 4025-4040 [PMID:11052808] |
| ChEMBL | Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2001) 44: 1202-1210 [PMID:11312920] |
| ChEMBL | Ability to antagonise the Leukocyte function-associated Antigen-1/ Intracellular Adhesion molecule-1 interaction (LFA-1/ICAM-1) | F | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2001) 44: 2913-2920 [PMID:11520199] |
| ChEMBL | Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assay | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 5269-5273 [PMID:20655213] |
| ChEMBL | Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(12-60) | F | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2001) 44: 4393-4403 [PMID:11728185] |
| integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Leukocyte adhesion glycoprotein LFA-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1803] [GtoPdb: 2451] [UniProtKB: P20701] | ||||||||
| ChEMBL | Inhibition of intercellular adhesion molecule-1 (ICAM-1) binding to recombinant LFA-1, range(30-60) | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2001) 44: 4393-4403 [PMID:11728185] |
| integrin αLβ2 in Human [GtoPdb: 2582] | ||||||||
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | J Med Chem (2000) 43: 4025-40 [PMID:11052808] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
