A286982 [Ligand Id: 6592] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL19677 (A-286982) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Intercellular adhesion molecule-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3070] [UniProtKB: P05362] | ||||||||
| ChEMBL | Evaluated for its ability to block the adherence of JY-8 cells to immobilized ICAM-1. | F | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2000) 43: 4025-4040 [PMID:11052808] |
| integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096661] [GtoPdb: 2456, 2451] [UniProtKB: P05107, P05362, P20701] | ||||||||
| ChEMBL | Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical interaction assay | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2000) 43: 4025-4040 [PMID:11052808] |
| ChEMBL | Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2001) 44: 1202-1210 [PMID:11312920] |
| ChEMBL | Ability to antagonise the Leukocyte function-associated Antigen-1/ Intracellular Adhesion molecule-1 interaction (LFA-1/ICAM-1) | F | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2001) 44: 2913-2920 [PMID:11520199] |
| ChEMBL | Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assay | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 5269-5273 [PMID:20655213] |
| ChEMBL | Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(12-60) | F | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2001) 44: 4393-4403 [PMID:11728185] |
| integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Leukocyte adhesion glycoprotein LFA-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1803] [GtoPdb: 2451] [UniProtKB: P20701] | ||||||||
| ChEMBL | Inhibition of intercellular adhesion molecule-1 (ICAM-1) binding to recombinant LFA-1, range(30-60) | B | 7.36 | pIC50 | 44 | nM | IC50 | J Med Chem (2001) 44: 4393-4403 [PMID:11728185] |
| integrin αLβ2 in Human [GtoPdb: 2582] | ||||||||
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | J Med Chem (2000) 43: 4025-40 [PMID:11052808] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
