integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit) | Integrins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)

  Target has curated data in GtoImmuPdb

Target id: 2456

Nomenclature: integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)

Family: Integrins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
integrin αLβ2
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 769 21q22.3 ITGB2 integrin subunit beta 2
Mouse - 771 10 C1 Itgb2 integrin beta 2
Rat - 768 20p12 Itgb2 integrin subunit beta 2
Previous and Unofficial Names
CD antigen CD18 | Integrin beta-2 | integrin, beta 2 (antigen CD18 (p95) | lymphocyte function-associated antigen 1 | LFA-1 | integrin, beta 2
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference
rovelizumab Hs Binding - - 2-3
[2-3]
Immunopharmacology Comments
ITGB2 is the beta component of the β2 integrins. It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). These integrins are essential for leukocyte extravasion to sites of infection. Their absence causes a leukocyte adhesion deficiency, which manifests clinically as recurrent severe infections, defective wound healing and neutrophilia [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 13 GO processes
GO:0001774 microglial cell activation NAS
GO:0006911 phagocytosis, engulfment ISS
GO:0006954 inflammatory response NAS
GO:0030593 neutrophil chemotaxis IDA
GO:0034142 toll-like receptor 4 signaling pathway TAS
GO:0043312 neutrophil degranulation TAS
GO:0043315 positive regulation of neutrophil degranulation IGI
GO:0050900 leukocyte migration TAS
GO:1903980 positive regulation of microglial cell activation NAS
GO:1990266 neutrophil migration IMP
click arrow to show/hide IEA associations
GO:0002523 leukocyte migration involved in inflammatory response IEA
GO:0006909 phagocytosis IEA
GO:0045123 cellular extravasation IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 3 GO processes
GO:0006911 phagocytosis, engulfment ISS
GO:0031623 receptor internalization ISS
click arrow to show/hide IEA associations
GO:0006909 phagocytosis IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0034142 toll-like receptor 4 signaling pathway TAS
GO:0043315 positive regulation of neutrophil degranulation IGI
GO:0050776 regulation of immune response TAS
GO:1903980 positive regulation of microglial cell activation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 6 GO processes
GO:0007159 leukocyte cell-cell adhesion IDA
GO:0030593 neutrophil chemotaxis IDA
GO:0050900 leukocyte migration TAS
GO:1990266 neutrophil migration IMP
click arrow to show/hide IEA associations
GO:0002523 leukocyte migration involved in inflammatory response IEA
GO:0045123 cellular extravasation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0001774 microglial cell activation NAS
GO:0034142 toll-like receptor 4 signaling pathway TAS
GO:0043312 neutrophil degranulation TAS
GO:0043315 positive regulation of neutrophil degranulation IGI
GO:1903980 positive regulation of microglial cell activation NAS
click arrow to show/hide IEA associations
GO:0030101 natural killer cell activation IEA
Clinically-Relevant Mutations and Pathophysiology
Disease:  leukocyte adhesion deficiency type 1
Description: LAD1 is an inherited immunodeficiency disease. Mutations in the β2 intergrin (ITGB2) gene lead to absent, reduced, or aberrant CD18 protein expression, resulting in subnormal levels of β2 intergrins on leukocyte membranes. This disrupts neutrophil migration (extravasion) to sites of infection resulting in recurrent infections.
OMIM: 116920
References:  1

References

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1. Kishimoto TK, Hollander N, Roberts TM, Anderson DC, Springer TA. (1987) Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell, 50 (2): 193-202. [PMID:3594570]

2. Liles WC, Dale DC, Price TH, Gaviria JM, Turner T, Saoud J, Frumkin LR. (2000) Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody. Cytokines Cell. Mol. Ther., 6 (3): 121-6. [PMID:11140880]

3. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Exp. Neurol., 153 (2): 223-33. [PMID:9784282]

How to cite this page

Integrins: integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit). Last modified on 09/06/2017. Accessed on 23/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2456.