integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | Integrins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

  Target has curated data in GtoImmuPdb

Target id: 2451

Nomenclature: integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Family: Integrins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
integrin αLβ2
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1170 16p13.1-p11 ITGAL integrin subunit alpha L
Mouse - 1163 7 F3 Itgal integrin alpha L
Rat - 1160 1q36 Itgal integrin subunit alpha L
Previous and Unofficial Names
CD11 antigen-like family member A | CD11A | Integrin alpha-L | LFA-1 | Ly-15 | Ly-21 | Lymphocyte antigen 15 | integrin, alpha L
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
BI-1950 Hs Binding 8.1 pKd 1
pKd 8.1 (Kd 9x10-9 M) [1]
Description: Inhibition of LFA-1 binding to ICAM-1 in vitro.
BIRT 377 Hs Binding 7.6 pKd 4
pKd 7.6 (Kd 2.58x10-8 M) [4]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
lifitegrast Hs Inhibition - - 2,7
[2,7]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference
efalizumab Hs Binding 11.4 pKd 3
pKd 11.4 (Kd 4x10-12 M) [3]
Description: Binding of humanized MHM24 to human CD11a on Jurkat cells.
rovelizumab Hs Binding - - 5-6
[5-6]
Immunopharmacology Comments
ITGAL associates with the beta 2 chain (ITGB2) integrin and CD18 to form the lymphocyte function-associated antigen-1 (LFA-1) complex. LFA-1 is crucial for leukocyte intercellular adhesion and costimulatory signaling in the immune system. Ligands for LFA-1 are the intercellular adhesion molecules (ICAMs) 1-3. ITGAL is the target of the withdrawn psoriasis monoclonal antibody drug efalizumab.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
GO:0006954 inflammatory response NAS
GO:0043312 neutrophil degranulation TAS
GO:0050900 leukocyte migration TAS
click arrow to show/hide IEA associations
GO:0006909 phagocytosis IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050776 regulation of immune response TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0007159 leukocyte cell-cell adhesion IMP
GO:0050900 leukocyte migration TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0006909 phagocytosis IEA

References

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1. Boehringer Ingelheim. LFA-1 (lymphocyte function-associated antigen-1) antagonist | BI-1950. Accessed on 28/11/2017. Modified on 28/11/2017. opnme.com, https://www.opnme.com/molecules/lfa-1-bi-1950

2. Breitenstein W, Huerzeler M, Kelly T, Mancuso R, Schneider G, Weitz-Schmidt G. (2015) Small molecule lfa-1 inhibitors. Patent number: WO2015189265. Assignee: Allocyte Pharmaceuticals Ag. Priority date: 12/06/2014. Publication date: 17/12/2015.

3. Jardieu PM, Presta LG. (2004) Method of treatment using humanized anti-CD11a antibodies. Patent number: US6703018. Assignee: Genentech, Inc.. Priority date: 27/11/1996. Publication date: 19/03/2004.

4. Kelly TA, Jeanfavre DD, McNeil DW, Woska Jr JR, Reilly PL, Mainolfi EA, Kishimoto KM, Nabozny GH, Zinter R, Bormann BJ et al.. (1999) Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J. Immunol., 163 (10): 5173-7. [PMID:10553036]

5. Liles WC, Dale DC, Price TH, Gaviria JM, Turner T, Saoud J, Frumkin LR. (2000) Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody. Cytokines Cell. Mol. Ther., 6 (3): 121-6. [PMID:11140880]

6. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Exp. Neurol., 153 (2): 223-33. [PMID:9784282]

7. Zhong M, Gadek TR, Bui M, Shen W, Burnier J, Barr KJ, Hanan EJ, Oslob JD, Yu CH, Zhu J et al.. (2012) Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett, 3 (3): 203-6. [PMID:24900456]

How to cite this page

Integrins: integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide). Last modified on 28/11/2017. Accessed on 16/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2451.