4-hydroxynonenal [Ligand Id: 6274] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL454280 (4-Hydroxynonenal) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5160] [GtoPdb: 485] [UniProtKB: Q6RI86] | ||||||||
| ChEMBL | Activation of TRPA1 channel in rat dorsal root ganglion neurons assessed as increase in intracellular calcium level | B | 4.11 | pEC50 | 77000 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 13519-13524 [PMID:17684094] |
| ChEMBL | Agonist activity at rat TRPA1 channel expressed in tetracycline induced HEK293 cells assessed as increase in intracellular calcium | F | 4.57 | pEC50 | 27000 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 13519-13524 [PMID:17684094] |
| ChEMBL | Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx | F | 4.57 | pEC50 | 27000 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
| GtoPdb | Calcium imaging | - | 4.6 | pEC50 | - | - | EC50 |
Proc Natl Acad Sci USA (2007) 104: 13519-24 [PMID:17684094]; J Neurosci (2007) 27: 11412-5 [PMID:17942735] |
| ChEMBL | Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influx | F | 4.7 | pEC50 | 19900 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
