Dimethylarginine dimethylaminohydrolases | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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Dimethylarginine dimethylaminohydrolases

Dimethylarginine dimethylaminohydrolases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Dimethylarginine dimethylaminohydrolases (DDAH, EC 3.5.3.18) are cytoplasmic enzymes which hydrolyse N^G,N^G-dimethyl-L-arginine to form dimethylamine and L-citrulline.

Enzymes

1247

Targets of relevance to immunopharmacology are highlighted in blue

DDAH1 (N^G,N^G-Dimethylarginine dimethylaminohydrolase 1) C Show summary »« Hide summary

Target Id

1247

Nomenclature

N^G,N^G-Dimethylarginine dimethylaminohydrolase 1

Common abbreviation

DDAH1

Previous and unofficial names

DDAHI | dimethylargininase-1 | DDAH

Genes

DDAH1 (Hs), Ddah1 (Mm), Ddah1 (Rn)

Ensembl ID

ENSG00000153904 (Hs), ENSMUSG00000028194 (Mm), ENSRNOG00000014613 (Rn)

UniProtKB AC

O94760 (Hs), Q9CWS0 (Mm), O08557 (Rn)

EC number

3.5.3.18

Cofactors

Zn²⁺

Inhibitors

compound 2e [PMID: 19013076] pK_i 5.7 [1]

DDAH2 (N^G,N^G-Dimethylarginine dimethylaminohydrolase 2) C Show summary »« Hide summary

Target Id

1248

Nomenclature

N^G,N^G-Dimethylarginine dimethylaminohydrolase 2

Common abbreviation

DDAH2

Previous and unofficial names

Genes

DDAH2 (Hs), Ddah2 (Mm), Ddah2 (Rn)

Ensembl ID

ENSG00000213722 (Hs), ENSMUSG00000007039 (Mm), ENSRNOG00000000842 (Rn)

UniProtKB AC

O95865 (Hs), Q99LD8 (Mm), Q6MG60 (Rn)

EC number

3.5.3.18

References

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How to cite this family page

Database page citation:

Dimethylarginine dimethylaminohydrolases. Accessed on 16/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=252.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.