ChEMBL ligand: CHEMBL226838 (SB-505124)
activin A receptor type 1B/Activin receptor type-1B in Human [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] There should be some charts here, you may need to enable JavaScript!
transforming growth factor beta receptor 1 in Human [GtoPdb: 1788] [UniProtKB: P36897] transforming growth factor beta receptor 1/TGF-beta receptor type-1 in Mouse [ChEMBL: CHEMBL2021750] [GtoPdb: 1788] [UniProtKB: Q64729] There should be some charts here, you may need to enable JavaScript!
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
ChEMBL	Inhibition of ALK4 (unknown origin) by radioisotopic assay	B	7.15	pIC50	70	nM	IC50	J Med Chem (2014) 57: 4213-4238 [PMID:24786585]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assay	B	6.18	pIC50	668	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5228-5231 [PMID:26483198]
ChEMBL	Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assay	B	6.23	pIC50	594	nM	IC50	Bioorg Med Chem (2011) 19: 2633-2640 [PMID:21435890]
ChEMBL	Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assay	B	6.23	pIC50	594	nM	IC50	Eur J Med Chem (2012) 57: 74-84 [PMID:23047226]
ChEMBL	Inhibition of recombinant human p38-alpha expressed in Escherichia coli using ATF2 as substrate by radioisotope-based assay	B	6.23	pIC50	590	nM	IC50	Bioorg Med Chem (2014) 22: 2724-2732 [PMID:24704197]
ChEMBL	Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radioisotopic assay	B	6.23	pIC50	590	nM	IC50	J Med Chem (2014) 57: 4213-4238 [PMID:24786585]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL	Inhibition of RIPK2 (unknown origin) by radioisotopic assay	B	6.16	pIC50	685	nM	IC50	J Med Chem (2014) 57: 4213-4238 [PMID:24786585]
transforming growth factor beta receptor 1 in Human [GtoPdb: 1788] [UniProtKB: P36897]
GtoPdb	Assay used purified human TGFβR1 kinase domain produced in Sf9 insect cells.	-	7.27	pIC50	54	nM	IC50	Eur J Med Chem (2011) 46: 3917-25 [PMID:21696866]
transforming growth factor beta receptor 1/TGF-beta receptor type-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2021750] [GtoPdb: 1788] [UniProtKB: Q64729]
ChEMBL	Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay	B	7.12	pIC50	76.6	nM	IC50	J Med Chem (2014) 57: 4213-4238 [PMID:24786585]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
ChEMBL	Antagonistic activity at TGFBR1	F	1.33	pIC50	-1.33	-	logIC50	Bioorg Med Chem Lett (2010) 20: 1918-1923 [PMID:20176484]
ChEMBL	Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells	B	6.77	pIC50	169	nM	IC50	Bioorg Med Chem (2010) 18: 4459-4467 [PMID:20472445]
ChEMBL	Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells using casein as a substrate by radioisotopic protein kinase assay	B	7.26	pIC50	54.4	nM	IC50	Eur J Med Chem (2012) 57: 74-84 [PMID:23047226]
ChEMBL	Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assay	B	7.27	pIC50	54	nM	IC50	J Med Chem (2014) 57: 4213-4238 [PMID:24786585]
ChEMBL	Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem (2011) 19: 2633-2640 [PMID:21435890]
ChEMBL	Inhibition of GST-fused recombinant human ALK5 expressed in baculovirus-infected insect Sf9 cells using casein as substrate by radioisotope-based assay	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem (2014) 22: 2724-2732 [PMID:24704197]
GtoPdb	Assay used purified human TGFβR1 kinase domain produced in Sf9 insect cells.	-	7.27	pIC50	54	nM	IC50	Eur J Med Chem (2011) 46: 3917-25 [PMID:21696866]
ChEMBL	Inhibition of GST-tagged ALK5 kinase domain (unknown origin) using GST-tagged SMAD3 as substrate in presence of [33P] gammaATP by liquid scintillation counter method	B	7.33	pIC50	47	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2070-2075 [PMID:31303386]
ChEMBL	Inhibition of ALK5 assessed as inhibition of immobilized Smad3 phosphorylation	B	7.33	pIC50	47	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4868-4872 [PMID:19616940]
ChEMBL	Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay	B	7.36	pIC50	43.8	nM	IC50	J Med Chem (2014) 57: 4213-4238 [PMID:24786585]
ChEMBL	Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase assay	B	7.46	pIC50	34.9	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5228-5231 [PMID:26483198]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibition of VEGFR2 (unknown origin) by radioisotopic assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2014) 57: 4213-4238 [PMID:24786585]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]