aloisine A [Ligand Id: 5924] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL75680 (Aloisine A)
  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
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  • Cell division control protein 28 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
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  • CFTR/Cystic fibrosis transmembrane conductance regulator in Human [ChEMBL: CHEMBL4051] [GtoPdb: 707] [UniProtKB: P13569]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
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  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
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  • protein kinase C zeta/Protein kinase C zeta in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of Casein kinase II B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Inhibition of CK1 B 4 pIC50 >=100000 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of CK2 B 4 pIC50 >=100000 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
ChEMBL Inhibition of hemagglutininin-tagged Saccharomyces cerevisiae MNY629 Cdc28/Clb2 B 5.6 pIC50 2500 nM IC50 Bioorg Med Chem (2009) 17: 5572-5582 [PMID:19596197]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
GtoPdb CDK1 in association with cyclin B - 6.82 pIC50 150 nM IC50 J Med Chem (2003) 46: 222-36 [PMID:12519061]
ChEMBL Inhibitory activity against cyclin-dependent kinase 1-cyclin B in starfish B 6.82 pIC50 150 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of CDK1/cyclinB B 6.82 pIC50 150 nM IC50 Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493P14635]
GtoPdb CDK1 in association with cyclin B - 6.82 pIC50 150 nM IC50 J Med Chem (2003) 46: 222-36 [PMID:12519061]
ChEMBL Inhibition of CDK1/cyclin B (unknown origin) B 6.82 pIC50 150 nM IC50 Eur J Med Chem (2019) 164: 615-639 [PMID:30639897]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248P24941P78396]
GtoPdb CDK2 in association with cyclin A - 6.92 pIC50 120 nM IC50 J Med Chem (2003) 46: 222-36 [PMID:12519061]
ChEMBL Inhibition of Cyclin-dependent kinase 2-cyclin A B 6.92 pIC50 120 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020P24864P24941]
ChEMBL Inhibition of Cyclin-dependent kinase 2-cyclin E B 6.4 pIC50 400 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
GtoPdb CDK2 in association with cyclin A - 6.92 pIC50 120 nM IC50 J Med Chem (2003) 46: 222-36 [PMID:12519061]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802P24385]
ChEMBL Inhibition of Cyclin-dependent kinase 4-cyclin D1 B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibitory activity against recombinant mammalian cyclin-dependent kinase 5 (p35 NCK5a) expressed in Escherichia coli B 6.7 pIC50 200 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of cyclin-dependent kinase 5/p25; range 0.16-0.2 B 6.7 pIC50 200 nM IC50 J Med Chem (2005) 48: 671-679 [PMID:15689152]
ChEMBL Inhibition of GST-fused recombinant CDK5/p25 expressed in Escherichia coli after 30 mins by scintillation counting B 6.7 pIC50 200 nM IC50 Bioorg Med Chem (2009) 17: 5572-5582 [PMID:19596197]
ChEMBL Inhibition of CDK5/p25 (unknown origin) B 6.7 pIC50 200 nM IC50 Eur J Med Chem (2019) 164: 615-639 [PMID:30639897]
ChEMBL Inhibition of Cyclin-dependent kinase 5-p35nck5a B 6.8 pIC50 160 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
GtoPdb CDK5 p35 - 6.8 pIC50 160 nM IC50 J Med Chem (2003) 46: 222-36 [PMID:12519061]
CFTR/Cystic fibrosis transmembrane conductance regulator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4051] [GtoPdb: 707] [UniProtKB: P13569]
ChEMBL Activity at human wild type CFTR expressed in CHO cells assessed as forskolin stimulated iodide flux B 6.82 pEC50 150 nM EC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Activity at human wild type CFTR expressed in Calu3 cells assessed as forskolin stimulated iodide flux B 6.85 pEC50 140 nM EC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Activity at human wild type CFTR expressed in F508del-CF1 cells assessed as forskolin stimulated iodide flux B 6.95 pEC50 111 nM EC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Inhibition of GSK3alpha B 5.82 pIC50 1500 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb - - 6.3 pIC50 500 nM IC50 J Med Chem (2003) 46: 222-36 [PMID:12519061]
ChEMBL Inhibition of Glycogen synthase kinase-3 alpha B 6.3 pIC50 500 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of Glycogen synthase kinase-3 beta B 5.82 pIC50 1500 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of GSK3-beta B 5.82 pIC50 1500 nM IC50 Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL Inhibition of glycogen synthase kinase-3 beta, purified from porcine brain or expressed in and purified from insect Sf9 cells B 6.19 pIC50 650 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of GSK3beta (unknown origin) B 6.19 pIC50 650 nM IC50 Bioorg Med Chem Lett (2014) 24: 1532-1537 [PMID:24560539]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of Insulin receptor kinase B 4.22 pIC50 60000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Inhibition of Mitogen-activated protein kinase 3 B 4.74 pIC50 18000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of Mitogen-activated protein kinase 1 B 4.66 pIC50 22000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of protein kinase C alpha B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Inhibition of Protein kinase C beta B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
ChEMBL Inhibition of Protein kinase C beta B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Inhibition of protein kinase C delta B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of protein kinase C epsilon B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL Inhibition of Protein kinase C gamma B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Inhibition of Protein kinase C mu B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Inhibition of protein kinase C zeta B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of Protein kinase PIM-1 B 5 pIC50 >10000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
ChEMBL Inhibition of RAF proto-oncogene serine/threonine-protein kinase (c-raf) B 4 pIC50 >100000 nM IC50 J Med Chem (2003) 46: 222-236 [PMID:12519061]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]