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ChEMBL ligand: CHEMBL75680 (Aloisine A) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibition of Casein kinase II | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
ChEMBL | Inhibition of CK1 | B | 4 | pIC50 | >=100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of CK2 | B | 4 | pIC50 | >=100000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546] | ||||||||
ChEMBL | Inhibition of hemagglutininin-tagged Saccharomyces cerevisiae MNY629 Cdc28/Clb2 | B | 5.6 | pIC50 | 2500 | nM | IC50 | Bioorg Med Chem (2009) 17: 5572-5582 [PMID:19596197] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
GtoPdb | CDK1 in association with cyclin B | - | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (2003) 46: 222-36 [PMID:12519061] |
ChEMBL | Inhibitory activity against cyclin-dependent kinase 1-cyclin B in starfish | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
ChEMBL | Inhibition of CDK1/cyclinB | B | 6.82 | pIC50 | 150 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
GtoPdb | CDK1 in association with cyclin B | - | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (2003) 46: 222-36 [PMID:12519061] |
ChEMBL | Inhibition of CDK1/cyclin B (unknown origin) | B | 6.82 | pIC50 | 150 | nM | IC50 | Eur J Med Chem (2019) 164: 615-639 [PMID:30639897] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
GtoPdb | CDK2 in association with cyclin A | - | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2003) 46: 222-36 [PMID:12519061] |
ChEMBL | Inhibition of Cyclin-dependent kinase 2-cyclin A | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
ChEMBL | Inhibition of Cyclin-dependent kinase 2-cyclin E | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
GtoPdb | CDK2 in association with cyclin A | - | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2003) 46: 222-36 [PMID:12519061] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
ChEMBL | Inhibition of Cyclin-dependent kinase 4-cyclin D1 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
ChEMBL | Inhibitory activity against recombinant mammalian cyclin-dependent kinase 5 (p35 NCK5a) expressed in Escherichia coli | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
ChEMBL | Inhibition of cyclin-dependent kinase 5/p25; range 0.16-0.2 | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2005) 48: 671-679 [PMID:15689152] |
ChEMBL | Inhibition of GST-fused recombinant CDK5/p25 expressed in Escherichia coli after 30 mins by scintillation counting | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem (2009) 17: 5572-5582 [PMID:19596197] |
ChEMBL | Inhibition of CDK5/p25 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2019) 164: 615-639 [PMID:30639897] |
ChEMBL | Inhibition of Cyclin-dependent kinase 5-p35nck5a | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
GtoPdb | CDK5 p35 | - | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2003) 46: 222-36 [PMID:12519061] |
CFTR/Cystic fibrosis transmembrane conductance regulator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4051] [GtoPdb: 707] [UniProtKB: P13569] | ||||||||
ChEMBL | Activity at human wild type CFTR expressed in CHO cells assessed as forskolin stimulated iodide flux | B | 6.82 | pEC50 | 150 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Activity at human wild type CFTR expressed in Calu3 cells assessed as forskolin stimulated iodide flux | B | 6.85 | pEC50 | 140 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Activity at human wild type CFTR expressed in F508del-CF1 cells assessed as forskolin stimulated iodide flux | B | 6.95 | pEC50 | 111 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Inhibition of GSK3alpha | B | 5.82 | pIC50 | 1500 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
GtoPdb | - | - | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2003) 46: 222-36 [PMID:12519061] |
ChEMBL | Inhibition of Glycogen synthase kinase-3 alpha | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of Glycogen synthase kinase-3 beta | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
ChEMBL | Inhibition of GSK3-beta | B | 5.82 | pIC50 | 1500 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL | Inhibition of glycogen synthase kinase-3 beta, purified from porcine brain or expressed in and purified from insect Sf9 cells | B | 6.19 | pIC50 | 650 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 6.19 | pIC50 | 650 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1532-1537 [PMID:24560539] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of Insulin receptor kinase | B | 4.22 | pIC50 | 60000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Inhibition of Mitogen-activated protein kinase 3 | B | 4.74 | pIC50 | 18000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
ChEMBL | Inhibition of Mitogen-activated protein kinase 1 | B | 4.66 | pIC50 | 22000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Inhibition of protein kinase C alpha | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibition of Protein kinase C beta | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
ChEMBL | Inhibition of Protein kinase C beta | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
ChEMBL | Inhibition of protein kinase C delta | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
ChEMBL | Inhibition of protein kinase C epsilon | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
ChEMBL | Inhibition of Protein kinase C gamma | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
ChEMBL | Inhibition of Protein kinase C mu | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513] | ||||||||
ChEMBL | Inhibition of protein kinase C zeta | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of Protein kinase PIM-1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
ChEMBL | Inhibition of RAF proto-oncogene serine/threonine-protein kinase (c-raf) | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 222-236 [PMID:12519061] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]