(+)-adrenaline [Ligand Id: 4450] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL42280 (L-adrenaline)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Rat [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090]
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  • α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
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  • α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
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  • α1D-adrenoceptor in Human [GtoPdb: 24] [UniProtKB: P25100]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090]
ChEMBL Binding of [3H]dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes B 4.89 pKi 13000 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833]
ChEMBL Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes B 5.43 pKi 3700 nM Ki J. Med. Chem. (2000) 43: 1611-1619 [PMID:10780918]
α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
GtoPdb - - 5 pKi - - - Mol Pharmacol (1995) 48: 250-8 [PMID:7651358]
α1B-adrenoceptor in Human [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb - - 5.1 pKi - - - Mol Pharmacol (1995) 48: 250-8 [PMID:7651358]
α1D-adrenoceptor in Human [GtoPdb: 24] [UniProtKB: P25100]
GtoPdb - - 6 pKi - - - Mol Pharmacol (1995) 48: 250-8 [PMID:7651358]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]