LTE4 [Ligand Id: 3352] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL509456 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells | F | 5.01 | pIC50 | 9830 | nM | IC50 | Mol Pharmacol (2001) 59: 1077-1085 [PMID:11306690] |
| P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
| ChEMBL | Agonist activity at human P2Y12 receptor | F | 8.89 | pEC50 | 1.3 | nM | EC50 | J Med Chem (2009) 52: 5803-5815 [PMID:19739647] |
| GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65] | ||||||||
| GtoPdb | - | - | 9.51 | pEC50 | 0.31 | nM | EC50 | PLoS ONE (2008) 3: e3579 [PMID:18974869] |
| CysLT1 receptor in Human [GtoPdb: 269] [UniProtKB: Q9Y271] | ||||||||
| GtoPdb | - | - | 7.8 | pKi | - | - | - | Mol Pharmacol (1998) 53: 750-8 [PMID:9547367] |
| GtoPdb | - | - | 6.97 | pIC50 | 107 | nM | IC50 | Nature (1999) 399: 789-93 [PMID:10391245] |
| GtoPdb | - | - | 6.41 | pEC50 | 391 | nM | EC50 | Mol Pharmacol (2011) 79: 270-8 [PMID:21078884] |
| GtoPdb | - | - | 6.67 | pEC50 | 212 | nM | EC50 | Nature (1999) 399: 789-93 [PMID:10391245] |
| GtoPdb | - | - | 7.24 | pEC50 | 58 | nM | EC50 |
Mol Pharmacol (1999) 56: 657-63 [PMID:10462554]; Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| CysLT2 receptor in Human [GtoPdb: 270] [UniProtKB: Q9NS75] | ||||||||
| GtoPdb | - | - | 6.5 | pKi | - | - | - | Mol Pharmacol (1998) 53: 750-8 [PMID:9547367] |
| GtoPdb | - | - | 5.72 | pIC50 | 1890 | nM | IC50 | Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337] |
| GtoPdb | - | - | 6.16 | pIC50 | 693 | nM | IC50 |
J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
| GtoPdb | - | - | 5.92 | pEC50 | 1208 | nM | EC50 |
J Biol Chem (2000) 275: 30531-6 [PMID:10851239]; Mol Pharmacol (2011) 79: 270-8 [PMID:21078884] |
| GtoPdb | - | - | 7.11 | pEC50 | 77 | nM | EC50 |
Biochem Biophys Res Commun (2000) 274: 316-22 [PMID:10913337]; Mol Pharmacol (2000) 58: 1601-8 [PMID:11093801] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
