mibefradil [Ligand Id: 2522] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL45816 (Mibefradil, Posicor 50, Posicor, Posicor 100)
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  • Orai1/Calcium release-activated calcium channel protein 1 in Human [ChEMBL: CHEMBL2384891] [GtoPdb: 2964] [UniProtKB: Q96D31]
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  • Nav1.2/Sodium channel protein type II alpha subunit in Rat [ChEMBL: CHEMBL3399] [GtoPdb: 579] [UniProtKB: P04775]
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  • Nav1.4/Sodium channel protein type IV alpha subunit in Rat [ChEMBL: CHEMBL3509] [GtoPdb: 581] [UniProtKB: P15390]
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  • Nav1.7/Sodium channel protein type IX alpha subunit in Human [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858]
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  • Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
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  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
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  • Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975]
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  • Cav3.1/Voltage-gated T-type calcium channel alpha-1G subunit in Human [ChEMBL: CHEMBL4641] [GtoPdb: 535] [UniProtKB: O43497]
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  • Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180]
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  • Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4]
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  • CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5]
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  • CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56]
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  • CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3]
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  • CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7]
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  • Cav2.1 in Rat [GtoPdb: 532] [UniProtKB: P54282]
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  • Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cav2.2/Cacna1b/Cacnb3 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4296086] [GtoPdb: 533] [UniProtKB: P54287Q02294]
ChEMBL Inhibition of rat Cav2.2-alpha1beta/beta3 expressed in HEK293 cells assessed as decrease in calcium mobilization response to KCl after 1 hr by Fluo-4-AM dye-based FLIPR assay B 6 pIC50 1000 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
Orai1/Calcium release-activated calcium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384891] [GtoPdb: 2964] [UniProtKB: Q96D31]
ChEMBL Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction in BAPTA-induced Ca2+ depletion-stimulated SOCE activity preincubated for 15 mins followed by BAPTA addition in presence of extracellular Ca2+ by PBX-based FLIPR assay B 4 pIC50 >100000 nM IC50 Bioorg Med Chem (2017) 25: 440-449 [PMID:27856238]
ChEMBL Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction of SERCA inhibition-induced ER release preincubated for 15 mins followed by CPA addition by PBX-based FLIPR assay B 4.28 pIC50 52100 nM IC50 Bioorg Med Chem (2017) 25: 440-449 [PMID:27856238]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA B 6.45 pKi 353 nM Ki J. Med. Chem. (2007) 50: 2931-2941 [PMID:17536794]
ChEMBL Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay B 6.72 pKi 190 nM Ki J. Med. Chem. (2007) 50: 2931-2941 [PMID:17536794]
ChEMBL Inhibition of human ERG expressed in CHO cells by IONWORKS assay B 5.48 pIC50 3300 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 119-124 [PMID:23200256]
ChEMBL Inhibition of hERG K channel F 5.74 pIC50 1800 nM IC50 Cardiovasc. Res. (2011) 91: 53-61 [PMID:21300721]
ChEMBL Inhibition of human Potassium channel HERG expressed in mammalian cells B 5.84 pIC50 1445.44 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL Inhibitory concentration against potassium channel HERG B 5.84 pIC50 1445.44 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique B 5.84 pIC50 1445.44 nM IC50 Bioorg. Med. Chem. (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL Inhibition of human ERG in MCF7 cells B 5.84 pIC50 1445.44 nM IC50 Eur. J. Med. Chem. (2009) 44: 1926-1932 [PMID:19110341]
ChEMBL Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state F 5.84 pIC50 1445.44 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1737-1741 [PMID:15745831]
ChEMBL K+ channel blocking activity in COS-7 African green monkey kidney derived cells expressing HERG Kv11.1 F 5.84 pIC50 1430 nM IC50 J. Med. Chem. (2002) 45: 3844-3853 [PMID:12190308]
ChEMBL Inhibition of human ERG B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2705-2708 [PMID:20382529]
ChEMBL Inhibitory concentration against IKr potassium channel B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL Inhibition of human hERG B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 215-219 [PMID:21126876]
ChEMBL Inhibition of human ERG B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 1887-1890 [PMID:23395659]
ChEMBL Inhibition of human ERG by patch clamp assay B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 5910-5915 [PMID:21843937]
ChEMBL Inhibition of human ERG expressed in HEK cells by patch clamp assay B 5.89 pIC50 1300 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 3941-3946 [PMID:26231163]
ChEMBL Inhibition of human ERG B 6.09 pIC50 806 nM IC50 J. Med. Chem. (2008) 51: 6471-6477 [PMID:18817368]
ChEMBL Inhibition of human ERG B 6.24 pIC50 580 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 5.74 pIC50 1800 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells F 5.74 pIC50 1800 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells F 5.8 pIC50 1600 nM IC50 Drug Metab. Dispos. (2000) 28: 895-898 [PMID:10901697]
ChEMBL Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC F 5.82 pIC50 1500 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells F 5.92 pIC50 1200 nM IC50 Mol. Pharmacol. (2002) 61: 964-973 [PMID:11961113]
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
ChEMBL Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 5 pIC50 10000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells F 5 pIC50 10000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
ChEMBL Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 5.13 pIC50 7400 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells F 5.13 pIC50 7400 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
Plasmodium yoelii yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612328]
ChEMBL Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs F 9.06 pIC50 0.87 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1215-1220 [PMID:18212104]
ChEMBL Antimalarial activity against liver stages of Plasmodium yoelii yoelii F 9.06 pIC50 0.87 nM IC50 J. Med. Chem. (2012) 55: 995-1012 [PMID:22122518]
Nav1.2/Sodium channel protein type II alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399] [GtoPdb: 579] [UniProtKB: P04775]
ChEMBL Inhibition of rat brain Nav1.2 expressed in HEK293 cells by whole cell voltage clamp method B 6.3 pIC50 500 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
Nav1.4/Sodium channel protein type IV alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3509] [GtoPdb: 581] [UniProtKB: P15390]
ChEMBL Inhibition of rat skeletal muscle Nav1.4 expressed in HEK293 cells by whole cell voltage clamp method B 6.3 pIC50 500 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
Nav1.7/Sodium channel protein type IX alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858]
ChEMBL Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage clamp method B 6.3 pIC50 500 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
ChEMBL Inhibition of human heart Nav1.5 expressed in HEK293 cells by whole cell voltage clamp method B 6.3 pIC50 500 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
GtoPdb - - 4.9 pIC50 - - - J. Pharmacol. Exp. Ther. (2000) 295: 302-8 [PMID:10991994]
ChEMBL Inhibition of Cav1.2 (unknown origin) B 6.6 pIC50 250 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
ChEMBL Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR assay B 6.69 pIC50 202 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 3941-3946 [PMID:26231163]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
ChEMBL Inhibition of Cav1.2 calcium current measured using FLIPR in rat aortic A7r5 cells F 5.96 pIC50 1100 nM IC50 IC50 data for the L-type calcium channel extracted from a set of literature articles
Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975]
ChEMBL Inhibition of N-type calcium channel Alpha-1B B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2705-2708 [PMID:20382529]
ChEMBL Antagonist activity against L-type calcium channel subunit alpha-1C assessed as inactivation of channel current by cell based patch clamp assay F 6.38 pIC50 416 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6375-6378 [PMID:20934333]
Cav3.1/Voltage-gated T-type calcium channel alpha-1G subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4641] [GtoPdb: 535] [UniProtKB: O43497]
ChEMBL Inhibition of T-type calcium channel Cav3.1 with alpha-1G subunit by patch clamp assay B 5.84 pIC50 1430 nM IC50 Bioorg. Med. Chem. (2007) 15: 365-373 [PMID:17035033]
ChEMBL Inhibition of T-type alpha1G channel expressed in HEK293 cells by whole-cell patch-clamp method B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. (2010) 18: 5938-5944 [PMID:20659804]
ChEMBL Ability to block calcium channel T type 3.1v expressed in HEK293 cells by whole cell patch clamp method F 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5244-5248 [PMID:16876404]
ChEMBL Inhibition of T-type [Ca2+] channel (alpha1G) expressed in HEK293 cells B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 283-286 [PMID:15603940]
ChEMBL Inhibition of T type calcium channel subunit alpha-1G expressed in HEK293 cells assessed as effect on T-type calcium currents by patch clamp method B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. (2007) 15: 1409-1419 [PMID:17150365]
ChEMBL Inhibition of T-type calcium channel Cav3.1 alpha-1G subunit expressed in HEK293 cells assessed as calcium current by patch-clamp assay B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 5740-5743 [PMID:17869104]
ChEMBL Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit by whole-cell patch clamp method B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 471-475 [PMID:17064894]
ChEMBL Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit and Kir2.1 potassium channel by patch-clamp assay B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 476-481 [PMID:17092715]
ChEMBL Antagonist activity at T type calcium channel alpha1G expressed in HEK293 cells assessed as inhibition of peak currents by whole-cell patch-clamp method F 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4424-4427 [PMID:18625556]
ChEMBL Inhibition of T-type calcium channel alpha1G expressed in human HEK293 cells assessed as inhibition of peak currents by whole-cell patch-clamp method B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2705-2708 [PMID:20382529]
ChEMBL Inhibition of T-type alpha1G calcium channel expressed in HEK293 cells assessed as Kcl-induced depolarization B 5.87 pIC50 1340 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 215-219 [PMID:21126876]
ChEMBL Inhibition of T-type Cav3.1 channel B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. (2010) 18: 5938-5944 [PMID:20659804]
ChEMBL Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by manual patch-clamp assay B 6.07 pIC50 860 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4219-4222 [PMID:20621730]
ChEMBL Concentration of the compounds required for inhibition of HEK293 cells (alpha1G T-type) F 6.08 pIC50 840 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 3379-3384 [PMID:15177437]
ChEMBL Inhibition of alpha-1G T-type calcium channel expressed in HEK293 cells by electrophysiological method B 6.08 pIC50 840 nM IC50 Bioorg. Med. Chem. (2007) 15: 1091-1105 [PMID:17074493]
ChEMBL Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by automated patch-clamp assay B 6.08 pIC50 830 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4219-4222 [PMID:20621730]
ChEMBL Inhibition of alpha-1G calcium channel in human HEK293 cells by whole-cell patch-clamp method B 6.08 pIC50 830 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 1887-1890 [PMID:23395659]
ChEMBL Inhibition of t-type Cav3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of 50 ms depolarizing voltage step-induced current by whole cell patch-clamp method B 6.25 pIC50 560 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 6656-6662 [PMID:24220170]
ChEMBL Inhibition of T-type CaV3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of calcium current by whole cell patch-clamp method B 6.25 pIC50 560 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1565-1570 [PMID:24529871]
GtoPdb - - 6.6 pIC50 270 nM IC50 J. Pharmacol. Exp. Ther. (2000) 295: 302-8 [PMID:10991994]
ChEMBL Inhibition of human Cav3.1 alpha1G expressed in HEK293 cells assessed as inhibition of calcium influx by FLIPR assay B 6.7 pIC50 200 nM IC50 Bioorg. Med. Chem. (2011) 19: 5628-5638 [PMID:21875808]
ChEMBL Inhibition of Cav3.1 (unknown origin) B 7.19 pIC50 64 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180]
ChEMBL Inhibition of T-type Cav3.2 channel B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. (2010) 18: 5938-5944 [PMID:20659804]
ChEMBL Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 119-124 [PMID:23200256]
ChEMBL Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR assay B 6.74 pIC50 181 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 3941-3946 [PMID:26231163]
ChEMBL Antagonist activity at human alpha1H T-type calcium channel expressed in HEK293 cells by patch clamp technique F 6.89 pIC50 130 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 474-478 [PMID:18160281]
ChEMBL Inhibition of Cav3.2 (unknown origin) B 6.89 pIC50 130 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
GtoPdb - - 7.2 pIC50 69 nM IC50 J. Pharmacol. Exp. Ther. (2000) 295: 302-8 [PMID:10991994]
ChEMBL Antagonist activity against T-type calcium channel subunit alpha-1H assessed as inactivation of channel current by cell based patch clamp assay F 7.49 pIC50 32 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6375-6378 [PMID:20934333]
Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4]
GtoPdb - - 5.8 pIC50 1500 nM IC50 J. Pharmacol. Exp. Ther. (2000) 295: 302-8 [PMID:10991994]
ChEMBL Inhibition of T-type Cav3.3 channel B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. (2010) 18: 5938-5944 [PMID:20659804]
ChEMBL Inhibition of Cav3.3 (unknown origin) B 6.89 pIC50 130 nM IC50 J Med Chem (2017) 60: 9769-9789 [PMID:29116786]
ChEMBL Inhibition of T-type calcium channel alpha1I by FLIPR B 6.9 pIC50 126 nM IC50 J. Med. Chem. (2008) 51: 6471-6477 [PMID:18817368]
CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5]
GtoPdb Patch clamp electrophysiology, kinetic rapid mixing fluometry - 4.5 pIC50 30000 nM IC50 Nature (2011) 471: 382-6 [PMID:21412338]
CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56]
GtoPdb Patch clamp electrophysiology and kinetic rapid mixing fluometry. - 4.5 pIC50 30000 nM IC50 Nature (2011) 471: 382-6 [PMID:21412338]
CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3]
GtoPdb Patch clamp electrophysiology, kinetic rapid mixing fluometry. - 4.5 pIC50 30000 nM IC50 Nature (2011) 471: 382-6 [PMID:21412338]
CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7]
GtoPdb Patch clamp electrophysiology, kinetic rapid mixing fluometry. - 4.5 pIC50 30000 nM IC50 Nature (2011) 471: 382-6 [PMID:21412338]
Cav2.1 in Rat [GtoPdb: 532] [UniProtKB: P54282]
GtoPdb - - 6.5 pIC50 - - - Neuropharmacology (2000) 39: 1-10 [PMID:10665814]
Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652]
GtoPdb - - 6.4 pIC50 - - - Neuropharmacology (2000) 39: 1-10 [PMID:10665814]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]