resiniferatoxin [Ligand Id: 2491] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL17976 (Lopain, Mtx-071, MTX-71, Neuroclastin, Resiniferatoxin, RTX) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV1 in Human [GtoPdb: 507] [UniProtKB: Q8NER1] | ||||||||
| GtoPdb | - | - | 8.4 | pEC50 | 3.98 | nM | EC50 | Eur J Pharmacol (2001) 417: 51-8 [PMID:11301059] |
| TRPV1 in Mouse [GtoPdb: 507] [UniProtKB: Q704Y3] | ||||||||
| GtoPdb | - | - | 9.8 | pEC50 | - | - | - | Neurosci Lett (2004) 370: 55-60 [PMID:15489017] |
| TRPV1 in Rat [GtoPdb: 507] [UniProtKB: O35433] | ||||||||
| GtoPdb | - | - | 7.5 | pEC50 | - | - | - | Nature (1997) 389: 816-24 [PMID:9349813] |
| Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388] | ||||||||
| GtoPdb | - | - | 5.1 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142] | ||||||||
| GtoPdb | - | - | 4.5 | pKd | 31000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| GtoPdb | - | - | 4.6 | pKd | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] | ||||||||
| GtoPdb | - | - | 4.7 | pIC50 | - | - | - | J Biol Chem (1998) 273: 5851-7 [PMID:9488722] |
| Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] | ||||||||
| GtoPdb | - | - | 4.3 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
