fluoxetine [Ligand Id: 203] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL41 (Fluoxetine, Fluoxetin ratiopharm, Fluval, NSC-283480, NSC-758685, Prozac, Sarafem, Symbyax)
  • acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
  • acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836]
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
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  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • NET/Norepinephrine transporter in Mouse [ChEMBL: CHEMBL2370] [GtoPdb: 926] [UniProtKB: O55192]
  • Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
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  • K2P2.1/Potassium channel subfamily K member 2 in Human [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069]
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  • Kv3.1/Potassium voltage-gated channel subfamily C member 1 in Rat [ChEMBL: CHEMBL2321617] [GtoPdb: 548] [UniProtKB: P25122]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • 5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9]
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  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
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  • Kir3.2 in Mouse [GtoPdb: 435] [UniProtKB: P48542]
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  • Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of human AchE B 5 pIC50 >10000 nM IC50 J Med Chem (2008) 51: 347-372 [PMID:18181565]
ChEMBL Inhibition of AChE B 6.89 pIC50 130 nM IC50 Eur J Med Chem (2010) 45: 1167-1172 [PMID:20053484]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836]
ChEMBL Inhibition of mouse brain AChE B 5 pIC50 >10000 nM IC50 J Med Chem (2019) 62: 8881-8914 [PMID:31082225]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Binding affinity for human alpha-2 adrenergic receptor expressed in CHO cell B 8.2 pKi 6.31 nM Ki J Med Chem (2001) 44: 787-805 [PMID:11262089]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 6.16 pKi 698 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 5.82 pIC50 1528 nM IC50 DrugMatrix in vitro pharmacology data
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) B 6.15 pIC50 700 nM IC50 DrugMatrix in vitro pharmacology data
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Binding affinity at dopamine receptor D2 by the inhibition of binding to [3H]spiperone in rat striatal membranes B 7 pIC50 >100 nM IC50 J Med Chem (1993) 36: 1194-1202 [PMID:8487257]
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT B 5.44 pKd 3600 nM Kd Bioorg Med Chem Lett (1998) 8: 487-492 [PMID:9871604]
ChEMBL Displacement of [125I]RTI55 from human recombinant DAT expressed in HEK293 cells B 5.18 pKi 6670 nM Ki Bioorg Med Chem (2009) 17: 337-343 [PMID:19014888]
ChEMBL Displacement of [125I]RTI-55 from human recombinant DAT expressed in HEK293 cells by scintillation counting B 5.18 pKi 6670 nM Ki J Med Chem (2009) 52: 1530-1539 [PMID:19256502]
ChEMBL Inhibition constant against dopamine transporter B 5.22 pKi 6000 nM Ki J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay B 5.42 pKi 3764 nM Ki Bioorg Med Chem Lett (2013) 23: 3411-3415 [PMID:23602445]
ChEMBL Binding inhibition towards human dopamine transporter B 5.72 pKi 1900 nM Ki J Med Chem (2005) 48: 6023-6034 [PMID:16162005]
ChEMBL Displacement of [3H]dopamine from human recombinant DAT expressed in HEK293 cells by scintillation counting B 4.71 pIC50 19500 nM IC50 J Med Chem (2009) 52: 1530-1539 [PMID:19256502]
ChEMBL Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cells B 4.71 pIC50 19500 nM IC50 Bioorg Med Chem (2009) 17: 337-343 [PMID:19014888]
ChEMBL Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay B 4.74 pIC50 18400 nM IC50 ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656]
ChEMBL Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay B 4.74 pIC50 18400 nM IC50 Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340]
ChEMBL Binding Assay: DA transporter binding assay for evaluating binding of the compound to the dopamine transporter was carried out using human recombinant dopamine transporter membrane (PerkinElmer Life and Analytical Sciences, USA) expressed in CHO-K1 cells and radioisotope [3H]WIN35,428 (PerkinElmer).That is, the test drug, 8 nM [3H]WIN35,428, dopamine transporter membrane (23 ug/well), and 50 mM Tris-HCl buffer (pH 7.4) containing 100 mM NaCl were added to obtain a reaction mixture with a final volume of 0.25 ml. After incubation for 120 minutes at 4° C., the mixture was quickly passed through a Filtermat A glass fiber filter pre-soaked with 0.5% (w/v) PEI (polyethyleneimine) using Inotech Harvester (Inotech) to terminate the reaction. After washing with cold washing buffer (50 mM Tris-HCl, pH 7.4, 0.9% NaCl) solution, the filter was covered with MeltiLex and sealed in a sample bag. After drying in an oven, radioactivity was counted using MicroBeta Plus (Wallac). B 5 pIC50 >10000 nM IC50 US-9120771-B2. Azetidine derivative and antidepressant composition including the same (2015)
ChEMBL Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay B 5.04 pIC50 9120.11 nM IC50 Bioorg Med Chem Lett (2013) 23: 3411-3415 [PMID:23602445]
ChEMBL Inhibition of dopamine uptake at human DAT in human HEK293 cells B 5.22 pIC50 6000 nM IC50 Bioorg Med Chem Lett (2008) 18: 4224-4227 [PMID:18550369]
ChEMBL Inhibition of dopamine uptake at human DAT expressed in HEK cells B 5.22 pIC50 6000 nM IC50 Bioorg Med Chem Lett (2008) 18: 4495-4498 [PMID:18667309]
ChEMBL Inhibition of DA transporter expressed in HEK293 cells B 5.36 pIC50 4400 nM IC50 Bioorg Med Chem Lett (2006) 16: 4345-4348 [PMID:16750359]
ChEMBL Inhibition of [3H]DA reuptake at DA transporter in HEK293 cells B 5.36 pIC50 4400 nM IC50 Bioorg Med Chem Lett (2006) 16: 4349-4353 [PMID:16750363]
DAT/Dopamine transporter in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2799] [GtoPdb: 927] [UniProtKB: Q61327]
ChEMBL Tested in vitro for dopamine(DA) neuronal uptake inhibition B 5.7 pKi >2000 nM Ki J Med Chem (1990) 33: 2793-2797 [PMID:2213832]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Ability to inhibit high affinity reuptake of [3H]DA from dopamine transporter into nerve endings synaptosomes B 5.34 pKi 4580 nM Ki J Med Chem (2002) 45: 1930-1941 [PMID:11960503]
ChEMBL Inhibition of [3H]- DA reuptake into rat striatal synaptosomes B 5.52 pKi 3050 nM Ki Bioorg Med Chem Lett (1998) 8: 487-492 [PMID:9871604]
ChEMBL Inhibition of [3H]DA uptake by dopamine transporter of rat striata synaptosomes B 5.6 pKi >2500 nM Ki J Med Chem (2000) 43: 1215-1222 [PMID:10737754]
ChEMBL Inhibition of [3H]DA uptake at Dopamine transporter into rat nerve endings (synaptosomes) B 5.6 pKi >2500 nM Ki Bioorg Med Chem Lett (2000) 10: 2741-2743 [PMID:11133081]
ChEMBL Inhibition of DAT in rat striatum assessed as [3H]dopamine accumulation B 5.96 pKi 1092 nM Ki J Med Chem (2011) 54: 2924-2932 [PMID:21446715]
ChEMBL Displacement of [3H]-dopamine from rat striatum DAT after 5 mins B 5.96 pKi 1092 nM Ki Bioorg Med Chem (2014) 22: 311-324 [PMID:24315194]
ChEMBL Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometry B 5.22 pIC50 6000 nM IC50 Bioorg Med Chem Lett (2009) 19: 58-61 [PMID:19038547]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) B 5 pKi 10066 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) B 4.91 pIC50 12286.4 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Displacement of [3H]astemizole from human ERG B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2020) 30: 126882-126882 [PMID:31889666]
ChEMBL Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cells B 5.51 pIC50 3100 nM IC50 Bioorg Med Chem (2010) 18: 6156-6169 [PMID:20637635]
ChEMBL Inhibition of human Potassium channel HERG expressed in mammalian cells B 5.82 pIC50 1513.56 nM IC50 Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL Inhibitory concentration against potassium channel HERG B 5.82 pIC50 1513.56 nM IC50 Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique B 5.82 pIC50 1513.56 nM IC50 Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL Inhibition of human ERG B 6.34 pIC50 457.09 nM IC50 Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL Inhibition of human ERG B 8 pIC50 10 nM IC50 J Med Chem (2013) 56: 8955-8971 [PMID:23919353]
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL Binding affinity to human histamine H3 receptor B 5.14 pKi 7300 nM Ki Bioorg Med Chem Lett (2007) 17: 702-706 [PMID:17107798]
ChEMBL Binding affinity to human histamine H3 receptor B 5.14 pKi 7300 nM Ki Bioorg Med Chem Lett (2007) 17: 4799-4803 [PMID:17616397]
ChEMBL Binding affinity at human histamine H3 receptor B 5.14 pKi 7300 nM Ki Bioorg Med Chem Lett (2007) 17: 1047-1051 [PMID:17127059]
ChEMBL Displacement of N-[3H]alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells B 5.14 pKi 7300 nM Ki Bioorg Med Chem Lett (2007) 17: 2566-2569 [PMID:17307358]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.11 pKi 771 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.49 pIC50 3203 nM IC50 DrugMatrix in vitro pharmacology data
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.12 pKi 762 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.44 pIC50 3595 nM IC50 DrugMatrix in vitro pharmacology data
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.01 pKi 976 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.87 pIC50 1358 nM IC50 DrugMatrix in vitro pharmacology data
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter B 6.62 pKd 240 nM Kd Bioorg Med Chem Lett (1998) 8: 487-492 [PMID:9871604]
ChEMBL Inhibition constant against norepinephrine transporter B 5.7 pKi 2000 nM Ki J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL Displacement of [125I]RTI55 from human recombinant NET expressed in HEK293 cells B 5.81 pKi 1560 nM Ki Bioorg Med Chem (2009) 17: 337-343 [PMID:19014888]
ChEMBL Displacement of [125I]RTI-55 from human recombinant NET expressed in HEK293 cells by scintillation counting B 5.81 pKi 1560 nM Ki J Med Chem (2009) 52: 1530-1539 [PMID:19256502]
ChEMBL Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay B 5.86 pKi 1394 nM Ki Bioorg Med Chem Lett (2013) 23: 3411-3415 [PMID:23602445]
ChEMBL DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) B 5.89 pKi 1292 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL Binding inhibition towards human norepinephrine transporter B 6.36 pKi 440 nM Ki J Med Chem (2005) 48: 6023-6034 [PMID:16162005]
ChEMBL Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay B 5.2 pIC50 6309.57 nM IC50 Bioorg Med Chem Lett (2013) 23: 3411-3415 [PMID:23602445]
ChEMBL Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cells B 5.28 pIC50 5200 nM IC50 Bioorg Med Chem Lett (2006) 16: 4345-4348 [PMID:16750359]
ChEMBL Inhibition of [3H]NA reuptake at NA transporter in HEK293 cells B 5.28 pIC50 5200 nM IC50 Bioorg Med Chem Lett (2006) 16: 4349-4353 [PMID:16750363]
ChEMBL Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay B 5.36 pIC50 4410 nM IC50 ACS Med Chem Lett (2014) 5: 999-1004 [PMID:25221656]
ChEMBL Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay B 5.36 pIC50 4410 nM IC50 Bioorg Med Chem Lett (2014) 24: 3234-3237 [PMID:24974340]
ChEMBL Binding Assay: NE transporter binding assay for evaluating binding of the compound to the norepinephrine transporter was carried out using human recombinant norepinephrine transporter membrane (PerkinElmer Life and Analytical Sciences, USA) expressed in MDCK cells and radioisotope [3H]Nisoxetine (PerkinElmer).That is, the test drug, 6 nM [3H]Nisoxetine, norepinephrine transporter membrane (11 ug/well), 120 mM NaCl and 50 mM Tris-HCl buffer (pH 7.4) containing 5 mM KCl were added to obtain a reaction mixture with a final volume of 0.25 ml. After incubation for 60 minutes at 4° C., the mixture was quickly passed through a Filtermat A glass fiber filter pre-soaked with 0.5% (w/v) PEI (polyethyleneimine) using Inotech Harvester (Inotech) to terminate the reaction. After washing with cold washing buffer (50 mM Tris-HCl, pH 7.4, 0.9% NaCl) solution, the filter was covered with MeltiLex and sealed in a sample bag. After drying in an oven, radioactivity was counted using MicroBeta Plus (Wallac). B 5.6 pIC50 2535 nM IC50 US-9120771-B2. Azetidine derivative and antidepressant composition including the same (2015)
ChEMBL Inhibition of norepinephrine uptake at human NET expressed in HEK cells