AH6809 [Ligand Id: 1896] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1317823 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| IP receptor/Prostacyclin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| ChEMBL | Antagonist activity at prostanoid IP receptor (unknown origin) by functional cAMP assay | F | 4 | pKi | >100000 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| DP1 receptor/Prostaglandin D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Antagonist activity at DP1 receptor (unknown origin) by functional cAMP assay | F | 5.85 | pKi | 1400 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP1 receptor/Prostaglandin E2 receptor EP1 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Antagonist activity at EP1 receptor (unknown origin) by functional cAMP assay | F | 5.92 | pKi | 1200 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| GtoPdb | - | - | 6 | pKi | - | - | - |
Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132] |
| EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597] | ||||||||
| GtoPdb | - | - | 5.9 | pKi | - | - | - | Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820] |
| EP2 receptor/Prostaglandin E2 receptor EP2 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| GtoPdb | - | - | 5.9 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assay | F | 5.94 | pKi | 1150 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| ChEMBL | Inhibition of EP2 receptor (unknown origin) by competitive binding assay | B | 5.94 | pKi | 1150 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053] | ||||||||
| GtoPdb | - | - | 6.5 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
| EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928] | ||||||||
| GtoPdb | - | - | 6.3 | pKi | - | - | - | Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820] |
| EP3 receptor/Prostaglandin E2 receptor EP3 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| ChEMBL | Antagonist activity at EP3 receptor (unknown origin) by functional cAMP assay | F | 5.8 | pKi | 1600 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| GtoPdb | - | - | 5.8 | pKi | 1600 | nM | Ki | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| EP4 receptor/Prostaglandin E2 receptor EP4 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Antagonist activity at EP4 receptor (unknown origin) by functional cAMP assay | F | 4 | pKi | >100000 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
