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ChEMBL ligand: CHEMBL148319 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
ChEMBL | In vitro transactivation of human Peroxisome proliferator activated receptor alpha (hPPARalpha) | B | 6.02 | pEC50 | 960 | nM | EC50 | J Med Chem (2003) 46: 4883-4894 [PMID:14584939] |
ChEMBL | In vitro transactivation using receptor transactivation assay against hPPAR alpha | F | 6.47 | pEC50 | 340 | nM | EC50 | J Med Chem (2002) 45: 789-804 [PMID:11831892] |
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
ChEMBL | In vitro transcriptional activation of hPPAR delta | F | 5.62 | pEC50 | 2410 | nM | EC50 | J Med Chem (2002) 45: 789-804 [PMID:11831892] |
ChEMBL | In vitro transactivation of human Peroxisome proliferator activated receptor delta (hPPARdelta) | B | 5.73 | pEC50 | 1880 | nM | EC50 | J Med Chem (2003) 46: 4883-4894 [PMID:14584939] |
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
ChEMBL | In vitro transactivation of human Peroxisome proliferator activated receptor gamma | B | 5.1 | pEC50 | 7910 | nM | EC50 | J Med Chem (2003) 46: 4883-4894 [PMID:14584939] |
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
GtoPdb | - | - | 6.9 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
GtoPdb | - | - | 7.6 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
GtoPdb | - | - | 6 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053] | ||||||||
GtoPdb | - | - | 5.8 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
EP3 receptor in Human [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
GtoPdb | - | - | 7.85 | pKi | 14 | nM | Ki | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557] | ||||||||
GtoPdb | - | - | 7.51 | pKi | 31 | nM | Ki | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
GtoPdb | - | - | 6.5 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
EP4 receptor in Mouse [GtoPdb: 343] [UniProtKB: P32240] | ||||||||
GtoPdb | - | - | 5.6 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
GtoPdb | - | - | 6.5 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117] | ||||||||
GtoPdb | - | - | 5.9 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
GtoPdb | - | - | 6.6 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
IP receptor in Mouse [GtoPdb: 345] [UniProtKB: P43252] | ||||||||
GtoPdb | - | - | 7 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
GtoPdb | - | - | 4.7 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]