butaprost (free acid form) [Ligand Id: 1892] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1628262
  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat02468Highcharts.com
  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
  • EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat01234567Highcharts.com
  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
  • EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat0123456Highcharts.com
  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid IP receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
Created with Highcharts 10.3.3ValuesChart context menuDP1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731]
Created with Highcharts 10.3.3ValuesChart context menuTP receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Binding affinity to EP1 receptor (unknown origin) B 5 pKi >10000 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
GtoPdb - - 7 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944];
Mol Pharmacol (1999) 56: 545-51 [PMID:10462542]
ChEMBL Binding affinity to EP2 receptor (unknown origin) by competitive binding assay B 7.14 pKi 73 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL Agonist activity at EP2 receptor (unknown origin) by functional assay B 7.49 pEC50 32 nM EC50 J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 7.2 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Binding affinity to EP3 receptor (unknown origin) B 5 pKi >10000 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
GtoPdb - - 5.78 pKi 1643 nM Ki Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb - - 4.93 pKi 11800 nM Ki Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 4.7 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
ChEMBL Binding affinity to EP4 receptor (unknown origin) B 5 pKi >10000 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
GtoPdb - - 4.8 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
GtoPdb - - 4.3 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
ChEMBL Binding affinity to prostanoid IP receptor (unknown origin) B 6.06 pKi 870 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL Agonist activity at prostanoid IP receptor (unknown origin) by functional assay B 7.6 pIC50 25 nM IC50 J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 4.9 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731]
GtoPdb - - 4.7 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]