ChEMBL ligand: CHEMBL548 (Cervidil, Dinoprostone, Dinoprostone beta-cyclodextrin clathrate, Enzaprost e, Minprostin e2, NSC-165560, NSC-196514, Prepidil, Propess, Prostaglandin e2, Prostin e2, U-12,062, U-12062)
EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] EP1 receptor/Prostanoid EP1 receptor in Mouse [ChEMBL: CHEMBL2181] [GtoPdb: 340] [UniProtKB: P35375] EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597] There should be some charts here, you may need to enable JavaScript!
EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] EP2 receptor/Prostanoid EP2 receptor in Mouse [ChEMBL: CHEMBL2488] [GtoPdb: 341] [UniProtKB: Q62053] EP2 receptor/Prostanoid EP2 receptor in Rat [ChEMBL: CHEMBL4909] [GtoPdb: 341] [UniProtKB: Q62928] There should be some charts here, you may need to enable JavaScript!
EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] EP3 receptor/Prostanoid EP3 receptor in Mouse [ChEMBL: CHEMBL4336] [GtoPdb: 342] [UniProtKB: P30557] EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980] There should be some charts here, you may need to enable JavaScript!
EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] EP4 receptor/Prostanoid EP4 receptor in Mouse [ChEMBL: CHEMBL2489] [GtoPdb: 343] [UniProtKB: P32240] EP4 receptor/Prostanoid EP4 receptor in Rat [ChEMBL: CHEMBL4086] [GtoPdb: 343] [UniProtKB: P43114] There should be some charts here, you may need to enable JavaScript!
FP receptor/Prostanoid FP receptor in Human [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117] There should be some charts here, you may need to enable JavaScript!
IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] There should be some charts here, you may need to enable JavaScript!
OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69] There should be some charts here, you may need to enable JavaScript!
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258] There should be some charts here, you may need to enable JavaScript!
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4] DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6] There should be some charts here, you may need to enable JavaScript!
TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731] There should be some charts here, you may need to enable JavaScript!
CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5] There should be some charts here, you may need to enable JavaScript!
CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56] There should be some charts here, you may need to enable JavaScript!
CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3] There should be some charts here, you may need to enable JavaScript!
CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL	Binding affinity to EP1 receptor (unknown origin)	B	7.74	pKi	18	nM	Ki	J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
GtoPdb	-	-	8	pKi	-	-	-	Br J Pharmacol (2006) 148: 326-39 [PMID:16604093]; Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132]
ChEMBL	Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293 cells	B	8.04	pKi	9.1	nM	Ki	Bioorg Med Chem Lett (2007) 17: 4323-4327 [PMID:17531488]
ChEMBL	Displacement of [3H]PGE2 from human EP1 receptor	B	8.04	pKi	9.1	nM	Ki	Bioorg Med Chem Lett (2008) 18: 821-824 [PMID:18039575]
ChEMBL	Binding affinity to EP1 receptor	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis	F	8.43	pEC50	3.7	nM	EC50	ACS Med Chem Lett (2016) 7: 306-311 [PMID:26985320]
EP1 receptor/Prostanoid EP1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2181] [GtoPdb: 340] [UniProtKB: P35375]
GtoPdb	-	-	7.7	pKi	-	-	-	Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]; Endocrinology (2000) 141: 1554-9 [PMID:10746663]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2012) 22: 396-401 [PMID:22119471]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 60 mins by scintillation counting	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2012) 20: 2235-2251 [PMID:22386979]
EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
GtoPdb	-	-	7.7	pKi	-	-	-	Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL	Binding affinity to EP2 receptor (unknown origin) by competitive binding assay	B	7.42	pKi	38	nM	Ki	J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
GtoPdb	-	-	8.3	pKi	5.01	nM	Ki	Br J Pharmacol (2006) 148: 326-39 [PMID:16604093]; Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; Mol Pharmacol (1999) 56: 545-51 [PMID:10462542]
ChEMBL	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	B	8.31	pKi	4.9	nM	Ki	Bioorg Med Chem Lett (2007) 17: 4323-4327 [PMID:17531488]
ChEMBL	Binding affinity at human prostaglandin EP2 receptor	B	8.31	pKi	4.9	nM	Ki	Bioorg Med Chem Lett (2007) 17: 6572-6575 [PMID:17931866]
ChEMBL	Displacement of [3H]PGE2 from human EP2 receptor	B	8.31	pKi	4.9	nM	Ki	Bioorg Med Chem Lett (2008) 18: 821-824 [PMID:18039575]
ChEMBL	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assay	B	8.77	pKi	1.7	nM	Ki	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	B	8.99	pKi	1.03	nM	Ki	J Med Chem (2019) 62: 4731-4741 [PMID:30964292]
ChEMBL	Binding affinity to EP2 receptor	B	7.42	pIC50	37.7	nM	IC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	B	8.4	pIC50	4	nM	IC50	J Med Chem (2018) 61: 6869-6891 [PMID:29995405]
ChEMBL	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assay	B	8.48	pIC50	3.3	nM	IC50	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	B	8.59	pIC50	2.6	nM	IC50	Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801]
ChEMBL	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	B	8.59	pIC50	2.6	nM	IC50	Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250]
ChEMBL	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	B	8.66	pIC50	2.2	nM	IC50	Bioorg Med Chem (2013) 21: 2764-2771 [PMID:23582449]
ChEMBL	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	B	6.46	pEC50	346	nM	EC50	ACS Med Chem Lett (2016) 7: 306-311 [PMID:26985320]
ChEMBL	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	F	6.48	pEC50	331	nM	EC50	J Med Chem (2019) 62: 4731-4741 [PMID:30964292]
ChEMBL	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	F	8.03	pEC50	9.3	nM	EC50	J Med Chem (2019) 62: 4731-4741 [PMID:30964292]
ChEMBL	Agonist activity at EP2 receptor (unknown origin) by functional assay	B	8.68	pEC50	2.1	nM	EC50	J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	F	8.72	pEC50	1.9	nM	EC50	ACS Med Chem Lett (2016) 7: 306-311 [PMID:26985320]
EP2 receptor/Prostanoid EP2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2488] [GtoPdb: 341] [UniProtKB: Q62053]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2012) 22: 396-401 [PMID:22119471]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2012) 20: 2235-2251 [PMID:22386979]
GtoPdb	-	-	7.9	pKi	-	-	-	Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]; Endocrinology (2000) 141: 1554-9 [PMID:10746663]; Life Sci (2003) 74: 135-41 [PMID:14607240]
EP2 receptor/Prostanoid EP2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4909] [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb	-	-	8.2	pKi	-	-	-	Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
ChEMBL	Inhibition of rat EP2 receptor expressed in HEK293 cells	B	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2075-2078 [PMID:19250823]
ChEMBL	Agonist activity at rat EP2 receptor	F	7.72	pEC50	19	nM	EC50	Bioorg Med Chem (2012) 20: 2235-2251 [PMID:22386979]
ChEMBL	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	F	9.7	pEC50	0.2	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2075-2078 [PMID:19250823]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
GtoPdb	-	-	8.68	pKd	2.1	nM	Kd	Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791]
GtoPdb	-	-	9.1	pKd	0.8	nM	Kd	Br J Pharmacol (2006) 148: 326-39 [PMID:16604093]; Biochem Pharmacol (2012) 84: 68-75 [PMID:22480736]; Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791]
ChEMBL	Binding affinity to EP3 receptor (unknown origin)	B	8.3	pKi	5	nM	Ki	J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL	Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	B	8.66	pKi	2.17	nM	Ki	J Med Chem (2019) 62: 4731-4741 [PMID:30964292]
GtoPdb	-	-	9.48	pKi	0.33	nM	Ki	Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
ChEMBL	Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cells	B	9.48	pKi	0.33	nM	Ki	Bioorg Med Chem Lett (2007) 17: 4323-4327 [PMID:17531488]
ChEMBL	Displacement of [3H]PGE2 from human EP3 receptor	B	9.48	pKi	0.33	nM	Ki	Bioorg Med Chem Lett (2008) 18: 821-824 [PMID:18039575]
ChEMBL	Binding affinity to EP3 receptor	B	9.03	pIC50	0.94	nM	IC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis	F	8.6	pEC50	2.5	nM	EC50	ACS Med Chem Lett (2016) 7: 306-311 [PMID:26985320]
EP3 receptor/Prostanoid EP3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4336] [GtoPdb: 342] [UniProtKB: P30557]
GtoPdb	-	-	8.85	pKd	1.4	nM	Kd	Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	B	8.3	pKi	5	nM	Ki	Bioorg Med Chem Lett (2012) 22: 396-401 [PMID:22119471]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting	B	8.3	pKi	5	nM	Ki	Bioorg Med Chem (2012) 20: 2235-2251 [PMID:22386979]
GtoPdb	-	-	9.07	pKi	0.85	nM	Ki	Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb	-	-	8.41	pKd	3.9	nM	Kd	FEBS Lett (1994) 351: 119-22 [PMID:8076679]; Br J Pharmacol (2005) 145: 1132-42 [PMID:15937517]
GtoPdb	-	-	8.96	pKd	1.1	nM	Kd	Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791]
GtoPdb	-	-	9.1	pKd	0.8	nM	Kd	Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]; Br J Pharmacol (2005) 145: 1132-42 [PMID:15937517]; Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791]
GtoPdb	-	-	9	pKi	-	-	-	Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
GtoPdb	-	-	9.39	pEC50	0.41	nM	EC50	Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL	Binding affinity to EP4 receptor (unknown origin)	B	8.51	pKi	3.1	nM	Ki	J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL	Displacement of radiolabeled PGE2 from human prostanoid EP4 receptor	B	8.72	pKi	1.9	nM	Ki	J Med Chem (2008) 51: 7094-7098 [PMID:18983139]
GtoPdb	-	-	9.1	pKi	0.79	nM	Ki	Br J Pharmacol (2006) 148: 326-39 [PMID:16604093]; Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; Mol Pharmacol (1999) 56: 545-51 [PMID:10462542]; Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683]; J Pharmacol Exp Ther (2007) 322: 686-94 [PMID:17495127]
ChEMBL	Binding affinity at human prostaglandin EP4 receptor	B	9.1	pKi	0.79	nM	Ki	Bioorg Med Chem Lett (2007) 17: 6572-6575 [PMID:17931866]
ChEMBL	Displacement of [3H]PGE4 from human EP4 receptor	B	9.1	pKi	0.79	nM	Ki	Bioorg Med Chem Lett (2008) 18: 821-824 [PMID:18039575]
ChEMBL	Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells	B	9.1	pKi	0.79	nM	Ki	Bioorg Med Chem Lett (2007) 17: 4323-4327 [PMID:17531488]
ChEMBL	Displacement of [3H]PGE2 from human recombinant prostanoid EP4 receptor in CHEM1 cells after 2 hrs	B	9.35	pKi	0.45	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Binding affinity to human prostanoid EP4 receptor by radioligand displacement assay	B	9.77	pKi	0.17	nM	Ki	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	B	9.96	pKi	0.11	nM	Ki	J Med Chem (2019) 62: 4731-4741 [PMID:30964292]
ChEMBL	Binding affinity to EP4 receptor	B	8	pIC50	9.9	nM	IC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL	Displacement of radiolabeled PGE2 from human prostanoid EP4 receptor	B	8.42	pIC50	3.8	nM	IC50	J Med Chem (2008) 51: 7094-7098 [PMID:18983139]
ChEMBL	Displacement of [3H]PGE2 from human recombinant prostanoid EP4 receptor in CHEM1 cells after 2 hrs	B	8.96	pIC50	1.1	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells	B	9.15	pIC50	0.7	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927]
ChEMBL	Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	B	9.26	pIC50	0.55	nM	IC50	Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250]
ChEMBL	Binding affinity to human prostanoid EP4 receptor by radioligand displacement assay	B	9.35	pIC50	0.45	nM	IC50	Eur J Med Chem (2013) 63: 85-94 [PMID:23466604]
GtoPdb	-	-	6.05	pEC50	900	nM	EC50	J Pharmacol Exp Ther (2009) 331: 297-307 [PMID:19584306]
ChEMBL	Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	F	8.12	pEC50	7.5	nM	EC50	ACS Med Chem Lett (2016) 7: 306-311 [PMID:26985320]
ChEMBL	EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor	F	8.52	pEC50	3	nM	EC50	Bioorg Med Chem Lett (2003) 13: 1129-1132 [PMID:12643927]
ChEMBL	Agonist activity at human EP4 receptor by cAMP assay	F	8.52	pEC50	3	nM	EC50	Bioorg Med Chem Lett (2008) 18: 821-824 [PMID:18039575]
ChEMBL	Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	F	9.23	pEC50	0.58	nM	EC50	J Med Chem (2019) 62: 4731-4741 [PMID:30964292]
ChEMBL	Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	F	10.7	pEC50	0.02	nM	EC50	J Med Chem (2019) 62: 4731-4741 [PMID:30964292]
EP4 receptor/Prostanoid EP4 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2489] [GtoPdb: 343] [UniProtKB: P32240]
GtoPdb	-	-	8.6	pKd	2.5	nM	Kd	Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	B	8.51	pKi	3.1	nM	Ki	Bioorg Med Chem Lett (2012) 22: 396-401 [PMID:22119471]
ChEMBL	Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting	B	8.51	pKi	3.1	nM	Ki	Bioorg Med Chem (2012) 20: 2235-2251 [PMID:22386979]
GtoPdb	-	-	8.7	pKi	2	nM	Ki	Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]; Endocrinology (2000) 141: 1554-9 [PMID:10746663]
EP4 receptor/Prostanoid EP4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4086] [GtoPdb: 343] [UniProtKB: P43114]
GtoPdb	-	-	9	pKi	-	-	-	Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
ChEMBL	Inhibition of rat EP4 receptor expressed in HEK293 cells	B	8.68	pIC50	2.1	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2075-2078 [PMID:19250823]
ChEMBL	Agonist activity at rat EP4 receptor	F	8.46	pEC50	3.5	nM	EC50	Bioorg Med Chem (2012) 20: 2235-2251 [PMID:22386979]
ChEMBL	Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	F	9.15	pEC50	0.7	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2075-2078 [PMID:19250823]
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
GtoPdb	-	-	6.9	pKi	-	-	-	Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; Biochem J (2003) 371: 443-9 [PMID:12519077]
ChEMBL	Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis	F	6.6	pEC50	250	nM	EC50	ACS Med Chem Lett (2016) 7: 306-311 [PMID:26985320]
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
GtoPdb	-	-	7	pKi	-	-	-	Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL	Binding affinity to prostanoid IP receptor (unknown origin)	B	5	pKi	>10000	nM	Ki	J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL	Agonist activity at prostanoid IP receptor (unknown origin) by functional assay	B	6.59	pIC50	260	nM	IC50	J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL	Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	F	6.46	pEC50	347	nM	EC50	ACS Med Chem Lett (2016) 7: 306-311 [PMID:26985320]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	4.74	pKi	18197.01	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	4.74	pKi	18000	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
ChEMBL	Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr	B	5.47	pKi	3400	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr	B	5.47	pKi	3388.44	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb	-	-	7	pKi	-	-	-	J Biol Chem (1995) 270: 18910-6 [PMID:7642548]; Br J Pharmacol (1998) 123: 1317-24 [PMID:9579725]; Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb	-	-	5.3	pKi	-	-	-	Br J Pharmacol (2002) 137: 1163-72 [PMID:12466225]
DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
GtoPdb	-	-	5.5	pKi	-	-	-	J Pharmacol Exp Ther (2003) 306: 463-70 [PMID:12721327]
TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731]
GtoPdb	-	-	4.5	pKi	-	-	-	Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5]
GtoPdb	Patch clamp electrophysiology	-	6.3	pEC50	500	nM	EC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56]
GtoPdb	Patch clamp electrophysiology.	-	6.3	pEC50	500	nM	EC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3]
GtoPdb	Patch clamp electrophysiology.	-	6.3	pEC50	500	nM	EC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7]
GtoPdb	Patch clamp electrophysiology.	-	6.3	pEC50	500	nM	EC50	Nature (2011) 471: 387-91 [PMID:21412339]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]