eupatorin [Ligand Id: 13862] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL487402 (Eupatorin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP1B1/Cytochrome P450 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4878] [GtoPdb: 1320] [UniProtKB: Q16678] | ||||||||
| ChEMBL | Inhibition of CYP1B1 (unknown origin) | B | 7.46 | pKi | 35 | nM | Ki | Eur J Med Chem (2017) 135: 296-306 [PMID:28458135] |
| GtoPdb | - | - | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2011) 19: 2842-9 [PMID:21482471] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated for 1 hr by Z'-LYTE assay | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Nat Prod (2021) 84: 1-10 [PMID:33393294] |
| GtoPdb | - | - | 5.96 | pIC50 | 1100 | nM | IC50 | J Nat Prod (2021) 84: 1-10 [PMID:33393294] |
| CYP1A1 in Human [GtoPdb: 1318] [UniProtKB: P04798] | ||||||||
| GtoPdb | - | - | 6.68 | pKi | 210 | nM | Ki | Bioorg Med Chem (2011) 19: 2842-9 [PMID:21482471] |
| kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| GtoPdb | PubChem BioAssay data | - | 6.1 | pKi | 794 | nM | Ki | |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
