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CYP1A1

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Target not currently curated in GtoImmuPdb

Target id: 1318

Nomenclature: CYP1A1

Family: CYP1 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 512 15q24.1 CYP1A1 cytochrome P450 family 1 subfamily A member 1
Mouse - 524 9 31.34 cM Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
Rat - 524 8q24 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
Previous and Unofficial Names Click here for help
Aryl hydrocarbon hydroxylase | CP11 | AHH | AHRR | Cyp45c | Cypc45c | cytochrome P450 1A1 | microsomal monooxygenase | xenobiotic monooxygenase | cytochrome P450 subfamily I, polypeptide 1 | cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | cytochrome P450
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.1.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
chrysin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.4 pKi 1
pKi 7.4 (Ki 4.2x10-8 M) [1]
5H3'FPE Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.4 pIC50 2
pIC50 7.4 (IC50 4.3x10-8 M) [2]
65PF Small molecule or natural product Hs Inhibition 6.8 pIC50 2
pIC50 6.8 (IC50 1.5x10-7 M) [2]

References

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1. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. (2011) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem, 19 (9): 2842-9. [PMID:21482471]

2. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. (2013) Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem, 56 (10): 4082-92. [PMID:23600958]

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