compound 12 [PMID: 26238322] [Ligand Id: 13151] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3609360 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
| ChEMBL | Displacement of [3H]prazosin from alpha1A adrenoceptor in rat submaxillary gland membrane | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
| GtoPdb | - | - | 9.8 | pKi | - | - | - | Bioorg Med Chem Lett (2015) 25: 3921-3 [PMID:26238322] |
| ChEMBL | Antagonist activity at human alpha1B adrenoceptor assessed as inhibition of norepinephrine-induced increase of intracellular calcium level by cell based assay | F | 6.25 | pIC50 | 560 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
| α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] | ||||||||
| ChEMBL | Displacement of [3H]prazosin from alpha1B adrenoceptor in rat liver membranes | B | 9.21 | pKi | 0.61 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
| α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
| ChEMBL | Binding affinity to human recombinant alpha1D adrenoceptor | B | 7.8 | pKi | 16 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3921-3923 [PMID:26238322] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
