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ChEMBL ligand: CHEMBL14638 (Ciproxifan) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of human AChE | B | 4.06 | pIC50 | 86100 | nM | IC50 | Eur J Med Chem (2019) 180: 690-706 [PMID:31401465] |
ChEMBL | Inhibition of human acetylcholinesterase expressed in HEK 293 cells using acetylthiocholine iodide as substrate by Ellman's method | B | 4.06 | pIC50 | 86100 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells by liquid scintillation counting analysis | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2021) 64: 8246-8262 [PMID:34107215] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells by liquid scintillation counting analysis | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2021) 64: 8246-8262 [PMID:34107215] |
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
ChEMBL | Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2021) 64: 8246-8262 [PMID:34107215] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Displacement of [3H]PSB-11 from human recombinant adenosine A3 receptor expressed in CHO cells by liquid scintillation counting analysis | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2021) 64: 8246-8262 [PMID:34107215] |
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
ChEMBL | Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells | B | 7.37 | pKi | 42.66 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
ChEMBL | Displacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cells | B | 7.2 | pKi | 63.1 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of human BChE | B | 4.11 | pIC50 | 77300 | nM | IC50 | Eur J Med Chem (2019) 180: 690-706 [PMID:31401465] |
ChEMBL | Inhibition of human plasma butyrylcholinesterase by Ellman's method | B | 4.11 | pIC50 | 77300 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
GtoPdb | - | - | 5 | pKi | >10000 | nM | Ki | Pharmacol Rev (2015) 67: 601-55 [PMID:26084539] |
ChEMBL | Displacement of [3H]mepyramine from human histamine H1 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
ChEMBL | Antagonist activity at human recombinant histamine H1 receptor expressed in CHO cells assessed as inhibition of histamine-induced effect by FLIPR assay | B | 5.6 | pKi | >2511.89 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 6897-6901 [PMID:24161834] |
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] | ||||||||
GtoPdb | - | - | 5 | pKi | >10000 | nM | Ki | Pharmacol Rev (2015) 67: 601-55 [PMID:26084539] |
ChEMBL | Displacement of [3H]tiotidine from human histamine H2 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] | ||||||||
ChEMBL | Displacement of [3H] N-alpha methylhistamine from human recombinant histamine H3 receptor expressed in HEK293 cells measured after 90 mins | B | 6.65 | pKi | 224 | nM | Ki | J Med Chem (2021) 64: 8246-8262 [PMID:34107215] |
ChEMBL | Antagonist potency against human H3 receptor in GTPgamma-S-Assay | F | 7.03 | pKi | 94 | nM | Ki | J Med Chem (2005) 48: 306-311 [PMID:15634025] |
ChEMBL | Antagonist potency against human histamine H3 receptor expressed in CHO cells was determined by GTPgamma-S-assay | F | 7.03 | pKi | 94 | nM | Ki | J Med Chem (2004) 47: 2833-2838 [PMID:15139761] |
ChEMBL | Displacement of [3H]NAMH from histamine H3 receptor in human cortex | B | 7.05 | pKi | 89.13 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
ChEMBL | Displacement of [3H]NAMH from human full length histamine H3 receptor expressed in rat C6 cells | B | 7.2 | pKi | 63.1 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
ChEMBL | In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor | B | 7.2 | pKi | 63.1 | nM | Ki | J Med Chem (2005) 48: 38-55 [PMID:15634000] |
ChEMBL | Antagonist activity at human histamine H3 receptor expressed in CHOK1 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay | F | 7.2 | pKi | 63.1 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 6897-6901 [PMID:24161834] |
ChEMBL | In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor | B | 7.2 | pKi | 63 | nM | Ki | J Med Chem (2005) 48: 38-55 [PMID:15634000] |
ChEMBL | Binding affinity to human H3R | B | 7.2 | pKi | 63 | nM | Ki | Eur J Med Chem (2021) 213: 113041-113041 [PMID:33261900] |
ChEMBL | Binding affinity to human H3 receptor | B | 7.2 | pKi | 63 | nM | Ki | J Med Chem (2012) 55: 2406-2415 [PMID:22313227] |
GtoPdb | - | - | 7.3 | pKi | - | - | - |
J Pharmacol Exp Ther (2003) 305: 887-96 [PMID:12606603]; Biochem Pharmacol (2004) 68: 933-45 [PMID:15294456]; Biochem J (2001) 355: 279-88 [PMID:11284713]; Br J Pharmacol (2000) 131: 1247-50 [PMID:11090094]; Eur J Pharmacol (2002) 453: 33-41 [PMID:12393057]; Pharmacol Rev (2015) 67: 601-55 [PMID:26084539] |
ChEMBL | Displacement of [3H]UR-PI294 from human SP-FLAG-tagged H3R expressed in HEK293T cells measured after 60 to 120 mins by liquid scintillation counting analysis | B | 7.31 | pKi | 48.9 | nM | Ki | Eur J Med Chem (2021) 213: 113041-113041 [PMID:33261900] |
ChEMBL | Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 mins | B | 7.34 | pKi | 46 | nM | Ki | Bioorg Med Chem (2011) 19: 2850-2858 [PMID:21498080] |
ChEMBL | Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressing CHO cells | B | 7.34 | pKi | 46 | nM | Ki | J Med Chem (2003) 46: 1523-1530 [PMID:12672253] |
ChEMBL | Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cells | B | 7.34 | pKi | 46 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6682-6685 [PMID:19846299] |
ChEMBL | Inhibition of [125I]iodoproxyfan binding to human histamine H3 receptor of CHO-K1 cells | B | 7.34 | pKi | 46 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 951-954 [PMID:11294398] |
ChEMBL | Displacement of [3H]Nalpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK-293 cells | B | 7.34 | pKi | 46 | nM | Ki | ACS Med Chem Lett (2013) 4: 269-273 [PMID:24900647] |
ChEMBL | Binding affinity to human H3R | B | 7.34 | pKi | 46 | nM | Ki | Eur J Med Chem (2018) 148: 487-497 [PMID:29477889] |
ChEMBL | Inhibition of human histamine H3 receptor | B | 7.34 | pKi | 46 | nM | Ki | Eur J Med Chem (2019) 180: 690-706 [PMID:31401465] |
ChEMBL | Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation counting method | B | 7.34 | pKi | 46 | nM | Ki | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
H3 receptor in Mouse [GtoPdb: 264] [UniProtKB: P58406] | ||||||||
GtoPdb | - | - | 9.4 | pKi | - | - | - | J Neurochem (2004) 90: 1331-8 [PMID:15341517] |
H3 receptor/Histamine H3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4124] [GtoPdb: 264] [UniProtKB: Q9QYN8] | ||||||||
ChEMBL | Inhibition of [125I]iodoproxyfan from rat histamine H3 receptor expressed in CHO-K1 cells | B | 8.41 | pKi | 3.9 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 951-954 [PMID:11294398] |
ChEMBL | Displacement of [3H]NAMH from histamine H3 receptor in rat cortex | B | 9.2 | pKi | 0.63 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
ChEMBL | In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptor | B | 9.29 | pKi | 0.51 | nM | Ki | J Med Chem (2005) 48: 38-55 [PMID:15634000] |
ChEMBL | Displacement of [3H]NAMH from rat full length histamine H3 receptor expressed in rat C6 cells | B | 9.29 | pKi | 0.51 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
ChEMBL | In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptor | B | 9.29 | pKi | 0.51 | nM | Ki | J Med Chem (2005) 48: 38-55 [PMID:15634000] |
GtoPdb | - | - | 9.3 | pKi | - | - | - |
J Pharmacol Exp Ther (2003) 305: 887-96 [PMID:12606603]; Biochem Pharmacol (2004) 68: 933-45 [PMID:15294456]; Biochem Biophys Res Commun (2001) 280: 75-80 [PMID:11162480]; Br J Pharmacol (2000) 131: 1247-50 [PMID:11090094]; Eur J Pharmacol (2002) 453: 33-41 [PMID:12393057] |
ChEMBL | In vitro binding affinity against rat histamine H3 receptor | B | 9.31 | pKi | 0.49 | nM | Ki | J Med Chem (2004) 47: 2678-2687 [PMID:15115409] |
ChEMBL | In vitro inhibitory activity against Histamine H3 receptor for K+ evoked depolarization-induced release of [3H]histamine from synaptosomes of rat cerebral cortex | B | 9.31 | pKi | 0.49 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2379-2382 [PMID:11055360] |
ChEMBL | Histamine H3 receptor antagonist activity in an assay with K+ evoked depolarization-induced release of [3H]-histamine from rat synaptosomes. | F | 9.31 | pKi | 0.49 | nM | Ki | J Med Chem (2000) 43: 3335-3343 [PMID:10966752] |
H4 receptor/Histamine H4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3759] [GtoPdb: 265] [UniProtKB: Q9H3N8] | ||||||||
ChEMBL | Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells | B | 5.73 | pKi | 1862.09 | nM | Ki | J Med Chem (2008) 51: 5423-5430 [PMID:18683917] |
GtoPdb | - | - | 5.73 | pKi | - | - | - |
J Pharmacol Exp Ther (2003) 305: 887-96 [PMID:12606603]; Biochem Pharmacol (2004) 68: 933-45 [PMID:15294456]; Pharmacol Rev (2015) 67: 601-55 [PMID:26084539] |
ChEMBL | Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells | B | 6.21 | pKi | 612 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6682-6685 [PMID:19846299] |
ChEMBL | Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins | B | 6.21 | pKi | 612 | nM | Ki | Bioorg Med Chem (2011) 19: 2850-2858 [PMID:21498080] |
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] | ||||||||
ChEMBL | Inhibition of human MAOA | B | 4.94 | pIC50 | 11400 | nM | IC50 | Eur J Med Chem (2019) 180: 690-706 [PMID:31401465] |
ChEMBL | Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate by Amplex red reagent/horseradish peroxidase coupled fluorescence assay | B | 4.94 | pIC50 | 11400 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
ChEMBL | Inhibition of human MAO-A expressed in baculovirus infected insect cell membranes using kynuramine as substrate up to 30 mins by spectrophotometric method | B | 4.96 | pIC50 | 11000 | nM | IC50 | Eur J Med Chem (2018) 148: 487-497 [PMID:29477889] |
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
ChEMBL | Inhibition of human MAO-B expressed in baculovirus infected insect cell membranes using kynuramine as substrate up to 30 mins by spectrophotometric method | B | 5.68 | pIC50 | 2100 | nM | IC50 | Eur J Med Chem (2018) 148: 487-497 [PMID:29477889] |
ChEMBL | Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using p-tyramine as substrate by Amplex red reagent/horseradish peroxidase coupled fluorescence assay | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
ChEMBL | Inhibition of human MAOB | B | 5.72 | pIC50 | 1900 | nM | IC50 | Eur J Med Chem (2019) 180: 690-706 [PMID:31401465] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]