ChEMBL ligand: CHEMBL379156
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL	Inhibition of human CK2	B	7.7	pIC50	20	nM	IC50	J Med Chem (2006) 49: 3857-3871 [PMID:16789742]
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
ChEMBL	Inhibition of human MKK7beta	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 3857-3871 [PMID:16789742]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of human PI3Kalpha	B	6.03	pIC50	940	nM	IC50	J Med Chem (2006) 49: 3857-3871 [PMID:16789742]
ChEMBL	Inhibition of PI3Kalpha (unknown origin) by lipid kinase assay	B	6.03	pIC50	940	nM	IC50	Medchemcomm (2012) 3: 1337-1355
GtoPdb	-	-	6.03	pIC50	935	nM	IC50	J Med Chem (2006) 49: 3857-71 [PMID:16789742]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL	Inhibition of human PI3Kbeta	B	4.7	pIC50	20000	nM	IC50	J Med Chem (2006) 49: 3857-3871 [PMID:16789742]
ChEMBL	Inhibition of PI3Kbeta (unknown origin) by lipid kinase assay	B	4.7	pIC50	20000	nM	IC50	Medchemcomm (2012) 3: 1337-1355
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL	Inhibition of human PI3Kdelta	B	4.7	pIC50	20000	nM	IC50	J Med Chem (2006) 49: 3857-3871 [PMID:16789742]
ChEMBL	Inhibition of PI3Kdelta (unknown origin) by lipid kinase assay	B	4.7	pIC50	20000	nM	IC50	Medchemcomm (2012) 3: 1337-1355
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb	-	-	7.48	pIC50	33	nM	IC50	J Med Chem (2006) 49: 3857-71 [PMID:16789742]
ChEMBL	Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate	B	7.48	pIC50	33	nM	IC50	Eur J Med Chem (2014) 84: 454-465 [PMID:25050878]
ChEMBL	Inhibition of human PI3Kgamma	B	7.52	pIC50	30	nM	IC50	J Med Chem (2006) 49: 3857-3871 [PMID:16789742]
ChEMBL	Inhibition of recombinant human PI3Kgamma by HTRF assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6586-6590 [PMID:21925880]
ChEMBL	Inhibition of PI3Kgamma (unknown origin) by lipid kinase assay	B	7.52	pIC50	30	nM	IC50	Medchemcomm (2012) 3: 1337-1355

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]