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ChEMBL ligand: CHEMBL379156 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
ChEMBL | Inhibition of human CK2 | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2006) 49: 3857-3871 [PMID:16789742] |
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733] | ||||||||
ChEMBL | Inhibition of human MKK7beta | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2006) 49: 3857-3871 [PMID:16789742] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
ChEMBL | Inhibition of human PI3Kalpha | B | 6.03 | pIC50 | 940 | nM | IC50 | J Med Chem (2006) 49: 3857-3871 [PMID:16789742] |
ChEMBL | Inhibition of PI3Kalpha (unknown origin) by lipid kinase assay | B | 6.03 | pIC50 | 940 | nM | IC50 | Medchemcomm (2012) 3: 1337-1355 |
GtoPdb | - | - | 6.03 | pIC50 | 935 | nM | IC50 | J Med Chem (2006) 49: 3857-71 [PMID:16789742] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
ChEMBL | Inhibition of human PI3Kbeta | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (2006) 49: 3857-3871 [PMID:16789742] |
ChEMBL | Inhibition of PI3Kbeta (unknown origin) by lipid kinase assay | B | 4.7 | pIC50 | 20000 | nM | IC50 | Medchemcomm (2012) 3: 1337-1355 |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
ChEMBL | Inhibition of human PI3Kdelta | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (2006) 49: 3857-3871 [PMID:16789742] |
ChEMBL | Inhibition of PI3Kdelta (unknown origin) by lipid kinase assay | B | 4.7 | pIC50 | 20000 | nM | IC50 | Medchemcomm (2012) 3: 1337-1355 |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2006) 49: 3857-71 [PMID:16789742] |
ChEMBL | Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate | B | 7.48 | pIC50 | 33 | nM | IC50 | Eur J Med Chem (2014) 84: 454-465 [PMID:25050878] |
ChEMBL | Inhibition of human PI3Kgamma | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2006) 49: 3857-3871 [PMID:16789742] |
ChEMBL | Inhibition of recombinant human PI3Kgamma by HTRF assay | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6586-6590 [PMID:21925880] |
ChEMBL | Inhibition of PI3Kgamma (unknown origin) by lipid kinase assay | B | 7.52 | pIC50 | 30 | nM | IC50 | Medchemcomm (2012) 3: 1337-1355 |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]