ChEMBL ligand: CHEMBL1980391 (R-1530, Rg-1530, RG-1530)
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] There should be some charts here, you may need to enable JavaScript!
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948] There should be some charts here, you may need to enable JavaScript!
Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!
ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2 (unknown origin)	B	5.88	pIC50	1330	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 259-263 [PMID:24900658]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL	Inhibition of CDK4 (unknown origin)	B	5	pIC50	>10000	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 259-263 [PMID:24900658]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL	Inhibition of FGFR1 (unknown origin)	B	7.55	pIC50	28	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 259-263 [PMID:24900658]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
GtoPdb	-	-	7.02	pKd	96	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]
ChEMBL	Inhibition of aurora-A (unknown origin)	B	7.24	pIC50	58	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 259-263 [PMID:24900658]
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
ChEMBL	Inhibition of CHK2 (unknown origin)	B	7.62	pIC50	24	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 259-263 [PMID:24900658]
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
GtoPdb	-	-	7.96	pKd	11	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]
ChEMBL	Inhibition of human PLK4	B	7.96	pKi	11	nM	Ki	J. Med. Chem. (2013) 56: 6069-6087 [PMID:23829549]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb	-	-	7.82	pKd	15	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]
ChEMBL	Inhibition of KDR (unknown origin)	B	8	pIC50	10	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 259-263 [PMID:24900658]
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb	-	-	7.59	pKd	26	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
GtoPdb	-	-	7.96	pKd	11	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]
fms related receptor tyrosine kinase 1 in Human [GtoPdb: 1812] [UniProtKB: P17948]
GtoPdb	-	-	8.05	pKd	9	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]
Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
GtoPdb	-	-	7.54	pKd	29	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]
ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
GtoPdb	-	-	7.66	pKd	22	nM	Kd	Cell Cycle (2010) 9: 3364-75 [PMID:20814247]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]