compound 19a [PMID: 30503936] [Ligand Id: 10181] activity data from GtoPdb

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

  • epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
There should be some charts here, you may need to enable JavaScript!
  • Insulin-like growth factor I receptor in Human [GtoPdb: 1801] [UniProtKB: P08069]
There should be some charts here, you may need to enable JavaScript!
  • KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
There should be some charts here, you may need to enable JavaScript!
  • kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
There should be some charts here, you may need to enable JavaScript!
  • MET proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1815] [UniProtKB: P08581]
There should be some charts here, you may need to enable JavaScript!
  • macrophage stimulating 1 receptor in Human [GtoPdb: 1816] [UniProtKB: Q04912]
There should be some charts here, you may need to enable JavaScript!
  • AXL receptor tyrosine kinase in Human [GtoPdb: 1835] [UniProtKB: P30530]
There should be some charts here, you may need to enable JavaScript!
  • SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb - - 6.28 pIC50 520 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]
Insulin-like growth factor I receptor in Human [GtoPdb: 1801] [UniProtKB: P08069]
GtoPdb - - 5.68 pIC50 2100 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb - - 7.19 pIC50 64 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb - - 6.07 pIC50 850 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]
MET proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1815] [UniProtKB: P08581]
GtoPdb - - 7.82 pIC50 15 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]
macrophage stimulating 1 receptor in Human [GtoPdb: 1816] [UniProtKB: Q04912]
GtoPdb - - 8.54 pIC50 2.9 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]
AXL receptor tyrosine kinase in Human [GtoPdb: 1835] [UniProtKB: P30530]
GtoPdb - - 7.28 pIC50 53 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb - - 6.62 pIC50 240 nM IC50 Eur J Med Chem (2019) 163: 10-27 [PMID:30503936]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.