Phosphatidylinositol phosphate kinases | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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Phosphatidylinositol phosphate kinases

Phosphatidylinositol phosphate kinases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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PIP₂ is generated by phosphorylation of PI 4-phosphate or PI 5-phosphate by type I PI 4-phosphate 5-kinases or type II PI 5-phosphate 4-kinases.

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2164

Nomenclature

phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

Common abbreviation

PIP5K1A

Previous and unofficial names

Genes

PIP5K1A (Hs), Pip5k1a (Mm), Pip5k1a (Rn)

Ensembl ID

ENSG00000143398 (Hs), ENSMUSG00000028126 (Mm), ENSRNOG00000021068 (Rn)

UniProtKB AC

Q99755 (Hs), P70182 (Mm)

EC number

2.7.1.68

Inhibitors

ISA-2011B [1]

PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2500

Nomenclature

phosphatidylinositol-4-phosphate 5-kinase type 1 beta

Common abbreviation

PIP5K1B

Previous and unofficial names

Genes

PIP5K1B (Hs), Pip5k1b (Mm), Pip5k1b (Rn)

Ensembl ID

ENSG00000107242 (Hs), ENSMUSG00000024867 (Mm), ENSRNOG00000015232 (Rn)

UniProtKB AC

O14986 (Hs), P70181 (Mm), Q5CZZ9 (Rn)

EC number

2.7.1.68

PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2165

Nomenclature

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

Common abbreviation

PIP5K1C

Previous and unofficial names

PIP5K1-gamma | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | phosphatidylinositol-4-phosphate 5-kinase

Genes

PIP5K1C (Hs), Pip5k1c (Mm), Pip5k1c (Rn)

Ensembl ID

ENSG00000186111 (Hs), ENSMUSG00000034902 (Mm), ENSRNOG00000020577 (Rn)

UniProtKB AC

O60331 (Hs), O70161 (Mm), Q5I6B8 (Rn)

EC number

2.7.1.68

PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2858

Nomenclature

phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Common abbreviation

PIP4K2A

Previous and unofficial names

Genes

PIP4K2A (Hs), Pip4k2a (Mm), Pip4k2a (Rn)

Ensembl ID

ENSG00000150867 (Hs), ENSMUSG00000026737 (Mm), ENSRNOG00000016670 (Rn)

UniProtKB AC

P48426 (Hs), O70172 (Mm), Q9R0I8 (Rn)

EC number

2.7.1.149
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate <=> ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2162

Nomenclature

phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Common abbreviation

PIP4K2B

Previous and unofficial names

Genes

PIP4K2B (Hs), Pip4k2b (Mm), Pip4k2b (Rn)

Ensembl ID

ENSG00000276293 (Hs), ENSMUSG00000018547 (Mm), ENSRNOG00000013030 (Rn)

UniProtKB AC

P78356 (Hs), Q80XI4 (Mm), O88377 (Rn)

EC number

2.7.1.149

PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2163

Nomenclature

phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Common abbreviation

PIP4K2C

Previous and unofficial names

phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | PIP4KII-gamma | PIP5K2C | phosphatidylinositol-5-phosphate 4-kinase, type II, gamma | phosphatidylinositol-5-phosphate 4-kinase

Genes

PIP4K2C (Hs), Pip4k2c (Mm), Pip4k2c (Rn)

Ensembl ID

ENSG00000166908 (Hs), ENSMUSG00000025417 (Mm), ENSRNOG00000005138 (Rn)

UniProtKB AC

Q8TBX8 (Hs), Q91XU3 (Mm), O88370 (Rn)

EC number

2.7.1.149

References

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How to cite this family page

Database page citation:

Phosphatidylinositol phosphate kinases. Accessed on 16/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=782.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.