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phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

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Target not currently curated in GtoImmuPdb

Target id: 2858

Nomenclature: phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Abbreviated Name: PIP4K2A

Family: Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family), Phosphatidylinositol phosphate kinases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 406 10p12.2 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Mouse - 405 2 A3 Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Rat - 406 17q12.3 Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Previous and Unofficial Names Click here for help
PIP5K2A | PIP5KIIA | PIP5KIIalpha | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PIP4KII-alpha | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | phosphatidylinositol-5-phosphate 4-kinase
Database Links Click here for help
Alphafold P48426 (Hs), O70172 (Mm), Q9R0I8 (Rn)
BRENDA 2.7.1.149
CATH/Gene3D 3.30.800.10, 3.30.810.10
ChEMBL Target CHEMBL1795194 (Hs)
Ensembl Gene ENSG00000150867 (Hs), ENSMUSG00000026737 (Mm), ENSRNOG00000016670 (Rn)
Entrez Gene 5305 (Hs), 18718 (Mm), 116723 (Rn)
Human Protein Atlas ENSG00000150867 (Hs)
KEGG Enzyme 2.7.1.149
KEGG Gene hsa:5305 (Hs), mmu:18718 (Mm), rno:116723 (Rn)
OMIM 603140 (Hs)
Pharos P48426 (Hs)
RefSeq Nucleotide NM_005028 (Hs), NM_008845 (Mm), NM_053926 (Rn)
RefSeq Protein NP_005019 (Hs), NP_032871 (Mm), NP_446378 (Rn)
UniProtKB P48426 (Hs), O70172 (Mm), Q9R0I8 (Rn)
Wikipedia PIP4K2A (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of BAY-091 with PIP4K2A
PDB Id:  6YM5
Ligand:  BAY-091
Resolution:  2.5Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.1.149
Description Reaction Reference
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate <=> ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BAY-091 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 8.9 pIC50 1
⤷ pIC50 8.9 (IC50 1.3x10-9 M) [1]
Description: Determined in an ADPGlo kinase activity assay at 10 μM ATP
BAY-297 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 8.9 pIC50 1
⤷ pIC50 8.9 (IC50 1.3x10-9 M) [1]
Description: Determined in an ADPGlo kinase activity assay at 10 μM ATP

References

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1. Wortmann L, Bräuer N, Holton SJ, Irlbacher H, Weiske J, Lechner C, Meier R, Karén J, Siöberg CB, Pütter V et al.. (2021) Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J Med Chem, 64 (21): 15883-15911. [PMID:34699202]

How to cite this page

Phosphatidylinositol phosphate kinases: phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. Last modified on 11/11/2021. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2858.