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phosphatidylinositol-5-phosphate 4-kinase type 2 beta

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Target not currently curated in GtoImmuPdb

Target id: 2162

Nomenclature: phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Abbreviated Name: PIP4K2B

Family: Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family), Phosphatidylinositol phosphate kinases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 416 17q12 PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Mouse - 416 11 61.07 cM Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Rat - 416 10q31 Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Previous and Unofficial Names Click here for help
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta | 1-phosphatidylinositol-5-phosphate 4-kinase B | diphosphoinositide kinase 2-beta | PI5P4Kbeta | PIP4KII-beta | PIP5K2B | PIP5KIIB | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | phosphatidylinositol-5-phosphate 4-kinase
Database Links Click here for help
Alphafold P78356 (Hs), Q80XI4 (Mm), O88377 (Rn)
BRENDA 2.7.1.149
CATH/Gene3D 3.30.800.10, 3.30.810.10
ChEMBL Target CHEMBL5667 (Hs)
Ensembl Gene ENSG00000276293 (Hs), ENSMUSG00000018547 (Mm), ENSRNOG00000013030 (Rn)
Entrez Gene 8396 (Hs), 108083 (Mm), 89812 (Rn)
Human Protein Atlas ENSG00000276293 (Hs)
KEGG Enzyme 2.7.1.149
KEGG Gene hsa:8396 (Hs), mmu:108083 (Mm), rno:89812 (Rn)
OMIM 603261 (Hs)
Pharos P78356 (Hs)
RefSeq Nucleotide NM_003559 (Hs), NM_054051 (Mm), NM_053550 (Rn)
RefSeq Protein NP_003550 (Hs), NP_473392 (Mm), NP_446002 (Rn)
UniProtKB P78356 (Hs), Q80XI4 (Mm), O88377 (Rn)
Wikipedia PIP4K2B (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA
PDB Id:  1BO1
Resolution:  3.0Å
Species:  Human
References:  2
Enzyme Reaction Click here for help
EC Number: 2.7.1.149
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: PIP5K2B
Ligand Sp. Type Action Value Parameter
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.7 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.4 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.1 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 7.0 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.8 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.8 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.6 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 6.6 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.6 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH. (1998) Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell, 94 (6): 829-39. [PMID:9753329]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Phosphatidylinositol phosphate kinases: phosphatidylinositol-5-phosphate 4-kinase type 2 beta. Last modified on 19/08/2015. Accessed on 04/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2162.