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Amino acid hydroxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The amino acid hydroxylases (monooxygenases), EC.1.14.16.-, are iron-containing enzymes which utilise molecular oxygen and sapropterin as co-substrate and co-factor, respectively. In humans, as well as in other mammals, there are two distinct L-Tryptophan hydroxylase 2 genes. In humans, these genes are located on chromosomes 11 and 12 and encode two different homologous enzymes, TPH1 and TPH2.


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Targets of relevance to immunopharmacology are highlighted in blue

L-Phenylalanine hydroxylase C Show summary » More detailed page go icon to follow link

L-Tyrosine hydroxylase C Show summary » More detailed page go icon to follow link

L-Tryptophan hydroxylase 1 C Show summary »

L-Tryptophan hydroxylase 2 C Show summary »

Target Id 1242
Nomenclature L-Tryptophan hydroxylase 2
Previous and unofficial names Tryptophan 5-monooxygenase 2 | neuronal tryptophan hydroxylase | tryptophan 5-hydroxylase 2 | NTPH
Genes TPH2 (Hs), Tph2 (Mm), Tph2 (Rn)
Ensembl ID ENSG00000139287 (Hs), ENSMUSG00000006764 (Mm), ENSRNOG00000003880 (Rn)
UniProtKB AC Q8IWU9 (Hs), Q8CGV2 (Mm), Q8CGU9 (Rn)
EC number
Endogenous activators Protein kinase A-mediated phosphorylation  [7]
Endogenous substrates
rodatristat pIC50 8.1 [4]
TPT-004 pIC50 7.8 [10]
Selective inhibitors
6-fluorotryptophan [9]

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How to cite this family page

Database page citation:

Amino acid hydroxylases. Accessed on 22/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.