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Target not currently curated in GtoImmuPdb
Target id: 1243
Nomenclature: L-Tyrosine hydroxylase
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 528 | 11p15.5 | TH | tyrosine hydroxylase | |
Mouse | - | 498 | 7 88.06 cM | Th | tyrosine hydroxylase | |
Rat | - | 498 | 1q41 | Th | tyrosine hydroxylase |
Previous and Unofficial Names |
Tyrosine 3-monooxygenase | The | tyrosine 3-hydroxylase |
Database Links | |
Alphafold | P07101 (Hs), P24529 (Mm), P04177 (Rn) |
BRENDA | 1.14.16.2 |
CATH/Gene3D | 1.10.800.10 |
ChEMBL Target | CHEMBL1969 (Hs), CHEMBL2462 (Rn) |
DrugBank Target | P07101 (Hs) |
Ensembl Gene | ENSG00000180176 (Hs), ENSMUSG00000000214 (Mm), ENSRNOG00000020410 (Rn) |
Entrez Gene | 7054 (Hs), 21823 (Mm), 25085 (Rn) |
Human Protein Atlas | ENSG00000180176 (Hs) |
KEGG Enzyme | 1.14.16.2 |
KEGG Gene | hsa:7054 (Hs), mmu:21823 (Mm), rno:25085 (Rn) |
OMIM | 191290 (Hs) |
Pharos | P07101 (Hs) |
UniProtKB | P07101 (Hs), P24529 (Mm), P04177 (Rn) |
Wikipedia | TH (Hs) |
Enzyme Reaction | ||||
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Substrates and Reaction Kinetics | ||||||||||||||||||||||||
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Cofactors | ||||||||||||
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Endogenous activators |
Protein kinase A-mediated phosphorylation [1] |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||
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Amino acid hydroxylases: L-Tyrosine hydroxylase . Last modified on 10/07/2018. Accessed on 13/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243.