levodopa

Ligand id: 3639

Name: levodopa

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 103.78
Molecular weight 197.07
XLogP -2.03
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Metabolite or derivative
Approved drug? Yes (FDA (1993), EMA (2003))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
International Nonproprietary Names
INN number INN
2651 levodopa
Synonyms
3,4-dihydroxy-L-phenylalanine | Inbrija® (levodopa inhalation powder) | L-DOPA | Sinemet®
Comments
L-DOPA is the precursor to the neurotransmitters dopamine collectively known as catecholamines. Used in the treatment of Parkisons disease. Note a deuterated derivative D3 L-DOPA with enhanced properties is under development.
Database Links
CAS Registry No. 59-92-7 (source: Scifinder)
ChEBI CHEBI:15765
ChEMBL Ligand CHEMBL1009
DrugBank Ligand DB01235
GtoPdb PubChem SID 178100545
PubChem CID 6047
RCSB PDB Ligand DAH
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Wikipedia L-DOPA

Product suppliers

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Tocris
L-DOPA
Cat. No. 3788