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SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.

Transporters

1227
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Targets of relevance to immunopharmacology are highlighted in blue

OATP1A2 / SLCO1A2 C Show summary »

OATP1B1 / SLCO1B1 C Show summary »

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »

OATP2A1 / SLCO2A1 C Show summary »

OATP2B1 / SLCO2B1 C Show summary »

OATP3A1 / SLCO3A1 C Show summary »

OATP4A1 / SLCO4A1 C Show summary »

OATP4C1 / SLCO4C1 C Show summary »


Target Id 1227
Nomenclature OATP4C1
Systematic nomenclature SLCO4C1
Previous and unofficial names OATPX | SLC21A20 | OATP-H | OATP-M1 | solute carrier family 21 member 20 | organic anion transporter member 4C1 | solute carrier organic anion transporter family member 4C1 | solute carrier organic anion transporter family
Genes SLCO4C1 (Hs), Slco4c1 (Mm), Slco4c1 (Rn)
Ensembl ID ENSG00000173930 (Hs), ENSMUSG00000040693 (Mm), ENSRNOG00000022711 (Rn)
UniProtKB AC Q6ZQN7 (Hs), Q8BGD4 (Mm), Q71MB6 (Rn)
Endogenous substrates
cyclic AMP
steroid conjugates
thyroid hormones
Substrates
anticancer drugs
cardiac glycosides
dipeptidyl peptidase-4 inhibitors
Labelled ligands
[3H]digoxin

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.