Top ▲

SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.


Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

OATP1A2 / SLCO1A2 C Show summary »

OATP1B1 / SLCO1B1 C Show summary »

Target Id 1220
Nomenclature OATP1B1
Systematic nomenclature SLCO1B1
Previous and unofficial names solute carrier organic anion transporter family, member 1B1
Genes SLCO1B1 (Hs)
Ensembl ID ENSG00000134538 (Hs)
UniProtKB AC Q9Y6L6 (Hs)
Bioparadigms SLC Tables SLCO1B1 (Hs)
Endogenous substrates
bile acids
coproporphyrin I [2]
coproporphyrin III [2]
steroid conjugates
thyroid hormones
ACE inhibitors
anticancer drugs
β-lactam antibacterials
bile acid derivatives and conjugates
endothelin receptor antagonists
HIV protease inhibitors
pravastatin (Binding)
cyclosporin A pKi 7.3 [4,8]
rifampicin pKi 6.0 [8]
rifamycin SV pKi 5.7 [11]
estrone-3-sulphate pIC50 7.2 [6]
gemfibrozil [9]
indocyanine green
Labelled ligands
Comment Other inhibitors include, fibrates, flavonoids, glitazones and macrolide antibacterials. Estrone-3-sulphate or the drug substrates atorvastatin, pravastatin and rosuvastatin are used as a probe.

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »

OATP2A1 / SLCO2A1 C Show summary »

OATP2B1 / SLCO2B1 C Show summary »

OATP3A1 / SLCO3A1 C Show summary »

OATP4A1 / SLCO4A1 C Show summary »

OATP4C1 / SLCO4C1 C Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

Click here for help

Show »


Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.