Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	12	550	2q35	SLC11A1	solute carrier family 11 member 1
Mouse	12	548	1 38.54 cM	Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Rat	10	507	9q33	Slc11a1	solute carrier family 11 member 1

Previous and Unofficial Names

LSH | NRAMP | Bcg | Itg | natural resistance associated macrophage protein 1 | Ity | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | solute carrier family 11 (proton-coupled divalent metal ion transporters)

Database Links
Specialist databases
Bioparadigms SLC Tables	SLC11A1 (Hs)
RESOLUTE	SLC11A1 (Hs)
Other databases
Alphafold	P49279 (Hs), P41251 (Mm), P70553 (Rn)
ChEMBL Target	CHEMBL2052040 (Hs)
Ensembl Gene	ENSG00000018280 (Hs), ENSMUSG00000026177 (Mm), ENSRNOG00000014956 (Rn)
Entrez Gene	6556 (Hs), 18173 (Mm), 316519 (Rn)
Human Protein Atlas	ENSG00000018280 (Hs)
KEGG Gene	hsa:6556 (Hs), mmu:18173 (Mm), rno:316519 (Rn)
OMIM	600266 (Hs)
Pharos	P49279 (Hs)
UniProtKB	P49279 (Hs), P41251 (Mm), P70553 (Rn)
Wikipedia	SLC11A1 (Hs)

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference Fe2+ Hs - - Mn2+ Hs - -

Stoichiometry
1 H+ : 1 Fe2+ (out) or 1 Fe2+ (in) : 1 H+ (out)

Immunopharmacology Comments

NRAMP1 / SLC11A1 appears to be involved in macrophage antimicrobial action against intracellular pathogens, and although its precise mechanism is not fully resolved, evidence indicates its involvement in the activation of phagocytes and synthesis of proinflammatory cytokines. Polymorphisms in the human SLC11A1 gene have been associated with susceptibility to several infections [1,3-4], and more recently in genetic susceptibility to development of rheumatoid arthritis [2] (describing a protective role for the SLC11A1D543N variant in the tested population) .

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 6 GO processes GO:0002309 T cell proliferation involved in immune response ISS GO:0006909 phagocytosis ISS GO:0006954 inflammatory response ISS GO:0034341 response to type II interferon ISS GO:0042116 macrophage activation ISS GO:0050766 positive regulation of phagocytosis ISS

Immuno Process:  Antigen presentation GO Annotations:  Associated to 2 GO processes GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS GO:0048002 antigen processing and presentation of peptide antigen ISS

Immuno Process:  T cell (activation) GO Annotations:  Associated to 2 GO processes GO:0002309 T cell proliferation involved in immune response ISS GO:0002827 positive regulation of T-helper 1 type immune response ISS

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0002827 positive regulation of T-helper 1 type immune response ISS

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS GO:0002827 positive regulation of T-helper 1 type immune response ISS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 4 GO processes GO:0001818 negative regulation of cytokine production ISS GO:0001819 positive regulation of cytokine production ISS GO:0032729 positive regulation of type II interferon production ISS GO:0034341 response to type II interferon ISS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes GO:0002309 T cell proliferation involved in immune response ISS GO:0042116 macrophage activation ISS