Top ▲
Target has curated data in GtoImmuPdb
Target id: 966
Nomenclature: NRAMP1
Systematic Nomenclature: SLC11A1
Family: SLC11 family of proton-coupled metal ion transporters
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 12 | 550 | 2q35 | SLC11A1 | solute carrier family 11 member 1 | |
Mouse | 12 | 548 | 1 38.54 cM | Slc11a1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 | |
Rat | 10 | 507 | 9q33 | Slc11a1 | solute carrier family 11 member 1 |
Database Links | |
Specialist databases | |
Bioparadigms SLC Tables | SLC11A1 (Hs) |
RESOLUTE | SLC11A1 (Hs) |
Other databases | |
Alphafold | P49279 (Hs), P41251 (Mm), P70553 (Rn) |
ChEMBL Target | CHEMBL2052040 (Hs) |
Ensembl Gene | ENSG00000018280 (Hs), ENSMUSG00000026177 (Mm), ENSRNOG00000014956 (Rn) |
Entrez Gene | 6556 (Hs), 18173 (Mm), 316519 (Rn) |
Human Protein Atlas | ENSG00000018280 (Hs) |
KEGG Gene | hsa:6556 (Hs), mmu:18173 (Mm), rno:316519 (Rn) |
OMIM | 600266 (Hs) |
Pharos | P49279 (Hs) |
UniProtKB | P49279 (Hs), P41251 (Mm), P70553 (Rn) |
Wikipedia | SLC11A1 (Hs) |
Substrates and Reaction Kinetics | ||||||||||||||||||||||||||||||||||||
|
Stoichiometry | |
1 H+ : 1 Fe2+ (out) or 1 Fe2+ (in) : 1 H+ (out) |
Immunopharmacology Comments |
NRAMP1 / SLC11A1 appears to be involved in macrophage antimicrobial action against intracellular pathogens, and although its precise mechanism is not fully resolved, evidence indicates its involvement in the activation of phagocytes and synthesis of proinflammatory cytokines. Polymorphisms in the human SLC11A1 gene have been associated with susceptibility to several infections [1,3-4], and more recently in genetic susceptibility to development of rheumatoid arthritis [2] (describing a protective role for the SLC11A1D543N variant in the tested population) . |
Immuno Process Associations | ||
|
||
|
||
|
||
|
||
|
||
|
||
|
1. Brochado MJ, Gatti MF, Zago MA, Roselino AM. (2016) Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample. Mem Inst Oswaldo Cruz, 111 (2): 101-5. [PMID:26814595]
2. Niño-Moreno P, Turrubiartes-Martínez E, Oceguera-Maldonado B, Baltazar-Benítez N, Negrete-González C, Oliva-Ramírez B, Baranda L, González-Amaro R. (2017) The Role of NRAMP1/SLC11A1 Gene Variant D543N (1730G/A) in the Genetic Susceptibility to Develop Rheumatoid Arthritis in the Mexican Mestizo population. Rev Invest Clin, 69 (1): 5-10. [PMID:28239176]
3. Somuk BT, Koc S, Ates O, Göktas G, Soyalic H, Uysal IO, Gurbuzler L, Sapmaz E, Sezer S, Eyibilen A. (2016) MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia. Acta Otolaryngol, 136 (11): 1168-1172. [PMID:27223255]
4. Sophie M, Hameed A, Muneer A, Samdani AJ, Saleem S, Azhar A. (2017) SLC11A1 polymorphisms and host susceptibility to cutaneous leishmaniasis in Pakistan. Parasit Vectors, 10 (1): 12. [PMID:28061874]
SLC11 family of proton-coupled metal ion transporters: NRAMP1. Last modified on 19/04/2017. Accessed on 09/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=966.