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Target has curated data in GtoImmuPdb
Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Natural/Endogenous Ligands
- Agonists
- Immunopharmacology Comments
- Immuno Process Associations
- Transduction Mechanisms
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Phenotypes, Alleles and Disease Models
- Biologically Significant Variants
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 342 | 3p21.31 | CXCR6 | C-X-C motif chemokine receptor 6 | 3,7-8 |
| Mouse | 7 | 351 | 9 74.57 cM | Cxcr6 | C-X-C motif chemokine receptor 6 | 9 |
| Rat | 7 | 351 | 8 | Cxcr6 | C-X-C motif chemokine receptor 6 | |
| Previous and Unofficial Names |
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| BONZO [9] | TYMSTR [8] | CD186 | STRL33 [7] | chemokine (C-X-C motif) receptor 6 | |
| Database Links |
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| Specialist databases | |
| GPCRdb | cxcr6_human (Hs), cxcr6_mouse (Mm) |
| Other databases | |
| Alphafold | O00574 (Hs), Q9EQ16 (Mm) |
| ChEMBL Target | CHEMBL5994 (Hs), CHEMBL4630853 (Mm) |
| Ensembl Gene | ENSG00000172215 (Hs), ENSMUSG00000048521 (Mm), ENSRNOG00000006319 (Rn) |
| Entrez Gene | 10663 (Hs), 80901 (Mm), 100124593 (Rn) |
| Human Protein Atlas | ENSG00000172215 (Hs) |
| KEGG Gene | hsa:10663 (Hs), mmu:80901 (Mm), rno:100124593 (Rn) |
| OMIM | 605163 (Hs) |
| Pharos | O00574 (Hs) |
| RefSeq Nucleotide | NM_006564 (Hs), NM_030712 (Mm), NM_001102587 (Rn) |
| RefSeq Protein | NP_006555 (Hs), NP_109637 (Mm), NP_001096057 (Rn) |
| UniProtKB | O00574 (Hs), Q9EQ16 (Mm) |
| Wikipedia | CXCR6 (Hs) |
| Natural/Endogenous Ligands |
| CXCL16 {Sp: Human} , CXCL16 {Sp: Mouse} , CXCL16 {Sp: Rat} |
Download all structure-activity data for this target as a CSV file 
| Agonists | ||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||
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| Agonist Comments | ||||||||||||||||||||||||
| Mouse CXCL16 has also been cloned [11]. CXCL16 is identical to SR-PSOX, an acronym for its ability to function as a scavenger receptor that binds phosphatidylserine and oxidized lipoprotein [2]. | ||||||||||||||||||||||||
| Immunopharmacology Comments |
| CXCR6 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. CXCR6 is upregulated by IL-2 and IL-15 [14]. |
| Immuno Process Associations | ||||||||||||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gi/Go family | |
| Comments: CXCR6 functional assays also include Gi independent adhesion to CXCL16 expressing surfaces [12] and HIV-1 and SIV envelope glycoprotein-mediated cell-cell fusion or HIV-1 and SIV infectivity [3,7] | |
| References: 1,9 | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||
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| Biologically Significant Variants
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References
1. Chandrasekar B, Bysani S, Mummidi S. (2004) CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation. J Biol Chem, 279 (5): 3188-96. [PMID:14625285]
2. Cyster JG. (1999) Chemokines and cell migration in secondary lymphoid organs. Science, 286 (5447): 2098-102. [PMID:10617422]
3. Deng HK, Unutmaz D, KewalRamani VN, Littman DR. (1997) Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature, 388 (6639): 296-300. [PMID:9230441]
4. Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA. (2003) Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. Genes Immun, 4 (4): 245-50. [PMID:12761559]
5. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. (2006) Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells, 24 (4): 1030-41. [PMID:16253981]
6. Kim CH, Kunkel EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, Butcher EC. (2001) Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J Clin Invest, 107 (5): 595-601. [PMID:11238560]
7. Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM. (1997) STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med, 185 (11): 2015-23. [PMID:9166430]
8. Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL et al.. (1997) TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol, 7 (9): 652-60. [PMID:9285716]
9. Matloubian M, David A, Engel S, Ryan JE, Cyster JG. (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol, 1 (4): 298-304. [PMID:11017100]
10. Nakayama T, Hieshima K, Izawa D, Tatsumi Y, Kanamaru A, Yoshie O. (2003) Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. J Immunol, 170 (3): 1136-40. [PMID:12538668]
11. Schweickart VL, Epp A, Raport CJ, Gray PW. (2000) CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J Biol Chem, 75: 9550-9556. [PMID:10734104]
12. Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J et al.. (2004) Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells. J Leukoc Biol, 75 (2): 267-74. [PMID:14634054]
13. Thomas SY, Hou R, Boyson JE, Means TK, Hess C, Olson DP, Strominger JL, Brenner MB, Gumperz JE, Wilson SB et al.. (2003) CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol, 171 (5): 2571-80. [PMID:12928408]
14. Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR. (2000) The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse. J Immunol, 165 (6): 3284-92. [PMID:10975845]
15. Wilbanks A, Zondlo SC, Murphy K, Mak S, Soler D, Langdon P, Andrew DP, Wu L, Briskin M. (2001) Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines. J Immunol, 166 (8): 5145-54. [PMID:11290797]
How to cite this page
Bachelerie F, Ben-Baruch A, Burkhardt AM, Charo IF, Combadiere C, Farber JM, Förster R, Graham GJ, Hills R, Horuk R, Locati M, Luster AD, Mantovani A, Matsushima K, Monaghan AE, Moschovakis GL, Murphy PM, Nibbs RJB, Nomiyama H, Oppenheim JJ, Power CA, Proudfoot AEI, Rosenkilde MM, Rot A, Sozzani S, Sparre-Ulrich AH, Thelen M, Uddin M, Yoshie O, Zlotnik A. Chemokine receptors in GtoPdb v.2025.1. IUPHAR/BPS Guide to Pharmacology CITE. 2025; 2025(1). Available from: https://doi.org/10.2218/gtopdb/F14/2025.1.
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