1. Bardi G, Lipp M, Baggiolini M, Loetscher P. (2001) The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC.
Eur J Immunol, 31 (11): 3291-7.
[PMID:11745346]
2. Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry ML, Magistrelli G, Masternak K, Chevailler A, Delneste Y et al.. (2011) CCR7 is involved in the migration of neutrophils to lymph nodes.
Blood, 117 (4): 1196-204.
[PMID:21051556]
3. Boislève F, Kerdine-Römer S, Rougier-Larzat N, Pallardy M. (2004) Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK.
J Invest Dermatol, 123 (3): 494-502.
[PMID:15304089]
4. Brown MN, Fintushel SR, Lee MH, Jennrich S, Geherin SA, Hay JB, Butcher EC, Debes GF. (2010) Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation.
J Immunol, 185 (8): 4873-82.
[PMID:20833836]
5. Calderón L, Boehm T. (2011) Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus.
Proc Natl Acad Sci USA, 108 (18): 7517-22.
[PMID:21502490]
6. Cheng S, Han L, Guo J, Yang Q, Zhou J, Yang X. (2014) The essential roles of CCR7 in epithelial-to-mesenchymal transition induced by hypoxia in epithelial ovarian carcinomas.
Tumour Biol, 35 (12): 12293-8.
[PMID:25168373]
7. Davalos-Misslitz AC, Rieckenberg J, Willenzon S, Worbs T, Kremmer E, Bernhardt G, Förster R. (2007) Generalized multi-organ autoimmunity in CCR7-deficient mice.
Eur J Immunol, 37 (3): 613-22.
[PMID:17304629]
8. Davalos-Misslitz AC, Worbs T, Willenzon S, Bernhardt G, Förster R. (2007) Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice.
Blood, 110 (13): 4351-9.
[PMID:17785582]
9. Debes GF, Arnold CN, Young AJ, Krautwald S, Lipp M, Hay JB, Butcher EC. (2005) Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.
Nat Immunol, 6 (9): 889-94.
[PMID:16116468]
10. Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A et al.. (2008) Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Cancer Res, 68 (24): 10178-86.
[PMID:19074885]
11. Förster R, Davalos-Misslitz AC, Rot A. (2008) CCR7 and its ligands: balancing immunity and tolerance.
Nat Rev Immunol, 8 (5): 362-71.
[PMID:18379575]
12. Förster R, Schubel A, Breitfeld D, Kremmer E, Renner-Müller I, Wolf E, Lipp M. (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Cell, 99 (1): 23-33.
[PMID:10520991]
13. García-Zepeda EA, Licona-Limón I, Jiménez-Sólomon MF, Soldevila G. (2007) Janus kinase 3-deficient T lymphocytes have an intrinsic defect in CCR7-mediated homing to peripheral lymphoid organs.
Immunology, 122 (2): 247-60.
[PMID:17521370]
14. Gattorno M, Prigione I, Morandi F, Gregorio A, Chiesa S, Ferlito F, Favre A, Uccelli A, Gambini C, Martini A et al.. (2005) Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis.
Arthritis Res Ther, 7 (2): R256-67.
[PMID:15743472]
15. Ghobrial IM, Bone ND, Stenson MJ, Novak A, Hedin KE, Kay NE, Ansell SM. (2004) Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma.
Mayo Clin Proc, 79 (3): 318-25.
[PMID:15008605]
16. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. (2006) Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors.
Stem Cells, 24 (4): 1030-41.
[PMID:16253981]
17. Höpken UE, Achtman AH, Krüger K, Lipp M. (2004) Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens.
J Leukoc Biol, 76 (3): 709-18.
[PMID:15197239]
18. Inngjerdingen M, Damaj B, Maghazachi AA. (2001) Expression and regulation of chemokine receptors in human natural killer cells.
Blood, 97 (2): 367-75.
[PMID:11154210]
19. Ishida K, Iwahashi M, Nakamori M, Nakamura M, Yokoyama S, Iida T, Naka T, Nakamura Y, Yamaue H. (2009) High CCR7 mRNA expression of cancer cells is associated with lymph node involvement in patients with esophageal squamous cell carcinoma.
Int J Oncol, 34 (4): 915-22.
[PMID:19287948]
20. Kim JW, Ferris RL, Whiteside TL. (2005) Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis.
Clin Cancer Res, 11 (21): 7901-10.
[PMID:16278415]
21. Kim SJ, Shin JY, Lee KD, Bae YK, Sung KW, Nam SJ, Chun KH. (2012) MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7.
Breast Cancer Res, 14 (1): R14.
[PMID:22251626]
22. Kohout TA, Nicholas SL, Perry SJ, Reinhart G, Junger S, Struthers RS. (2004) Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.
J Biol Chem, 279: 23214-23222.
[PMID:15054093]
23. Krueger A, Willenzon S, Lyszkiewicz M, Kremmer E, Förster R. (2010) CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus.
Blood, 115 (10): 1906-12.
[PMID:20040757]
24. Krug A, Towarowski A, Britsch S, Rothenfusser S, Hornung V, Bals R, Giese T, Engelmann H, Endres S, Krieg AM et al.. (2001) Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Eur J Immunol, 31 (10): 3026-37.
[PMID:11592079]
25. Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, Arakaki R, Hayashi Y, Kitagawa T, Lipp M et al.. (2006) CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.
Immunity, 24 (2): 165-77.
[PMID:16473829]
26. Liu FY, Safdar J, Li ZN, Fang QG, Zhang X, Xu ZF, Sun CF. (2014) CCR7 regulates cell migration and invasion through MAPKs in metastatic squamous cell carcinoma of head and neck.
Int J Oncol, 45 (6): 2502-10.
[PMID:25270024]
27. Liu JX, Cao X, Tang YC, Liu Y, Tang FR. (2007) CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus.
J Neurochem, 100 (4): 1072-88.
[PMID:17181556]
28. Liu Q, Chen T, Chen G, Shu X, Sun A, Ma P, Lu L, Cao X. (2007) Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-kappaB pathways.
Mol Immunol, 44 (10): 2686-96.
[PMID:17223196]
29. Luchtefeld M, Grothusen C, Gagalick A, Jagavelu K, Schuett H, Tietge UJ, Pabst O, Grote K, Drexler H, Förster R et al.. (2010) Chemokine receptor 7 knockout attenuates atherosclerotic plaque development.
Circulation, 122 (16): 1621-8.
[PMID:20921438]
30. López-Giral S, Quintana NE, Cabrerizo M, Alfonso-Pérez M, Sala-Valdés M, De Soria VG, Fernández-Rañada JM, Fernández-Ruiz E, Muñoz C. (2004) Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination.
J Leukoc Biol, 76 (2): 462-71.
[PMID:15155773]
31. Ma H, Gao L, Li S, Qin J, Chen L, Liu X, Xu P, Wang F, Xiao H, Zhou S et al.. (2015) CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer.
Oncotarget, 6 (27): 24348-60.
[PMID:26176983]
32. Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie HT, Förster R. (2004) Thymic T cell development and progenitor localization depend on CCR7.
J Exp Med, 200 (4): 481-91.
[PMID:15302903]
33. Mo R, Chen J, Han Y, Bueno-Cannizares C, Misek DE, Lescure PA, Hanash S, Yung RL. (2003) T cell chemokine receptor expression in aging.
J Immunol, 170 (2): 895-904.
[PMID:12517955]
34. Mori S, Nakano H, Aritomi K, Wang CR, Gunn MD, Kakiuchi T. (2001) Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses.
J Exp Med, 193 (2): 207-18.
[PMID:11148224]
35. Moschovakis GL, Bubke A, Dittrich-Breiholz O, Braun A, Prinz I, Kremmer E, Förster R. (2012) Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo.
Eur J Immunol, 42 (1): 48-57.
[PMID:21969271]
36. Noor S, Habashy AS, Nance JP, Clark RT, Nemati K, Carson MJ, Wilson EH. (2010) CCR7-dependent immunity during acute Toxoplasma gondii infection.
Infect Immun, 78 (5): 2257-63.
[PMID:20194594]
37. Ohl L, Henning G, Krautwald S, Lipp M, Hardtke S, Bernhardt G, Pabst O, Förster R. (2003) Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs.
J Exp Med, 197 (9): 1199-204.
[PMID:12732661]
38. Ohl L, Mohaupt M, Czeloth N, Hintzen G, Kiafard Z, Zwirner J, Blankenstein T, Henning G, Förster R. (2004) CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Immunity, 21 (2): 279-88.
[PMID:15308107]
39. Okada T, Cyster JG. (2007) CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node.
J Immunol, 178 (5): 2973-8.
[PMID:17312142]
40. Ott TR, Lio FM, Olshefski D, Liu XJ, Ling N, Struthers RS. (2006) The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19.
Biochem Biophys Res Commun, 348 (3): 1089-93.
[PMID:16904643]
41. Qu C, Edwards EW, Tacke F, Angeli V, Llodrá J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N et al.. (2004) Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
J Exp Med, 200 (10): 1231-41.
[PMID:15534368]
42. Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG. (2002) Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.
Nature, 416 (6876): 94-9.
[PMID:11882900]
43. Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL. (2005) The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed.
J Immunol, 174 (7): 4070-80.
[PMID:15778365]
44. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.
Nature, 401 (6754): 708-12.
[PMID:10537110]
45. Sallusto F, Palermo B, Lenig D, Miettinen M, Matikainen S, Julkunen I, Forster R, Burgstahler R, Lipp M, Lanzavecchia A. (1999) Distinct patterns and kinetics of chemokine production regulate dendritic cell function.
Eur J Immunol, 29 (5): 1617-25.
[PMID:10359116]
46. Schneider MA, Meingassner JG, Lipp M, Moore HD, Rot A. (2007) CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells.
J Exp Med, 204 (4): 735-45.
[PMID:17371928]
47. Schweickart VL, Raport CJ, Godiska R, Byers MG, Eddy Jr RL, Shows TB, Gray PW. (1994) Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.
Genomics, 23 (3): 643-50.
[PMID:7851893]
48. Seth S, Oberdörfer L, Hyde R, Hoff K, Thies V, Worbs T, Schmitz S, Förster R. (2011) CCR7 essentially contributes to the homing of plasmacytoid dendritic cells to lymph nodes under steady-state as well as inflammatory conditions.
J Immunol, 186 (6): 3364-72.
[PMID:21296980]
49. Somovilla-Crespo B, Alfonso-Pérez M, Cuesta-Mateos C, Carballo-de Dios C, Beltrán AE, Terrón F, Pérez-Villar JJ, Gamallo-Amat C, Pérez-Chacón G, Fernández-Ruiz E et al.. (2013) Anti-CCR7 therapy exerts a potent anti-tumor activity in a xenograft model of human mantle cell lymphoma.
J Hematol Oncol, 6: 89.
[PMID:24305507]
50. Sordi V, Bianchi G, Buracchi C, Mercalli A, Marchesi F, D'Amico G, Yang CH, Luini W, Vecchi A, Mantovani A et al.. (2006) Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by rapamycin.
Transplantation, 82 (6): 826-34.
[PMID:17006331]
51. Sperveslage J, Frank S, Heneweer C, Egberts J, Schniewind B, Buchholz M, Bergmann F, Giese N, Munding J, Hahn SA et al.. (2012) Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma.
Int J Cancer, 131 (4): E371-81.
[PMID:22020953]
52. Stein JV, Soriano SF, M'rini C, Nombela-Arrieta C, de Buitrago GG, Rodríguez-Frade JM, Mellado M, Girard JP, Martínez-A C. (2003) CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.
Blood, 101 (1): 38-44.
[PMID:12393730]
53. Sullivan SK, McGrath DA, Grigoriadis D, Bacon KB. (1999) Pharmacological and signaling analysis of human chemokine receptor CCR-7 stably expressed in HEK-293 cells: high-affinity binding of recombinant ligands MIP-3beta and SLC stimulates multiple signaling cascades.
Biochem Biophys Res Commun, 263: 685-690.
[PMID:10512740]
54. Sánchez-Sánchez N, Riol-Blanco L, de la Rosa G, Puig-Kröger A, García-Bordas J, Martín D, Longo N, Cuadrado A, Cabañas C, Corbí AL et al.. (2004) Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells.
Blood, 104 (3): 619-25.
[PMID:15059845]
55. Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, Nakano H, Kakiuchi T, Lipp M, Boyd RL, Takahama Y. (2004) CCR7 signals are essential for cortex-medulla migration of developing thymocytes.
J Exp Med, 200 (4): 493-505.
[PMID:15302902]
56. Walker SR, Aboka A, Ogagan PD, Barksdale Jr EM. (2005) Murine neuroblastoma attenuates dendritic cell cysteine cysteine receptor 7 (CCR7) expression.
J Pediatr Surg, 40 (6): 983-7.
[PMID:15991182]
57. Wendland M, Willenzon S, Kocks J, Davalos-Misslitz AC, Hammerschmidt SI, Schumann K, Kremmer E, Sixt M, Hoffmeyer A, Pabst O et al.. (2011) Lymph node T cell homeostasis relies on steady state homing of dendritic cells.
Immunity, 35 (6): 945-57.
[PMID:22195748]
58. Worbs T, Mempel TR, Bölter J, von Andrian UH, Förster R. (2007) CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo.
J Exp Med, 204 (3): 489-95.
[PMID:17325198]
59. Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O. (1997) Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.
J Biol Chem, 272 (21): 13803-9.
[PMID:9153236]
60. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O. (1998) Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7.
J Biol Chem, 273: 7118-7122.
[PMID:9507024]
Target has curated data in GtoImmuPdb
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