S100 calcium binding protein A11 | EF-hand domain containing proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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S100 calcium binding protein A11

  Target has curated data in GtoImmuPdb

Target id: 3083

Nomenclature: S100 calcium binding protein A11

Systematic Nomenclature: S100A11

Family: EF-hand domain containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 105 1q21.3 S100A11 S100 calcium binding protein A11
Mouse - 98 Chr 3, 40.51 cM, cytoband E-F; 3 F2.1 S100a11 S100 calcium binding protein A11
Rat - 98 2q34 S100a11 S100 calcium binding protein A11
Previous and Unofficial Names
calgizzarin [9] | MLN70 | S100-A11
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
S100A11 is a pro-inflammatory calcium-binding protein. Elevated S100A11 has been reported as a marker of disease activity and extramuscular manifestations in inflammatory myopathies [1], and as a diagnostic marker that can distinguish systemic lupus erythematosus patients from healthy controls [4,11].
Cell Type Associations
Immuno Cell Type:  T cells
References:  4
Immuno Cell Type:  Natural killer cells
References:  4
Immuno Cell Type:  B cells
References:  4
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   monocyte (CL:0000576)
Comment:  S100A11 is released by circulating mononuclear cells. The specific cell type(s) has not been fully determined. Elevated levels are detected in patients with SLE (circulating plasma level) [4] and RA (in synovial tissues and fluid) [2].
References:  4
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
General Comments
S100A11 is expressed in a variety of human tissues including skin, placenta, lung, PBMCs, kidney and heart, but it is not expressed in the brain [6]. Expression is elevated in some cancers [8,10], and in chronic inflammatory diseases [2,4]. The protein localises in the nucleus, cytoplasm and cell periphery [3,5,7]. S100A11 contains 2 EF-hand Ca2+-binding motifs.

References

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1. Andrés Cerezo L, Hulejová H, Šumová B, Kropáčková T, Kryštůfková O, Klein M, Mann HF, Zámečník J, Pecha O, Pavelka K et al.. (2019) Pro-inflammatory S100A11 is elevated in inflammatory myopathies and reflects disease activity and extramuscular manifestations in myositis. Cytokine, 116: 13-20. [PMID:30684913]

2. Andrés Cerezo L, Šumová B, Prajzlerová K, Veigl D, Damgaard D, Nielsen CH, Pavelka K, Vencovský J, Šenolt L. (2017) Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis. Arthritis Res. Ther., 19 (1): 79. [PMID:28446208]

3. Broome AM, Eckert RL. (2004) Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. J. Invest. Dermatol., 122 (1): 29-38. [PMID:14962086]

4. Cerezo LA, Šumová B, Hulejová H, Štorkánová H, Szczuková L, Tomčík M, Bečvář R, Pavelka K, Vencovský J, Závada J et al.. (2019) S100A11 (calgizzarin) is released by circulating mononuclear cells and its elevated plasma levels distinguish systemic lupus erythematosus patients from healthy individuals. Clin. Exp. Rheumatol., 37 (2): 338-339. [PMID:30719969]

5. Cross SS, Hamdy FC, Deloulme JC, Rehman I. (2005) Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers. Histopathology, 46 (3): 256-69. [PMID:15720411]

6. Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N, Yamada H, Namba M, Huh NH. (2003) S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. J. Cell Biol., 163 (4): 825-35. [PMID:14623863]

7. Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, Yamada H, Huh NH. (2008) S100A11, an dual mediator for growth regulation of human keratinocytes. Mol. Biol. Cell, 19 (1): 78-85. [PMID:17978094]

8. Tanaka M, Adzuma K, Iwami M, Yoshimoto K, Monden Y, Itakura M. (1995) Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. Cancer Lett., 89 (2): 195-200. [PMID:7889529]

9. Todoroki H, Kobayashi R, Watanabe M, Minami H, Hidaka H. (1991) Purification, characterization, and partial sequence analysis of a newly identified EF-hand type 13-kDa Ca(2+)-binding protein from smooth muscle and non-muscle tissues. J. Biol. Chem., 266 (28): 18668-73. [PMID:1917990]

10. Tomasetto C, Régnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC. (1995) Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. Genomics, 28 (3): 367-76. [PMID:7490069]

11. Šumová B, Cerezo LA, Szczuková L, Nekvindová L, Uher M, Hulejová H, Moravcová R, Grigorian M, Pavelka K, Vencovský J et al.. (2019) Circulating S100 proteins effectively discriminate SLE patients from healthy controls: a cross-sectional study. Rheumatol. Int., 39 (3): 469-478. [PMID:30392117]

How to cite this page

EF-hand domain containing proteins: S100 calcium binding protein A11. Last modified on 01/05/2019. Accessed on 26/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3083.