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Target has curated data in GtoImmuPdb
Target id: 3057
Nomenclature: nuclear factor, erythroid 2 like 2
Abbreviated Name: NRF2
Family: Basic leucine zipper domain TFs
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 605 | 2q31.2 | NFE2L2 | NFE2 like bZIP transcription factor 2 | 2 |
Mouse | - | 597 | 2 44.75 cM | Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | |
Rat | - | 604 | 3q23 | Nfe2l2 | NFE2 like bZIP transcription factor 2 | |
Gene and Protein Information Comments | ||||||
Multiple transcript variants encoding different isoforms have been characterized for the human gene. |
Previous and Unofficial Names |
nuclear factor, erythroid derived 2, like 2 | nuclear factor | NF-E2-related factor 2 | nuclear factor, erythroid 2-like 2 |
Database Links | |
Alphafold | Q16236 (Hs), Q60795 (Mm), O54968 (Rn) |
ChEMBL Target | CHEMBL1075094 (Hs), CHEMBL1075148 (Mm), CHEMBL1075141 (Rn) |
Ensembl Gene | ENSG00000116044 (Hs), ENSMUSG00000015839 (Mm), ENSRNOG00000001548 (Rn) |
Entrez Gene | 4780 (Hs), 18024 (Mm), 83619 (Rn) |
Human Protein Atlas | ENSG00000116044 (Hs) |
KEGG Gene | hsa:4780 (Hs), mmu:18024 (Mm), rno:83619 (Rn) |
OMIM | 600492 (Hs) |
Pharos | Q16236 (Hs) |
RefSeq Nucleotide | NM_006164 (Hs), NM_010902 (Mm), NM_031789 (Rn) |
RefSeq Protein | NP_006155 (Hs), NP_035032 (Mm), NP_113977 (Rn) |
UniProtKB | Q16236 (Hs), Q60795 (Mm), O54968 (Rn) |
Wikipedia | NFE2L2 (Hs) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
NRF2 is included in GToImmuPdb as mutations in this gene have been reported in patients with IMDDHH, an inherited disease in which some of the symptoms arise from defective immune system function [1]. |
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General Comments |
NRF2 is a transcription factor that activates expression of genes containing the antioxidant response element (ARE). ARE-containing genes are involved in the physiological response to cellular insults such as oxidative stress. |
1. Huppke P, Weissbach S, Church JA, Schnur R, Krusen M, Dreha-Kulaczewski S, Kühn-Velten WN, Wolf A, Huppke B, Millan F et al.. (2017) Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder. Nat Commun, 8 (1): 818. [PMID:29018201]
2. Moi P, Chan K, Asunis I, Cao A, Kan YW. (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA, 91 (21): 9926-30. [PMID:7937919]
3. Profeta V, McIntyre K, Wells M, Park C, Lynch DR. (2023) Omaveloxolone: an activator of Nrf2 for the treatment of Friedreich ataxia. Expert Opin Investig Drugs, 32 (1): 5-16. [PMID:36708320]
4. Reisman SA, Gahir SS, Lee CI, Proksch JW, Sakamoto M, Ward KW. (2019) Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates. Drug Des Devel Ther, 13: 1259-1270. [PMID:31118567]
5. Singh A, Venkannagari S, Oh KH, Zhang YQ, Rohde JM, Liu L, Nimmagadda S, Sudini K, Brimacombe KR, Gajghate S et al.. (2016) Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. ACS Chem Biol, 11 (11): 3214-3225. [PMID:27552339]
Basic leucine zipper domain TFs: nuclear factor, erythroid 2 like 2. Last modified on 02/03/2023. Accessed on 04/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3057.