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C-type lectin domain family 4 member A

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2931

Nomenclature: C-type lectin domain family 4 member A

Abbreviated Name: DCIR

Family: C-type lectin-like receptors (CLRs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 237 12p13.31 CLEC4A C-type lectin domain family 4 member A 1
Mouse 1 238 6 58.18 cM Clec4a2 C-type lectin domain family 4, member a2
Rat 1 237 4q42 Clec4a3 C-type lectin domain family 4, member A3
Gene and Protein Information Comments
Variants encoding shorter isoforms of human DCIR are reported. Two splice variants of the mouse gene encode identical shorter protein isoforms, compared to isoform 1 presented here..
Previous and Unofficial Names Click here for help
CD367 | CLECSF6 | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 | Dendritic cell (DC) immunoreceptor (IR) | C-type lectin domain family 4, member A3 | C-type lectin domain family 4, member a2 | C-type lectin domain family 4
Database Links Click here for help
Alphafold Q9UMR7 (Hs), Q9QZ15 (Mm)
CATH/Gene3D 3.10.100.10
Ensembl Gene ENSG00000111729 (Hs), ENSMUSG00000030148 (Mm), ENSRNOG00000010018 (Rn)
Entrez Gene 50856 (Hs), 26888 (Mm), 362431 (Rn)
Human Protein Atlas ENSG00000111729 (Hs)
KEGG Gene hsa:50856 (Hs), mmu:26888 (Mm), rno:362431 (Rn)
OMIM 605306 (Hs)
Pharos Q9UMR7 (Hs)
RefSeq Nucleotide NM_016184 (Hs), NM_001170333 (Mm), NM_001005891 (Rn)
RefSeq Protein NP_057268 (Hs), NP_001163804 (Mm), NP_001005891 (Rn)
UniProtKB Q9UMR7 (Hs), Q9QZ15 (Mm)
Wikipedia CLEC4A (Hs)
Immunopharmacology Comments
CLEC4A is an pattern recognition receptor and immunoreceptor that functions in cell adhesion, cell-cell signalling, glycoprotein turnover, and plays roles in inflammation and the immune response. It contains a immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain.
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Antigen presentation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)

References

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1. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S et al.. (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol, 163 (4): 1973-83. [PMID:10438934]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member A. Last modified on 16/07/2020. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2931.