C-type lectin domain family 4 member A | C-type lectin-like receptors (CLRs) | IUPHAR Guide to IMMUNOPHARMACOLOGY

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C-type lectin domain family 4 member A

  Target has curated data in GtoImmuPdb

Target id: 2931

Nomenclature: C-type lectin domain family 4 member A

Abbreviated Name: DCIR

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 237 12p13.31 CLEC4A C-type lectin domain family 4 member A 1
Mouse 1 262 6 F2; 6 58.18 cM Clec4a2 C-type lectin domain family 4, member a2
Rat 1 237 4q42 Clec4a3 C-type lectin domain family 4, member A3
Gene and Protein Information Comments
Variants encoding shorter isoforms of human DCIR are reported. Two splice variants of the mouse gene encode identical shorter protein isoforms, compared to isoform 1 presented here..
Previous and Unofficial Names
CD367 | CLECSF6 | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 | Dendritic cell (DC) immunoreceptor (IR) | C-type lectin domain family 4, member A3 | C-type lectin domain family 4, member a2 | C-type lectin domain family 4
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
CLEC4A is an pattern recognition receptor and immunoreceptor that functions in cell adhesion, cell-cell signalling, glycoprotein turnover, and plays roles in inflammation and the immune response. It contains a immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain.
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 2 GO processes
GO:0002470 plasmacytoid dendritic cell antigen processing and presentation IDA
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0001818 negative regulation of cytokine production IDA
GO:0032720 negative regulation of tumor necrosis factor production IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0036037 CD8-positive, alpha-beta T cell activation IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0036037 CD8-positive, alpha-beta T cell activation IDA
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA

References

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1. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S et al.. (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J. Immunol., 163 (4): 1973-83. [PMID:10438934]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member A. Last modified on 02/04/2019. Accessed on 17/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2931.