C-type lectin-like receptors (CLRs)

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C-type lectin-like receptors (CLRs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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C-type lectin-like receptors are single-pass type II membrane proteins involved widely in the recognition of pathogens and initiation of the innate response to maintain immune homeostasis [1-2].

Targets

Targets of relevance to immunopharmacology are highlighted in blue

DCIR (C-type lectin domain family 4 member A) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2931
Nomenclature	C-type lectin domain family 4 member A
Common abbreviation	DCIR
Previous and unofficial names	CD367 \| CLECSF6 \| C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 \| Dendritic cell (DC) immunoreceptor (IR) \| C-type lectin domain family 4, member A3 \| C-type lectin domain family 4, member a2 \| C-type lectin domain family 4
Genes	CLEC4A (Hs), Clec4a2 (Mm), Clec4a3 (Rn)
Ensembl ID	ENSG00000111729 (Hs), ENSMUSG00000030148 (Mm), ENSRNOG00000010018 (Rn)
UniProtKB AC	Q9UMR7 (Hs), Q9QZ15 (Mm)

BDCA2 (C-type lectin domain family 4 member C) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3135
Nomenclature	C-type lectin domain family 4 member C
Common abbreviation	BDCA2
Previous and unofficial names	C-type lectin domain family 4, member B2 \| C-type lectin domain family 4 \| C-type lectin domain family 4, member b1 \| BDCA2 \| Blood dendritic cell antigen 2 \| CD303 \| Dendritic lectin \| DLEC \| BDCA-2
Genes	CLEC4C (Hs), Clec4b1 (Mm), Clec4b2 (Rn)
Ensembl ID	ENSG00000198178 (Hs), ENSMUSG00000030147 (Mm), ENSRNOG00000027655 (Rn)
UniProtKB AC	Q8WTT0 (Hs)

DC-SIGN (CD209 molecule) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2930
Nomenclature	CD209 molecule
Common abbreviation	DC-SIGN
Previous and unofficial names	CDSIGN \| CLEC4L
Genes	CD209 (Hs)
Ensembl ID	ENSG00000090659 (Hs)
UniProtKB AC	Q9NNX6 (Hs)

Dectin-1 (C-type lectin domain family 7 member A) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2927
Nomenclature	C-type lectin domain family 7 member A
Common abbreviation	Dectin-1
Previous and unofficial names	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 \| CLECSF12 \| CD369 \| SCARE2 \| Beta-glucan receptor BGR \| Dendritic cell-associated C-type lectin 1 \| C-type lectin domain family 7, member A \| C-type lectin domain family 7, member a \| C-type lectin domain family 7
Genes	CLEC7A (Hs), Clec7a (Mm), Clec7a (Rn)
Ensembl ID	ENSG00000172243 (Hs), ENSMUSG00000079293 (Mm), ENSRNOG00000054251 (Rn)
UniProtKB AC	Q9BXN2 (Hs), Q6QLQ4 (Mm)

Dectin-2 (C-type lectin domain family 6 member A) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2928
Nomenclature	C-type lectin domain family 6 member A
Common abbreviation	Dectin-2
Previous and unofficial names	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 \| CLECSF10 \| CLEC4N \| C-type lectin domain family 4, member n \| C-type lectin domain family 4
Genes	CLEC6A (Hs), Clec4n (Mm)
Ensembl ID	ENSG00000205846 (Hs), ENSMUSG00000023349 (Mm)
UniProtKB AC	Q6EIG7 (Hs), Q9JKF4 (Mm)

Mincle (C-type lectin domain family 4 member E) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2929
Nomenclature	C-type lectin domain family 4 member E
Common abbreviation	Mincle
Previous and unofficial names	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 \| CLECSF9 \| Macrophage-inducible C-type lectin \| C-type lectin domain family 4, member E \| C-type lectin domain family 4, member e \| C-type lectin domain family 4
Genes	CLEC4E (Hs), Clec4e (Mm), Clec4e (Rn)
Ensembl ID	ENSG00000166523 (Hs), ENSMUSG00000030142 (Mm), ENSRNOG00000061394 (Rn)
UniProtKB AC	Q9ULY5 (Hs), Q9R0Q8 (Mm), Q67EQ1 (Rn)

C-type lectin domain family 12 member A / CD371 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3081
Nomenclature	C-type lectin domain family 12 member A
Systematic nomenclature	CD371
Previous and unofficial names	C-type lectin domain family 12, member A \| C-type lectin domain family 12, member a \| C-type lectin domain family 12 \| CLL-1 \| dendritic cell-associated lectin 2 \| DCAL-2 \| myeloid inhibitory C-type lectin-like receptor \| MICL
Genes	CLEC12A (Hs), Clec12a (Mm), Clec12a (Rn)
Ensembl ID	ENSG00000172322 (Hs), ENSMUSG00000053063 (Mm), ENSRNOG00000054860 (Rn)
UniProtKB AC	Q5QGZ9 (Hs), Q504P2 (Mm)

References

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How to cite this family page

Database page citation:

C-type lectin-like receptors (CLRs). Accessed on 28/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=945.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.