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C-type lectin-like receptors (CLRs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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C-type lectin-like receptors are single-pass type II membrane proteins involved widely in the recognition of pathogens and initiation of the innate response to maintain immune homeostasis [1-2].

Targets

Targets of relevance to immunopharmacology are highlighted in blue

DCIR (C-type lectin domain family 4 member A) Show summary » More detailed page

DC-SIGN (CD209 molecule) Show summary » More detailed page

Dectin-1 (C-type lectin domain family 7 member A) Show summary » More detailed page

Dectin-2 (C-type lectin domain family 6 member A) Show summary » More detailed page

Mincle (C-type lectin domain family 4 member E) Show summary » More detailed page

C-type lectin domain family 12 member A / CD371 Show summary » More detailed page

References

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How to cite this family page

Database page citation:

C-type lectin-like receptors (CLRs). Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=945.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.