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Target has curated data in GtoImmuPdb
Target id: 2927
Nomenclature: C-type lectin domain family 7 member A
Abbreviated Name: Dectin-1
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 247 | 12p13.2 | CLEC7A | C-type lectin domain containing 7A | |
Mouse | 1 | 244 | 6 F3 | Clec7a | C-type lectin domain family 7, member a | |
Rat | 1 | 235 | Clec7a | C-type lectin domain containing 7A | ||
Gene and Protein Information Comments | ||||||
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified. |
Database Links | |
Alphafold | Q9BXN2 (Hs), Q6QLQ4 (Mm) |
CATH/Gene3D | 3.10.100.10 |
ChEMBL Target | CHEMBL2034810 (Hs), CHEMBL2034809 (Mm) |
Ensembl Gene | ENSG00000172243 (Hs), ENSMUSG00000079293 (Mm), ENSRNOG00000054251 (Rn) |
Entrez Gene | 64581 (Hs), 56644 (Mm), 502902 (Rn) |
Human Protein Atlas | ENSG00000172243 (Hs) |
KEGG Gene | hsa:64581 (Hs), mmu:56644 (Mm), rno:502902 (Rn) |
OMIM | 606264 (Hs) |
Pharos | Q9BXN2 (Hs) |
RefSeq Nucleotide | NM_197947 (Hs), NM_020008 (Mm), NM_001173386 (Rn) |
RefSeq Protein | NP_922938 (Hs), NP_064392 (Mm), NP_001166857 (Rn) |
UniProtKB | Q9BXN2 (Hs), Q6QLQ4 (Mm) |
Wikipedia | CLEC7A (Hs) |
Agonist Comments | ||
A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2]. |
Immunopharmacology Comments |
Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1]. |
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General Comments |
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). |
1. Brown GD, Gordon S. (2001) Immune recognition. A new receptor for beta-glucans. Nature, 413 (6851): 36-7. [PMID:11544516]
2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg Med Chem, 20 (12): 3898-914. [PMID:22578491]
C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 04/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2927.