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C-type lectin domain family 7 member A

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2927

Nomenclature: C-type lectin domain family 7 member A

Abbreviated Name: Dectin-1

Family: C-type lectin-like receptors (CLRs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 247 12p13.2 CLEC7A C-type lectin domain containing 7A
Mouse 1 244 6 F3 Clec7a C-type lectin domain family 7, member a
Rat 1 235 Clec7a C-type lectin domain containing 7A
Gene and Protein Information Comments
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified.
Previous and Unofficial Names Click here for help
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A | C-type lectin domain family 7, member a | C-type lectin domain family 7
Database Links Click here for help
Alphafold Q9BXN2 (Hs), Q6QLQ4 (Mm)
CATH/Gene3D 3.10.100.10
ChEMBL Target CHEMBL2034810 (Hs), CHEMBL2034809 (Mm)
Ensembl Gene ENSG00000172243 (Hs), ENSMUSG00000079293 (Mm), ENSRNOG00000054251 (Rn)
Entrez Gene 64581 (Hs), 56644 (Mm), 502902 (Rn)
Human Protein Atlas ENSG00000172243 (Hs)
KEGG Gene hsa:64581 (Hs), mmu:56644 (Mm), rno:502902 (Rn)
OMIM 606264 (Hs)
Pharos Q9BXN2 (Hs)
RefSeq Nucleotide NM_197947 (Hs), NM_020008 (Mm), NM_001173386 (Rn)
RefSeq Protein NP_922938 (Hs), NP_064392 (Mm), NP_001166857 (Rn)
UniProtKB Q9BXN2 (Hs), Q6QLQ4 (Mm)
Wikipedia CLEC7A (Hs)
Agonist Comments
A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2].
Immunopharmacology Comments
Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1].
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Comment:  Dectin-1 is widely expressed in macrophage populations.
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Antigen presentation
Immuno Process:  T cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cytokine production & signalling
General Comments
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

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1. Brown GD, Gordon S. (2001) Immune recognition. A new receptor for beta-glucans. Nature, 413 (6851): 36-7. [PMID:11544516]

2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg Med Chem, 20 (12): 3898-914. [PMID:22578491]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 09/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2927.