Top ▲

C-type lectin domain family 7 member A

Click here for help

Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2927

Nomenclature: C-type lectin domain family 7 member A

Abbreviated Name: Dectin-1

Family: C-type lectin-like receptors (CLRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 247 12p13.2 CLEC7A C-type lectin domain containing 7A
Mouse 1 244 6 F3 Clec7a C-type lectin domain family 7, member a
Rat 1 235 Clec7a C-type lectin domain containing 7A
Gene and Protein Information Comments
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified.
Previous and Unofficial Names Click here for help
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A | C-type lectin domain family 7, member a | C-type lectin domain family 7
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2].
Immunopharmacology Comments
Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1].
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Comment:  Dectin-1 is widely expressed in macrophage populations.
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 7 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway ISS
GO:0006910 phagocytosis, recognition IDA
GO:0038187 pattern recognition receptor activity IDA
GO:0050766 positive regulation of phagocytosis IDA
GO:0061760 antifungal innate immune response ISS
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0006910 phagocytosis, recognition IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0042110 T cell activation TAS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway ISS
GO:0002732 positive regulation of dendritic cell cytokine production ISS
GO:0051251 positive regulation of lymphocyte activation IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway ISS
GO:0042110 T cell activation TAS
GO:0051251 positive regulation of lymphocyte activation IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 12 GO processes
GO:0002732 positive regulation of dendritic cell cytokine production ISS
GO:0032729 positive regulation of type II interferon production IDA
GO:0032731 positive regulation of interleukin-1 beta production IDA
GO:0032733 positive regulation of interleukin-10 production IDA
GO:0032735 positive regulation of interleukin-12 production IDA
GO:0032743 positive regulation of interleukin-2 production IDA
GO:0032747 positive regulation of interleukin-23 production ISS
GO:0032755 positive regulation of interleukin-6 production IDA
GO:0032757 positive regulation of interleukin-8 production IMP
GO:0032760 positive regulation of tumor necrosis factor production IDA
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
General Comments
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

Show »

1. Brown GD, Gordon S. (2001) Immune recognition. A new receptor for beta-glucans. Nature, 413 (6851): 36-7. [PMID:11544516]

2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg Med Chem, 20 (12): 3898-914. [PMID:22578491]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 24/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2927.