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C-type lectin domain family 7 member A

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2927

Nomenclature: C-type lectin domain family 7 member A

Abbreviated Name: Dectin-1

Family: C-type lectin-like receptors (CLRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 247 12p13.2 CLEC7A C-type lectin domain containing 7A
Mouse 1 244 6 F3 Clec7a C-type lectin domain family 7, member a
Rat 1 235 Clec7a C-type lectin domain containing 7A
Gene and Protein Information Comments
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified.
Previous and Unofficial Names Click here for help
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A | C-type lectin domain family 7, member a | C-type lectin domain family 7
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Agonist Comments
A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2].
Immunopharmacology Comments
Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1].
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Comment:  Dectin-1 is widely expressed in macrophage populations.
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Antigen presentation
Immuno Process:  T cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cytokine production & signalling
General Comments
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).


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1. Brown GD, Gordon S. (2001) Immune recognition. A new receptor for beta-glucans. Nature, 413 (6851): 36-7. [PMID:11544516]

2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg Med Chem, 20 (12): 3898-914. [PMID:22578491]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 24/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,