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C-type lectin domain family 7 member A

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2927

Nomenclature: C-type lectin domain family 7 member A

Abbreviated Name: Dectin-1

Family: C-type lectin-like receptors (CLRs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 247 12p13.2 CLEC7A C-type lectin domain containing 7A
Mouse 1 244 6 F3 Clec7a C-type lectin domain family 7, member a
Rat 1 235 Clec7a C-type lectin domain containing 7A
Gene and Protein Information Comments
There are six recognised variants of human CLEC7A (a-f), encoding protein isoforms of different lengths. We present variant a/isoform 1 here as the longest transcript and protein. A shorter isoform of the mouse gene with 199 amino acids has been identified.
Previous and Unofficial Names Click here for help
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 | CLECSF12 | CD369 | SCARE2 | Beta-glucan receptor BGR | Dendritic cell-associated C-type lectin 1 | C-type lectin domain family 7, member A | C-type lectin domain family 7, member a | C-type lectin domain family 7
Database Links Click here for help
Alphafold Q9BXN2 (Hs), Q6QLQ4 (Mm)
CATH/Gene3D 3.10.100.10
ChEMBL Target CHEMBL2034810 (Hs), CHEMBL2034809 (Mm)
Ensembl Gene ENSG00000172243 (Hs), ENSMUSG00000079293 (Mm), ENSRNOG00000054251 (Rn)
Entrez Gene 64581 (Hs), 56644 (Mm), 502902 (Rn)
Human Protein Atlas ENSG00000172243 (Hs)
KEGG Gene hsa:64581 (Hs), mmu:56644 (Mm), rno:502902 (Rn)
OMIM 606264 (Hs)
Pharos Q9BXN2 (Hs)
RefSeq Nucleotide NM_197947 (Hs), NM_020008 (Mm), NM_001173386 (Rn)
RefSeq Protein NP_922938 (Hs), NP_064392 (Mm), NP_001166857 (Rn)
UniProtKB Q9BXN2 (Hs), Q6QLQ4 (Mm)
Wikipedia CLEC7A (Hs)
Agonist Comments
A series of Dectin-1 agonist β(1,3) oligosaccharides with aminoalkyl groups are reported in [2].
Immunopharmacology Comments
Dectin-1 is a pattern recognition receptor involved in initiating the innate immune response upon recognition of various β(1,3)-linked and β(1,6)-linked glucans from fungi and plants. It mediates phagocytosis and the production of inflammatory mediators [1].
Cell Type Associations
Immuno Cell Type:  Macrophages & monocytes
Comment:  Dectin-1 is widely expressed in macrophage populations.
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 7 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway ISS
GO:0006910 phagocytosis, recognition IDA
GO:0038187 pattern recognition receptor activity IDA
GO:0050766 positive regulation of phagocytosis IDA
GO:0061760 antifungal innate immune response ISS
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0006910 phagocytosis, recognition IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0042110 T cell activation TAS
GO:2000318 positive regulation of T-helper 17 type immune response ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway ISS
GO:0002732 positive regulation of dendritic cell cytokine production ISS
GO:0051251 positive regulation of lymphocyte activation IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway ISS
GO:0042110 T cell activation TAS
GO:0051251 positive regulation of lymphocyte activation IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 12 GO processes
GO:0002732 positive regulation of dendritic cell cytokine production ISS
GO:0032729 positive regulation of type II interferon production IDA
GO:0032731 positive regulation of interleukin-1 beta production IDA
GO:0032733 positive regulation of interleukin-10 production IDA
GO:0032735 positive regulation of interleukin-12 production IDA
GO:0032743 positive regulation of interleukin-2 production IDA
GO:0032747 positive regulation of interleukin-23 production ISS
GO:0032755 positive regulation of interleukin-6 production IDA
GO:0032757 positive regulation of interleukin-8 production IMP
GO:0032760 positive regulation of tumor necrosis factor production IDA
GO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
General Comments
Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

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1. Brown GD, Gordon S. (2001) Immune recognition. A new receptor for beta-glucans. Nature, 413 (6851): 36-7. [PMID:11544516]

2. Tanaka H, Kawai T, Adachi Y, Hanashima S, Yamaguchi Y, Ohno N, Takahashi T. (2012) Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation. Bioorg Med Chem, 20 (12): 3898-914. [PMID:22578491]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 7 member A. Last modified on 02/03/2017. Accessed on 24/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2927.